Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

hly from Listeria monocytogenes str. 4b F2365

Victor ID 1420
Gene Name hly from Listeria monocytogenes str. 4b F2365
Sequence Strain (Species/Organism) Listeria monocytogenes str. 4b F2365
NCBI Gene ID 2797098
NCBI Protein GI 46906434
Locus Tag LMOf2365_0213
Protein Accession YP_012823.1
Other Database IDs UniProtKB-ID: TACY_LISMF
UniRef100: UniRef100_Q724L1
UniRef90: UniRef90_D2NZ73
UniRef50: UniRef50_Q724L1
UniParc: UPI000016F8D1
EMBL: U25443
EMBL: AE017262
EMBL-CDS: AAA69525.1
EMBL-CDS: AAT03000.1
RefSeq_NT: NC_002973.6
GenomeReviews: AE017262_GR
KEGG: lmf:LMOf2365_0213
TIGR: LMOf2365_0213
eggNOG: NOG04845
HOGENOM: HBG337470
OMA: GAYVAQF
ProtClustDB: CLSK877006
BioCyc: LMON265669:LMOF2365_0213-MONOMER
Taxonomy ID 265669
Gene Starting Position 211178
Gene Ending Position 212767
Gene Strand (Orientation) +
Protein Name listeriolysin O
DNA Sequence 
>gi|85700163:211178-212767 Listeria monocytogenes str. 4b F2365, complete genome
CATGAAAAAAATAATGCTAGTTTTTATTACACTTATATTAGTTAGTCTACCAATTGCGCAACAAACTGAA
GCAAAGGATGCATCTGCATTCAATAAAGAAAATTTAATTTCATCCATAGCACCACCAGCATCTCCGCCTG
CAAGTCCTAAGACGCCAATCGAAAAGAAACACGCGGATGAAATCGATAAGTATATACAAGGATTGGATTA
CAATAAAAACAATGTATTAGTATACCACGGAGATGCAGTGACAAATGTGCCGCCAAGAAAAGGTTATAAA
GATGGAAATGAATATATCGTTGTGGAGAAAAAGAAGAAATCCATCAATCAAAATAATGCAGATATCCAAG
TTGTGAATGCAATTTCGAGCCTAACATATCCAGGTGCTCTCGTGAAAGCGAATTCGGAATTAGTAGAAAA
TCAACCCGATGTTCTTCCTGTCAAACGTGATTCATTAACACTTAGCATTGATTTGCCAGGAATGACTAAT
CAAGACAATAAAATTGTTGTAAAAAATGCTACTAAATCGAACGTTAACAACGCAGTAAATACATTAGTGG
AAAGATGGAATGAAAAATATGCTCAAGCTTATCCAAATGTAAGTGCAAAAATTGATTATGATGACGAAAT
GGCTTACAGTGAATCACAATTAATTGCAAAATTTGGTACGGCATTTAAAGCTGTAAATAATAGCTTGAAT
GTAAACTTCGGCGCAATCAGTGAAGGGAAAATGCAAGAAGAAGTCATTAGTTTTAAACAAATTTACTATA
ACGTGAATGTTAATGAACCTACAAGACCTTCCAGATTTTTCGGCAAAGCTGTTACTAAAGAGCAGTTGCA
AGCGCTTGGAGTGAATGCAGAAAATCCTCCTGCATATATCTCAAGTGTGGCATATGGCCGTCAAGTTTAT
TTGAAATTATCAACTAATTCCCATAGTACCAAAGTAAAAGCTGCTTTTGACGCTGCCGTAAGTGGGAAAT
CTGTCTCAGGTGATGTAGAACTGACAAATATCATCAAAAATTCTTCCTTCAAAGCCGTAATTTACGGTGG
CTCCGCAAAAGATGAAGTTCAAATCATCGACGGTAACCTCGGAGACTTACGAGATATTTTGAAAAAAGGT
GCTACTTTTAACCGGGAAACACCAGGAGTTCCCATTGCCTATACAACAAACTTCTTAAAAGACAATGAAT
TAGCTGTTATTAAAAACAACTCAGAATATATTGAAACAACTTCAAAAGCTTATACAGATGGAAAAATCAA
CATCGATCACTCTGGAGGATACGTTGCTCAATTCAACATCTCTTGGGATGAAATAAATTATGATCCTGAA
GGTAACGAAATTGTTCAACATAAAAACTGGAGCGAAAACAATAAAAGTAAGCTAGCTCATTTCACATCGT
CCATCTATTTGCCAGGTAACGCAAGAAATATTAATGTTTACGCTAAAGAATGCACTGGTTTAGCTTGGGA
ATGGTGGAGAACGGTAATTGATGACCGGAACCTACCGCTTGTGAAAAATAGAAATATCTCCATCTGGGGC
ACTACACTTTATCCGAAATATAGTAATAGTGTAGATAATCCAATCGAATA
Protein Sequence 
>gi|46906434|ref|YP_012823.1| listeriolysin O [Listeria monocytogenes serotype 4b str. F2365] MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENLISSIAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell (Glomski et al., 2002).
References
Glomski et al., 2002: Glomski IJ, Gedde MM, Tsang AW, Swanson JA, Portnoy DA. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. The Journal of cell biology. 2002; 156(6); 1029-1038. [PubMed: 11901168].