Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 498 lmo0558 Listeria monocytogenes EGD-e 984498 16802601 lmo0558 NP_464086.1 hypothetical protein Virulence factor MUTATION: pgl mutant exhibited a 15 to 30 fold defect in growth in vivo [Ref6341:Crimmins et al., 2009]. COG2706G, under G: Carbohydrate transport and metabolism 19398547 499 lmo2821 Listeria monocytogenes EGD-e 984504 16804858 lmo2821 NP_466343.1 similar to internalin, Unknown, putative peptidoglycan bound protein (LPXTG motif) Virulence factor MUTATION: mutant attenuated in virulence after intravenous infection of mice [Ref6342:Sabet et al., 2005]. 16177371 500 lmo2067 Listeria monocytogenes EGD-e 984795 16804106 lmo2067 NP_465591.1 similar to conjugated bile acid hydrolase Virulence factor MUTATION: deletion of bsh decreased resistance to bile, bacterial faecal carriage in guinea pigs and liver colonization in mice [Ref6343:Dussurget et al., 2002]. COG3049M, under M: Cell wall/membrane/envelope biogenesis 12180927 501 gtcA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 984958 16804587 lmo2549 NP_466072.1 wall teichoic acid glycosylation protein GtcA Virulence factor MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG2246S, under S: Function unknown 11254558 502 cheA Listeria monocytogenes EGD-e 985032 16802734 lmo0692 AL591976 NP_464219 two-component sensor histidine kinase CheA Virulence factor MUTATION: mutant reduced invasion of Caco-2 cells compared to wild type [Ref6345:Dons et al., 2004]. COG0643NT, under N: Cell motility; T: Signal transduction mechanisms 15155625 503 cheY Listeria monocytogenes EGD-e 985049 16802733 lmo0691 AL591976 NP_464218 chemotaxis response regulator CheY Virulence factor MUTATION: mutant reduced invasion of Caco-2 cells compared to wild type [Ref6345:Dons et al., 2004]. COG2204T, under T: Signal transduction mechanisms 15155625 504 rnhB from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 985073 16803313 lmo1273 NP_464798.1 similar to ribonuclease H rnh Virulence factor MUTATION: mutant attenuated in mice, multiplication was significantly impaired [Ref6346:Bigot et al., 2009]. COG0164L, under L: Replication, recombination and repair 19246760 505 lmo1269 Listeria monocytogenes EGD-e 985087 16803309 lmo1269 NP_464794.1 similar to type-I signal peptidase Virulence factor MUTATION: lmo1269 (sipX) is attenuated in mice [Ref6347:Bonnemain et al., 2004]. COG0681U, under U: Intracellular trafficking, secretion, and vesicular transport 14982622 506 lmo1271 Listeria monocytogenes EGD-e 985089 16803311 lmo1271 NP_464796.1 similar to signal peptidase I Virulence factor MUTATION: lmo1271 (sipZ) mutant is attenuated in mice [Ref6347:Bonnemain et al., 2004]. COG0681U, under U: Intracellular trafficking, secretion, and vesicular transport 14982622 507 tig Listeria monocytogenes EGD-e 985096 16803307 lmo1267 NP_464792.1 trigger factor Virulence factor MUTATION: mutant showed reduced capacity to persist in spleens and livers of infected mice [Ref6348:Bigot et al., 2006]. COG0544O, under O: Posttranslational modification, protein turnover, chaperones 17021213 508 iap Listeria monocytogenes EGD-e 985140 16802625 lmo0582 AL591975 NP_464110 invasion associated secreted endopeptidase Virulence factor MUTATION: mutant is strongly attenuated in mice, deletion led to abnormal cell division and loss of motility [Ref6349:Pilgrim et al., 2003]. COG0791M, under M: Cell wall/membrane/envelope biogenesis 12761132 509 inlA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 985151 16802477 lmo0433 NP_463962.1 Internalin A Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. COG4886S, under S: Function unknown 7558297 510 aroA Listeria monocytogenes EGD-e 985307 16803640 lmo1600 AL591979 NP_465125 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase Virulence factor MUTATION: attenuated in mice [Ref6351:Loeffler et al., 2006]. COG2876E, under E: Amino acid transport and metabolism 16790768 511 clpB Listeria monocytogenes EGD-e 985416 16804245 lmo2206 AL591982 NP_465730 hypothetical protein Virulence factor MUTATION: mutant displayed 100 fold decrease in virulence in bacteria, also attenuated in mice [Ref6352:Chastanet et al., 2004]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 14762012 512 lmo1745 Listeria monocytogenes EGD-e 985561 16803785 lmo1745 NP_465270.1 similar to two-component response regulator Virulence factor MUTATION: VirR deletion severely decreased virulence in mice and invasion in cell culture [Ref6353:Mandin et al., 2005]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 16102006 513 lmo1695 Listeria monocytogenes EGD-e 985618 16803735 lmo1695 NP_465220.1 similar to putative membrane proteins Virulence factor MUTATION: attenuated in mice [Ref6354:Thedieck et al., 2006]. COG2898S, under S: Function unknown 17042784 514 aroB Listeria monocytogenes EGD-e 985753 16803966 lmo1927 AL591981 NP_465451 3-dehydroquinate synthase Virulence factor MUTATION: attenuated in mice [Ref6351:Loeffler et al., 2006]. COG0337E, under E: Amino acid transport and metabolism 16790768 515 lmo1829 Listeria monocytogenes EGD-e 985887 16803869 lmo1829 NP_465354.1 similar to fibronectin binding proteins Virulence factor MUTATION: FbpA mutant attenuated in mice [Ref6355:Dramsi et al., 2004]. COG1293K, under K: Transcription 15228540 516 lmo1821 Listeria monocytogenes EGD-e 985901 16803861 lmo1821 NP_465346.1 similar to putative phosphoprotein phosphatase Virulence factor MUTATION: mutant attenuated in mice [Ref6356:Archambaud et al., 2005]. COG0631T, under T: Signal transduction mechanisms 15813732 517 inlC Listeria monocytogenes EGD-e 985945 16803826 lmo1786 AL591981 NP_465311 internalin C Virulence factor MUTATION: attenuated virulence in mice [Ref6357:Engelbrecht et al., 1996]. COG4886S, under S: Function unknown 8878044 518 lmo1076 Listeria monocytogenes EGD-e 986264 16803116 lmo1076 NP_464601.1 similar to autolysin (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) Virulence factor MUTATION: aut deletion mutants show reduced invasiveness and virulence in mice and guinea pigs [Ref6358:Cabanes et al., 2004]. COG1705NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 15009888 519 pycA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 986269 16803112 lmo1072 NP_464597.1 highly similar to pyruvate carboxylase Virulence factor MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. COG1038C, under C: Energy production and conversion 20097852 520 dltA Listeria monocytogenes EGD-e 986449 16803014 lmo0974 AL591977 NP_464499 D-alanine--poly(phosphoribitol) ligase subunit 1 Virulence factor MUTATION: mutant displayed impaired adherence to various cell lines in vitro, and impaired virulence in mice [Ref6360:Abachin et al., 2002]. COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 11849532 521 lmo0931 Listeria monocytogenes EGD-e 986568 16802971 lmo0931 NP_464456.1 similar to lipoate protein ligase A Virulence factor MUTATION: mutant strain defective for growth, less virulent in animals by a factor of 300 [Ref6361:O'Riordan et al., 2003]. COG0095H, under H: Coenzyme transport and metabolism 14564012 522 lmo0135 Listeria monocytogenes EGD-e 986748 16802183 lmo0135 NP_463668.1 similar to oligopeptide ABC transport system substrate-binding proteins Virulence factor MUTATION: deletion mutant showed reduced bacterial adherence to host cells, severely attenuated in mice [Ref6362:Xayarath et al., 2009]. COG0747E, under E: Amino acid transport and metabolism 19818015 523 clpE from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 986780 16803037 lmo0997 NP_464522.1 ATP-dependent protease Virulence factor MUTATION: mutant strain was avirulent in mice, eliminated in the liver, affected cell division [Ref6363:Nair et al., 1999]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 9987121 524 sod Listeria monocytogenes EGD-e 986791 16803479 lmo1439 NP_464964.1 superoxide dismutase Virulence factor MUTATION: deletion mutant attenuated in mice [Ref6364:Archambaud et al., 2006]. COG0605P, under P: Inorganic ion transport and metabolism 16905535 525 fri Listeria monocytogenes EGD-e 986847 16802983 lmo0943 AL591977 NP_464468 non-heme iron-binding ferritin Virulence factor MUTATION: mutant was impaired in ability to survive in macrophage cells and was attenuated in mice [Ref6365:Olsen et al., 2005]. COG0783P, under P: Inorganic ion transport and metabolism 15758237 526 inlB from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 986892 16802478 lmo0434 NP_463963.1 Internalin B Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. COG4886S, under S: Function unknown 7558297 527 prfA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987031 16802246 lmo0200 NP_463731.1 listeriolysin positive regulatory protein Virulence factor MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. COG0664T, under T: Signal transduction mechanisms 1729245 528 plcA Listeria monocytogenes EGD-e 987032 16802247 lmo0201 NP_463732.1 phosphatidylinositol-specific phospholipase c Virulence factor MUTATION: mutant had attenuated virulence in mice, failed to grow in host tissues [Ref6367:Camilli et al., 1991]. 1847723 529 hly from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987033 16802248 lmo0202 NP_463733.1 listeriolysin O precursor Virulence factor MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. 11901168 530 mpl from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987034 16802249 lmo0203 NP_463734.1 Zinc metalloproteinase precursor Virulence factor MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. COG3227E, under E: Amino acid transport and metabolism 1311708 531 actA Listeria monocytogenes EGD-e 987035 16802250 lmo0204 AL591974 NP_463735 actin-assembly inducing protein precursor Virulence factor MUTATION: mutant impaired in cell to cell spread, attenuated in maternal organs [Ref6370:Bakardjiev et al., 2005]. 15871123 532 plcB from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987036 16802251 lmo0205 NP_463736.1 phospholipase C Virulence factor MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. 7591052 533 flaA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987167 16802732 lmo0690 NP_464217.1 flagellin Virulence factor MUTATION: mutant strain impaired colonization in plant tissue [Ref6372:Gorski et al., 2009]. COG1344N, under N: Cell motility 19357783 534 clpC from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987203 16802278 lmo0232 NP_463763.1 endopeptidase Clp ATP-binding chain C Virulence factor MUTATION: mutant strain showed a restricted capacity to grow in bone-marrow-derived macrophages, and an attenuated virulence in mice [Ref6373:Rouquette et al., 1996]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 8885268 535 ami Listeria monocytogenes EGD-e 987254 16804596 lmo2558 AL591983 NP_466081 autolysin, amidase Virulence factor MUTATION: mutant strains showed a significant reduction in adherence to several cell types, attenuated in mice [Ref6374:Milohanic et al., 2001]. COG5632M, under M: Cell wall/membrane/envelope biogenesis 11251838 536 inlG Listeria monocytogenes EGD-e 987350 16802308 lmo0262 NP_463793.1 internalin G Virulence factor MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. COG4886S, under S: Function unknown 9862466 537 inlH Listeria monocytogenes EGD-e 987355 16802309 lmo0263 NP_463794.1 internalin H Virulence factor MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. COG4886S, under S: Function unknown 9862466 538 inlE Listeria monocytogenes EGD-e 987358 16802310 lmo0264 NP_463795.1 internalin E Virulence factor MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. COG4886S, under S: Function unknown 9862466 539 clpP from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987364 16804506 lmo2468 NP_465991.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and attenuated virulence in mice [Ref6376:Gaillot et al., 2000]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 10760131 540 lmo0292 Listeria monocytogenes EGD-e 987455 16802338 lmo0292 NP_463823.1 similar to heat-shock protein htrA serine protease Virulence factor MUTATION: attenuated in mice [Ref6377:Wilson et al., 2006]. COG0265O, under O: Posttranslational modification, protein turnover, chaperones 16369036 541 lmo2537 Listeria monocytogenes EGD-e 987487 16804575 lmo2537 NP_466060.1 similar to UDP-N-acetylglucosamine 2-epimerase Virulence factor MUTATION: mutant avirulent in mice [Ref6378:Dubail et al., 2006]. COG0381M, under M: Cell wall/membrane/envelope biogenesis 16952950 542 lmo0317 Listeria monocytogenes EGD-e 987534 16802362 lmo0317 NP_463847.1 similar to phosphomethylpyrimidine kinase (ThiD) Virulence factor MUTATION: knockout inhibited growth in mMWB and reduced spread in epithelial cells [Ref6379:Schauer et al., 2009]. COG0351H, under H: Coenzyme transport and metabolism 19181806 543 relA from Listeria monocytogenes EGD-e Listeria monocytogenes EGD-e 987788 16803563 lmo1523 NP_465048.1 similar to (p)ppGpp synthetase Virulence factor MUTATION: impaired growth, avirulent in a murine model [Ref6380:Taylor et al., 2002]. COG0317TK, under T: Signal transduction mechanisms; K: Transcription 11790730 544 lmo0415 Listeria monocytogenes EGD-e 987823 16802459 lmo0415 NP_463944.1 similar to endo-1,4-beta-xylanase Virulence factor MUTATION: lmo0415 (pgdA) is attenuated in mice [Ref6381:Boneca et al., 2007]. COG0726G, under G: Carbohydrate transport and metabolism 17215377 1419 plcB from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2797078 46906437 LMOf2365_0216 YP_012826.1 phospholipase C Virulence factor MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. 7591052 1420 hly from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2797098 46906434 LMOf2365_0213 YP_012823.1 listeriolysin O Virulence factor MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. 11901168 1421 degU Listeria monocytogenes str. 4b F2365 2797137 46908687 LMOf2365_2488 AE017262 YP_015076 DNA-binding response regulator DegU Virulence factor MUTATION: mutant strain showed reduction in motility, attenuated in mice [Ref6557:Williams et al., 2005]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 16213668 1422 inlF from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2797185 46906647 LMOf2365_0429 YP_013036.1 internalin Virulence factor MUTATION: deletion mutant avirulent in mice [Ref6558:Engelbrecht et al., 1998]. COG4886S, under S: Function unknown 9791184 1423 recQ Listeria monocytogenes str. 4b F2365 2797731 46908944 LMOf2365_2745 YP_015333.1 ATP-dependent DNA helicase RecQ Virulence factor MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG0514L, under L: Replication, recombination and repair 11254558 1424 LMOf2365_0094 Listeria monocytogenes str. 4b F2365 2798471 46906316 LMOf2365_0094 YP_012705.1 pentapeptide repeats domain protein Virulence factor MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. COG1357S, under S: Function unknown 14638794 1425 inlA from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2798475 46906689 LMOf2365_0471 YP_013078.1 internalin A Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. COG4886S, under S: Function unknown 7558297 1426 LMOf2365_1971 Listeria monocytogenes str. 4b F2365 2798554 46908175 LMOf2365_1971 YP_014564.1 ATP-dependent DNA helicase RecQ, putative Virulence factor MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG0514L, under L: Replication, recombination and repair 11254558 1427 gtcA from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2798680 46908721 LMOf2365_2522 YP_015110.1 cell wall teichoic acid glycosylation protein GtcA Virulence factor MUTATION: a gtca mutant showed diminished ability to invade intestinal epithelial cells, was attenuated in mice [Ref6344:Autret et al., 2001]. COG2246S, under S: Function unknown 11254558 1428 agrA Listeria monocytogenes str. 4b F2365 2798696 46906282 LMOf2365_0060 AE017262 YP_012671 accessory gene regulator protein A Virulence factor MUTATION: virulence of a agrA mutant was attenuated in a mouse [Ref6560:Autret et al., 2003]. COG3279KT, under K: Transcription; T: Signal transduction mechanisms 12874326 1429 mpl from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2799022 46906435 LMOf2365_0214 YP_012824.1 zinc metallopeptidase Virulence factor MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. COG3227E, under E: Amino acid transport and metabolism 1311708 1430 ctsR Listeria monocytogenes str. 4b F2365 2799165 46906462 LMOf2365_0241 AE017262 YP_012851 transcriptional regulator CtsR Virulence factor MUTATION: attenuated virulence in spleens of mice [Ref6561:Karatzas et al., 2003]. COG4463K, under K: Transcription 12940983 1431 inlB from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2799227 0 LMOf2365_0472 - pseudo Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. 7558297 1432 prfA from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2799457 46906432 LMOf2365_0211 YP_012821.1 listeriolysin regulatory protein Virulence factor MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. COG0664T, under T: Signal transduction mechanisms 1729245 1433 clpP from Listeria monocytogenes str. 4b F2365 Listeria monocytogenes str. 4b F2365 2799536 46908640 LMOf2365_2441 YP_015029.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 10760131 1434 prsA-2 Listeria monocytogenes str. 4b F2365 2799631 46908453 LMOf2365_2252 YP_014842.1 protein export protein Virulence factor MUTATION: mutant attenuated in mice, impaired cell to cell spread in host cells [Ref6562:Alonzo et al., 2009]. COG0760O, under O: Posttranslational modification, protein turnover, chaperones 19451247 3600 clpP from Listeria monocytogenes HCC23 Listeria monocytogenes HCC23 7078568 217964793 LMHCC_1513 YP_002350471.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 10760131 3601 LMHCC_0048 Listeria monocytogenes HCC23 7078927 217963347 LMHCC_0048 YP_002349025.1 cell wall teichoic acid glycosylation protein GtcA Virulence factor MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG2246S, under S: Function unknown 11254558 3602 LMHCC_0614 Listeria monocytogenes HCC23 7078992 217963906 LMHCC_0614 YP_002349584.1 ATP-dependent DNA helicase, recQ Virulence factor MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG0514L, under L: Replication, recombination and repair 11254558 3603 clpP from Listeria monocytogenes HCC23 Listeria monocytogenes HCC23 7079328 217963429 LMHCC_0131 YP_002349107.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 10760131 3604 srtB from Listeria monocytogenes HCC23 Listeria monocytogenes HCC23 7079719 217963658 LMHCC_0362 YP_002349336.1 sortase, SrtB family Virulence factor MUTATION: mutant showed attenuated virulence in mice [Ref6821:Bierne et al., 2004]. COG4509S, under S: Function unknown 15028680 3605 LMHCC_2768 Listeria monocytogenes HCC23 7080110 217966039 LMHCC_2768 YP_002351717.1 ATP-dependent DNA helicase RecQ Virulence factor MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG0514L, under L: Replication, recombination and repair 11254558 3606 LMHCC_2601 Listeria monocytogenes HCC23 7080876 217965872 LMHCC_2601 YP_002351550.1 pentapeptide repeats domain protein Virulence factor MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. COG1357S, under S: Function unknown 14638794 3607 LMHCC_1438 Listeria monocytogenes HCC23 7081139 217964719 LMHCC_1438 YP_002350397.1 Exo-glucosaminidase LytG (Exo-beta-N-acetylglucosaminidase lytG) (Peptidoglycan hydrolase lytG) (AutolysinlytG) Virulence factor MUTATION: mutant strain severely attenuated in cell culture, impaired for adhesion to certain eukaryotic cells [Ref6822:Wang and Lin, 2008]. COG1705NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 18599819 3809 inlF from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702134 226223039 Lm4b_00433 YP_002757146.1 internalin, peptidoglycan bound protein (LPXTG motif) Virulence factor MUTATION: deletion mutant avirulent in mice [Ref6558:Engelbrecht et al., 1998]. COG4886S, under S: Function unknown 9791184 3810 inlA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702161 226223065 Lm4b_00461 YP_002757172.1 Internalin A Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. COG4886S, under S: Function unknown 7558297 3811 pycA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702259 226223686 Lm4b_01088 YP_002757793.1 pyruvate carboxylase Virulence factor MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. COG1038C, under C: Energy production and conversion 20097852 3812 relA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702376 226224124 Lm4b_01533 YP_002758231.1 (p)ppGpp synthetase Virulence factor MUTATION: impaired growth, avirulent in murine model [Ref6380:Taylor et al., 2002]. COG0317TK, under T: Signal transduction mechanisms; K: Transcription 11790730 3813 gtcA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702426 226225097 Lm4b_02518 YP_002759204.1 cell wall teichoic acid glycosylation protein GtcA Virulence factor MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] COG2246S, under S: Function unknown 11254558 3814 mpl from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702498 226222832 Lm4b_00201 YP_002756939.1 Zinc metalloproteinase precursor Virulence factor MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. COG3227E, under E: Amino acid transport and metabolism 1311708 3815 inlB from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7702512 226223066 Lm4b_00462 YP_002757173.1 Internalin B Virulence factor MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. COG5632M, under M: Cell wall/membrane/envelope biogenesis 7558297 3816 lsp Listeria monocytogenes serotype 4b str. CLIP 80459 7702964 226224447 Lm4b_01860 YP_002758554.1 signal peptidase II Virulence factor MUTATION: mutant strain showed a reduced efficiency of phagosomal escape in eucaryotic cells and an attenuated virulence [Ref6840:Réglier-Poupet et al., 2003]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 12975369 3817 Lm4b_01887 Listeria monocytogenes serotype 4b str. CLIP 80459 7702988 226224474 Lm4b_01887 YP_002758581.1 Hypothetical protein containing ChW-repeats Virulence factor MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. COG3591E, under E: Amino acid transport and metabolism 14638794 3818 clpE from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7703080 226223615 Lm4b_01017 YP_002757722.1 ATP-dependent protease Virulence factor MUTATION: mutant strain was avirulent in mice, eliminated in the liver, affected cell division [Ref6363:Nair et al., 1999]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 9987121 3819 clpC from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7703657 226222861 Lm4b_00252 YP_002756968.1 endopeptidase Clp ATP-binding chain C Virulence factor MUTATION: mutant strain showed a restricted capacity to grow in bone-marrow-derived macrophages, and an attenuated virulence in mice [Ref6373:Rouquette et al., 1996]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 8885268 3820 Lm4b_00320 Listeria monocytogenes serotype 4b str. CLIP 80459 7703714 226222928 Lm4b_00320 YP_002757035.1 heat-shock protein htrA serine protease Virulence factor MUTATION: attenuated in mice [Ref6377:Wilson et al., 2006]. COG0265O, under O: Posttranslational modification, protein turnover, chaperones 16369036 3821 flaA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7703775 226223321 Lm4b_00718 YP_002757428.1 flagellin protein Virulence factor MUTATION: mutant strain impaired colonization in plant tissue [Ref6372:Gorski et al., 2009], reduced adhesion [Ref6841:Tresse et al., 2009]. COG1344N, under N: Cell motility 19357783, 19295651 3822 hly from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7704059 226222831 Lm4b_00200 YP_002756938.1 listeriolysin O precursor Virulence factor MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. 11901168 3823 prfA from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7704073 226222829 Lm4b_00197 YP_002756936.1 listeriolysin positive regulatory protein Virulence factor MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. COG0664T, under T: Signal transduction mechanisms 1729245 3824 clpP from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7704098 226225016 Lm4b_02437 YP_002759123.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 10760131 3825 plcB from Listeria monocytogenes serotype 4b str. CLIP 80459 Listeria monocytogenes serotype 4b str. CLIP 80459 7704359 226222834 Lm4b_00203 YP_002756941.1 phospholipase C Virulence factor MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. 7591052 3826 srtA Listeria monocytogenes serotype 4b str. CLIP 80459 7704527 226223548 Lm4b_00948 YP_002757655.1 Sortase Virulence factor MUTATION: attenuated in mice [Ref6342:Sabet et al., 2005]. COG3764M, under M: Cell wall/membrane/envelope biogenesis 16177371 4186 pycA from Listeria monocytogenes 08-5578 Listeria monocytogenes 08-5578 8748143 284801404 LM5578_1155 YP_003413269.1 pyruvate carboxylase Virulence factor MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. COG1038C, under C: Energy production and conversion 20097852 4187 pycA from Listeria monocytogenes 08-5923 Listeria monocytogenes 08-5923 8757905 284994546 LM5923_1109 YP_003416314.1 pyruvate carboxylase Virulence factor MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. COG1038C, under C: Energy production and conversion 20097852 4189 pLM33_p09 Listeria monocytogenes Lm1 9350422 298740856 pLM33_p09 YP_003727993.1 pLM33 0009 Virulence factor MUTATION: pLM33_p09 (ctpA) mutant is attenuated in in vivo persistence in mice [Ref6903:Francis and Thomas, 1997]. 9049996 4837 agrD' Listeria monocytogenes DG119D 157939819 accessory gene regulator protein D Virulence factor MUTATION: agrD mutant reduced invasion of Caco-2 intestinal epithelial cells, attenuated in mice [Ref7264:Riedel et al., 2009].; 19154329 4838 attM Listeria monocytogenes ATCC43251 2745842 putative transcriptional attenuator leader peptide Virulence factor MUTATION: attM mutant is attenuated in mice [Ref6344:Autret et al., 2001].; 11254558 4839 CelR Virulence factor MUTATION: celR mutant is attenuated in mice [Ref6344:Autret et al., 2001].; 11254558 4840 Dfp Listeria monocytogenes serotype 4b str. CLIP 80459 7704069 226224428 Lm4b_01841 FM242711 YP_002758535 pantothenate metabolism flavoprotein Virulence factor MUTATION: dfp mutant is attenuated in mice [Ref6344:Autret et al., 2001]. COG0452H, under H: Coenzyme transport and metabolism 11254558 4841 hpt Listeria monocytogenes P14 18129341 putative hexose-6-phosphate transporter Virulence factor MUTATION: hfp deletion mutant showed attenuated virulence in mice [Ref7265:Chico-Calero et al., 2002].; 11756655 4842 irpA Listeria monocytogenes EGD 1403357 internalin-related protein A precursor Virulence factor MUTATION: irpA mutant is attenuated in mice [Ref7266:Domann et al., 1997].; 8975898 4843 LpeA (orf 3387.1) Listeria monocytogenes Virulence factor MUTATION: lpeA mutant strain failed to invade epithelial Caco-2 and hepatocyte TiB73 cell lines [Ref7267:Réglier-Poupet et al., 2003b].; 12496198 4844 ORF483 Listeria monocytogenes Virulence factor MUTATION: ORF483 mutant is attenuated in mice [Ref6344:Autret et al., 2001]. 11254558 4845 ORF626 Listeria monocytogenes Virulence factor MUTATION: ORF626 mutant is attenuated in mice [Ref6344:Autret et al., 2001]. 11254558 4846 pbpX Listeria monocytogenes L99 307570078 penicillin-binding protein, putative Virulence factor MUTATION: pbpX mutant is attenuated in mice [Ref6344:Autret et al., 2001]. 11254558 4847 Ptb Listeria monocytogenes serotype 4b str. CLIP 80459 7702587 226223970 Lm4b_01378 FM242711 YP_002758077 phosphotransbutyrylase Virulence factor MUTATION: ptb mutant is attenuated in mice [Ref6344:Autret et al., 2001]. COG0280C, under C: Energy production and conversion 11254558 4849 svpA Listeria monocytogenes L99 307571771 surface virulence-associated protein A Virulence factor MUTATION: svpA mutant strain strongly attenuated in mice, had restricted bacterial growth in organs [Ref7268:Borezée et al., 2001].; 11700342 4850 YtgP Listeria monocytogenes Virulence factor MUTATION: ytgP mutant is attenuated in mice [Ref6344:Autret et al., 2001]. 11254558 4904 mogR Listeria monocytogenes EGD-e 985015 16802716 lmo0674 AL591976 NP_464201 hypothetical protein Virulence factor MUTATION: mogR deletion mutant has a 250-fold decrease in virulence in mice and has reduced capacity for cell-to-cell spread [Ref7334:Gründling et al., 2004]. 15302931