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pycA from Listeria monocytogenes 08-5578

Victor ID 4186
Gene Name pycA from Listeria monocytogenes 08-5578
Sequence Strain (Species/Organism) Listeria monocytogenes 08-5578
NCBI Gene ID 8748143
NCBI Protein GI 284801404
Locus Tag LM5578_1155
Protein Accession YP_003413269.1
Other Database IDs UniProtKB-ID: D2P0Z3_LISM1
UniRef100: UniRef100_D2P0Z3
UniRef90: UniRef90_D2P0Z3
UniRef50: UniRef50_Q9KWU4
UniParc: UPI0000054DCE
EMBL: CP001602
EMBL-CDS: ADB67907.1
RefSeq_NT: NC_013766.1
GenomeReviews: CP001602_GR
KEGG: lmn:LM5578_1155
Taxonomy ID 653938
Gene Starting Position 1135243
Gene Ending Position 1138683
Gene Strand (Orientation) +
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|284800255:1135243-1138683 Listeria monocytogenes 08-5578, complete genome
AATGAATCGAATTAAAAAAGTATTAGTAGCAAACCGCGGAGAAATTGCTATCCGTGTTATGCGTGCGTGT
ACTGAACTCAAAATCAAAACAGTGGCTATTTATTCACAAGAAGATACTGGAAGTTTTCACCGGTATAAAT
CAGATGAAGCTTATCTGGTTGGAGCAGGGAAAAAGCCTATTGATGCGTATCTAGATATCGAAAACATAAT
AGAGATTGCTAAAGAATCTGGTGCAGACGCGATTCATCCGGGATATGGTTTCTTGTCCGAAAACATTGAA
TTTGCTCGTCGTTGTGAGCAAGAAGGCATTATTTTCGTTGGTCCTAAATCAAAACACCTAGATATGTTTG
GTGACAAAATTAAAGCAAAAGAACAAGCCCTATTAGCTGATATTCCAGTAATTCCGGGAAGTAATGGACC
CGTGGCTGGTATTAAAGAAGTAGAAGAATTTGGTGAGAAAAACGGTTATCCATTAATGATTAAAGCTTCC
CTTGGAGGCGGCGGTCGTGGTATGCGTGTCGTAGAATCAAAAGAACATGTCAAAGAAAGCTTTGAACGCG
CATCTTCAGAAGCAAAAGCTGCATTCGGAAATGATGAAGTATATGTAGAAAAATGTGTGATGAATCCAAA
ACATATTGAAGTACAAATTCTTGGTGACACCCATGGCAACATCGTTCATTTATTCGAACGTGATTGTTCA
ATACAACGACGTCATCAAAAAGTAGTAGAAGTAGCTCCGTGTAATGCGATTACTTCTGAACTACGTAACC
GAATCTGTGATGCTGCAGTAAAACTAATGAAAAATGTTGATTATATTAATGCTGGAACGGTTGAATTTTT
AGTTGAAGGTGACGATTTCTACTTTATCGAAGTAAATCCTCGTGTCCAAGTGGAGCATACAATTACAGAA
ATGATTACTGGTATTGATATCGTTCAATCACAATTATTCATTGCAGATGGTTATGCACTTCACGACCAAC
TAGTAGCTATTCCTAAGCAAGAGGATATCCATATTCACGGTTCTGCTATTCAAAGCCGTATTACAACGGA
AGATCCACTTAATAACTTTATGCCAGATACTGGTCGAGTAGATACGTATCGTTCCACAGGTGGTTTTGGT
GTTCGGTTGGATGCTGGTAACGGCTTCCAAGGAACAGTAGTAACACCATTTTATGATTCATTACTAGTAA
AATTATGTACTTGGGGAATGACATTTGAGCAAGCAACGCGCAAAATGCGTCGTAACCTGATCGAATTCCG
TATCCGCGGTGTCAAAACGAACATTCCTTTCTTATTGAATGTAGTTCGTCATCCAGATTTTGCGAGTGGT
AATTACAATACAAGCTTTATCGATACAACTCCGGAACTATTTAAATTTCCACATATTCGCGACCGTGGTA
CGAAAACGTTGCGTTATATTGGTAATGTAACTGTTAATGGTTTCCCAGGAATTAAGCACCGTGATAAACC
TGTTTATGCAGAACCACGTTTGCCAAAAATTCCTTATGGTTCGCAAATCTCTCCAGGAACAAAACAAATT
TTGGATGCAAAAGGTCCAGAAGGCGTTGTCGACTGGGTGAAAAAACAAGAAGAAGTACTTTTGACAGATA
CTACGCTTCGAGATGCACATCAATCTCTACTTGCGACACGTGTTCGTTCAAAAGATATTTTTCAAGTGGC
AGACGCAATGGCACATTTATTACCAAATATGTTCTCATTTGAAATGTGGGGAGGGGCGACTTTTGACGTG
GCATATCGTTTCCTAAATGAAGATCCATGGGTGCGCCTAGAAACACTTAGAAAACAAATTCCAAATGTGA
TGTTCCAAATGTTACTTCGCGGAGCTAATGCAGTTGGGTATAAAAACTACCCTGACAATGTTATCCGTGA
ATTCGTTAAGCAATCAGCACAATCCGGTGTCGATGTATTCCGCGTGTTTGACAGCTTAAACTGGATCAAA
GGCATGGAAGTGTCCATTGATGCTGTTCGTGAAGCAGGGAAGGTCGTAGAGGCTGCTATCTGCTATACAG
GAGATATCGATGATGACACAAGAACGAAATATACGATTGATTACTATAAAGATATGGCGAAAGAGCTCGT
TGCTCAAGGTACGCATATTTTAGGCATTAAAGATATGGCTGGACTTTTAAAACCACAAGCAGCTTACCGT
TTAATTGGTGAATTAAAAGATACAGTGGATGTTCCAATCCACCTTCATACACATGACACAAGCGGCAACG
GTATTTATACTTACGCAGCAGCAGTCAGTGCAGGAGTTGACATTGTGGATGTTGCATCAAGCGCGATGAG
TGGGGCTACAAGCCAACCAAGTATGACTGGTCTTTACTACGGATTAGTGAATGGTAACCGTCAAACGAAC
TTAGACGCTCAAAATTCCCAAATCATTAATCATTACTGGGAAGATGTCCGTCACTATTATAAAGACTTTG
ACAATGCGCTTAATTCACCTCAAACAGAAGTATACATTCATGAAATGCCAGGTGGTCAATATACTAACCT
TCAACAACAAGCCATTGCAGTTGGACTTGGCGATCGTTGGGACGAAGTGAAAGAAATGTATACAGTGGTT
AATCAAATGTTTGGTGATATCGTTAAAGTAACACCTTCTTCCAAAGTTGTTGGAGACTTGGCGCTATTCA
TGGTTCAAAATGAATTATCCGAAGAAGATGTATATGAAAAAGGCGATACCATTGATTTCCCAGATTCCGT
TATCGAATTCTTTATGGGGGAAATTGGTCAACCATACGGCGGCTTCCCAGAAAAACTTCAAAAACTAGTA
CTCAAAGGACGTACACCACTTACAGATCGTCCAGGCGCTTTAATGGAGCCAGTTAACTTTGTTGATGTCA
AAGCAGAATTAAAAGAAAAAATGGGTTATGAACCAACTGAAAAAGATGTCATTTCCTATATTTTATATCC
AAAAGTGTTCCTAGATTATCAAGATATGATTAACAAATATGGTGATGTAACAGTCCTTGATACACCGACA
TTCTATAAAGGAATGCGTTTAGGGGAAACAATCGAAGTAGAACTTGAAAAAGGAAAAATCCTTTTAATCA
AGCTAAATTCCATTGGTGAACCAATTGCGGATGGCACACGTGTTATCTATTTTGAATTAAATGGACAACC
ACGTGAGATTAACATCCAAGATATGAACGTTCAATCCACTGTTATTGCACGCCGTAAGATTGATACAACT
AACCCTGAACATGTTGGAGCGACAATGACAGGTTCAGTCATTCAAGTTGTTGTGAAAAAAGGCGACTCTG
TGAAAAAAGGAGATCCACTACTAATCACAGAAGCAATGAAAATGGAAACAACGATTCAAGCGCCTTTCGA
TGGAGAAGTTAGCAGCATTTATGTTTCTGACGGCGATACTATCGAATCTGGTGATCTATTAATTGAAGTA
AACAGAATTTA
Protein Sequence 
>gi|284801404|ref|YP_003413269.1| pyruvate carboxylase [Listeria monocytogenes 08-5578] MNRIKKVLVANRGEIAIRVMRACTELKIKTVAIYSQEDTGSFHRYKSDEAYLVGAGKKPIDAYLDIENIIEIAKESGADAIHPGYGFLSENIEFARRCEQEGIIFVGPKSKHLDMFGDKIKAKEQALLADIPVIPGSNGPVAGIKEVEEFGEKNGYPLMIKASLGGGGRGMRVVESKEHVKESFERASSEAKAAFGNDEVYVEKCVMNPKHIEVQILGDTHGNIVHLFERDCSIQRRHQKVVEVAPCNAITSELRNRICDAAVKLMKNVDYINAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITGIDIVQSQLFIADGYALHDQLVAIPKQEDIHIHGSAIQSRITTEDPLNNFMPDTGRVDTYRSTGGFGVRLDAGNGFQGTVVTPFYDSLLVKLCTWGMTFEQATRKMRRNLIEFRIRGVKTNIPFLLNVVRHPDFASGNYNTSFIDTTPELFKFPHIRDRGTKTLRYIGNVTVNGFPGIKHRDKPVYAEPRLPKIPYGSQISPGTKQILDAKGPEGVVDWVKKQEEVLLTDTTLRDAHQSLLATRVRSKDIFQVADAMAHLLPNMFSFEMWGGATFDVAYRFLNEDPWVRLETLRKQIPNVMFQMLLRGANAVGYKNYPDNVIREFVKQSAQSGVDVFRVFDSLNWIKGMEVSIDAVREAGKVVEAAICYTGDIDDDTRTKYTIDYYKDMAKELVAQGTHILGIKDMAGLLKPQAAYRLIGELKDTVDVPIHLHTHDTSGNGIYTYAAAVSAGVDIVDVASSAMSGATSQPSMTGLYYGLVNGNRQTNLDAQNSQIINHYWEDVRHYYKDFDNALNSPQTEVYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIVKVTPSSKVVGDLALFMVQNELSEEDVYEKGDTIDFPDSVIEFFMGEIGQPYGGFPEKLQKLVLKGRTPLTDRPGALMEPVNFVDVKAELKEKMGYEPTEKDVISYILYPKVFLDYQDMINKYGDVTVLDTPTFYKGMRLGETIEVELEKGKILLIKLNSIGEPIADGTRVIYFELNGQPREINIQDMNVQSTVIARRKIDTTNPEHVGATMTGSVIQVVVKKGDSVKKGDPLLITEAMKMETTIQAPFDGEVSSIYVSDGDTIESGDLLIEVNRI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice (Schär et al., 2010).
COG COG1038C, under C: Energy production and conversion
References
Schär et al., 2010: Schär J, Stoll R, Schauer K, Loeffler DI, Eylert E, Joseph B, Eisenreich W, Fuchs TM, Goebel W. Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes. Journal of bacteriology. 2010; 192(7); 1774-1784. [PubMed: 20097852].