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lsp

Victor ID 3816
Gene Name lsp
Sequence Strain (Species/Organism) Listeria monocytogenes serotype 4b str. CLIP 80459
NCBI Gene ID 7702964
NCBI Protein GI 226224447
Locus Tag Lm4b_01860
Protein Accession YP_002758554.1
Taxonomy ID 634178
Gene Starting Position 1906690
Gene Ending Position 1907154
Gene Strand (Orientation) -
Protein Name signal peptidase II
DNA Sequence 
>gi|226222639:1906690-1907154 Listeria monocytogenes Clip81459, complete genome
ATTATTTAATTCCTTTCGTTTTTCGGTCGTCTACAAAAACATACACGAGCATTAGTACGACACCAACTGA
AAGCGCGGCATCTGCCACATTAAAGATTGGGAAGTAATAATTTCCCCATACTGTTTGTACAAAATCCACT
ACTTCTTGATGCAAGACTCGGTCGATAAAATTACCAATCGCACCACCTAGAATAAACGCTAAACTAATAG
AAAATAGTCGCTTTCCTTTGGCATATTTTTGCATAATATAAATTATAATTCCAATAACAACAACAGTAAT
AAGATAGAAAAACCACATATGTCCTTCCAAAATACTCCAAGCCGCCCCGTCATTACGGTAGCTTGTCCAG
TATAAGAAACCAGGAATAACTTCTATTTTCTGTCCAATTTCCATATTTTGAACAACAATCCATTTAGTTA
ATTGATCTAGCGCAATCACTGCTAGGGTGATTAGATAATAGTACA
Protein Sequence 
>gi|226224447|ref|YP_002758554.1| signal peptidase II [Listeria monocytogenes serotype 4b str. CLIP 80459] MYYYLITLAVIALDQLTKWIVVQNMEIGQKIEVIPGFLYWTSYRNDGAAWSILEGHMWFFYLITVVVIGIIIYIMQKYAKGKRLFSISLAFILGGAIGNFIDRVLHQEVVDFVQTVWGNYYFPIFNVADAALSVGVVLMLVYVFVDDRKTKGIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant strain showed a reduced efficiency of phagosomal escape in eucaryotic cells and an attenuated virulence (Réglier-Poupet et al., 2003).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Réglier-Poupet et al., 2003: Réglier-Poupet H, Frehel C, Dubail I, Beretti JL, Berche P, Charbit A, Raynaud C. Maturation of lipoproteins by type II signal peptidase is required for phagosomal escape of Listeria monocytogenes. The Journal of biological chemistry. 2003; 278(49); 49469-49477. [PubMed: 12975369].