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pycA from Listeria monocytogenes 08-5923

Victor ID 4187
Gene Name pycA from Listeria monocytogenes 08-5923
Sequence Strain (Species/Organism) Listeria monocytogenes 08-5923
NCBI Gene ID 8757905
NCBI Protein GI 284994546
Locus Tag LM5923_1109
Protein Accession YP_003416314.1
Other Database IDs UniProtKB-ID: D2P3S9_LISM2
UniRef100: UniRef100_D2P0Z3
UniRef90: UniRef90_D2P0Z3
UniRef50: UniRef50_Q9KWU4
UniParc: UPI0000054DCE
EMBL: CP001604
EMBL-CDS: ADB70952.1
RefSeq_NT: NC_013768.1
GenomeReviews: CP001604_GR
KEGG: lmy:LM5923_1109
Taxonomy ID 637381
Gene Starting Position 1101947
Gene Ending Position 1105387
Gene Strand (Orientation) +
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|284993440:1101947-1105387 Listeria monocytogenes 08-5923, complete genome
AATGAATCGAATTAAAAAAGTATTAGTAGCAAACCGCGGAGAAATTGCTATCCGTGTTATGCGTGCGTGT
ACTGAACTCAAAATCAAAACAGTGGCTATTTATTCACAAGAAGATACTGGAAGTTTTCACCGGTATAAAT
CAGATGAAGCTTATCTGGTTGGAGCAGGGAAAAAGCCTATTGATGCGTATCTAGATATCGAAAACATAAT
AGAGATTGCTAAAGAATCTGGTGCAGACGCGATTCATCCGGGATATGGTTTCTTGTCCGAAAACATTGAA
TTTGCTCGTCGTTGTGAGCAAGAAGGCATTATTTTCGTTGGTCCTAAATCAAAACACCTAGATATGTTTG
GTGACAAAATTAAAGCAAAAGAACAAGCCCTATTAGCTGATATTCCAGTAATTCCGGGAAGTAATGGACC
CGTGGCTGGTATTAAAGAAGTAGAAGAATTTGGTGAGAAAAACGGTTATCCATTAATGATTAAAGCTTCC
CTTGGAGGCGGCGGTCGTGGTATGCGTGTCGTAGAATCAAAAGAACATGTCAAAGAAAGCTTTGAACGCG
CATCTTCAGAAGCAAAAGCTGCATTCGGAAATGATGAAGTATATGTAGAAAAATGTGTGATGAATCCAAA
ACATATTGAAGTACAAATTCTTGGTGACACCCATGGCAACATCGTTCATTTATTCGAACGTGATTGTTCA
ATACAACGACGTCATCAAAAAGTAGTAGAAGTAGCTCCGTGTAATGCGATTACTTCTGAACTACGTAACC
GAATCTGTGATGCTGCAGTAAAACTAATGAAAAATGTTGATTATATTAATGCTGGAACGGTTGAATTTTT
AGTTGAAGGTGACGATTTCTACTTTATCGAAGTAAATCCTCGTGTCCAAGTGGAGCATACAATTACAGAA
ATGATTACTGGTATTGATATCGTTCAATCACAATTATTCATTGCAGATGGTTATGCACTTCACGACCAAC
TAGTAGCTATTCCTAAGCAAGAGGATATCCATATTCACGGTTCTGCTATTCAAAGCCGTATTACAACGGA
AGATCCACTTAATAACTTTATGCCAGATACTGGTCGAGTAGATACGTATCGTTCCACAGGTGGTTTTGGT
GTTCGGTTGGATGCTGGTAACGGCTTCCAAGGAACAGTAGTAACACCATTTTATGATTCATTACTAGTAA
AATTATGTACTTGGGGAATGACATTTGAGCAAGCAACGCGCAAAATGCGTCGTAACCTGATCGAATTCCG
TATCCGCGGTGTCAAAACGAACATTCCTTTCTTATTGAATGTAGTTCGTCATCCAGATTTTGCGAGTGGT
AATTACAATACAAGCTTTATCGATACAACTCCGGAACTATTTAAATTTCCACATATTCGCGACCGTGGTA
CGAAAACGTTGCGTTATATTGGTAATGTAACTGTTAATGGTTTCCCAGGAATTAAGCACCGTGATAAACC
TGTTTATGCAGAACCACGTTTGCCAAAAATTCCTTATGGTTCGCAAATCTCTCCAGGAACAAAACAAATT
TTGGATGCAAAAGGTCCAGAAGGCGTTGTCGACTGGGTGAAAAAACAAGAAGAAGTACTTTTGACAGATA
CTACGCTTCGAGATGCACATCAATCTCTACTTGCGACACGTGTTCGTTCAAAAGATATTTTTCAAGTGGC
AGACGCAATGGCACATTTATTACCAAATATGTTCTCATTTGAAATGTGGGGAGGGGCGACTTTTGACGTG
GCATATCGTTTCCTAAATGAAGATCCATGGGTGCGCCTAGAAACACTTAGAAAACAAATTCCAAATGTGA
TGTTCCAAATGTTACTTCGCGGAGCTAATGCAGTTGGGTATAAAAACTACCCTGACAATGTTATCCGTGA
ATTCGTTAAGCAATCAGCACAATCCGGTGTCGATGTATTCCGCGTGTTTGACAGCTTAAACTGGATCAAA
GGCATGGAAGTGTCCATTGATGCTGTTCGTGAAGCAGGGAAGGTCGTAGAGGCTGCTATCTGCTATACAG
GAGATATCGATGATGACACAAGAACGAAATATACGATTGATTACTATAAAGATATGGCGAAAGAGCTCGT
TGCTCAAGGTACGCATATTTTAGGCATTAAAGATATGGCTGGACTTTTAAAACCACAAGCAGCTTACCGT
TTAATTGGTGAATTAAAAGATACAGTGGATGTTCCAATCCACCTTCATACACATGACACAAGCGGCAACG
GTATTTATACTTACGCAGCAGCAGTCAGTGCAGGAGTTGACATTGTGGATGTTGCATCAAGCGCGATGAG
TGGGGCTACAAGCCAACCAAGTATGACTGGTCTTTACTACGGATTAGTGAATGGTAACCGTCAAACGAAC
TTAGACGCTCAAAATTCCCAAATCATTAATCATTACTGGGAAGATGTCCGTCACTATTATAAAGACTTTG
ACAATGCGCTTAATTCACCTCAAACAGAAGTATACATTCATGAAATGCCAGGTGGTCAATATACTAACCT
TCAACAACAAGCCATTGCAGTTGGACTTGGCGATCGTTGGGACGAAGTGAAAGAAATGTATACAGTGGTT
AATCAAATGTTTGGTGATATCGTTAAAGTAACACCTTCTTCCAAAGTTGTTGGAGACTTGGCGCTATTCA
TGGTTCAAAATGAATTATCCGAAGAAGATGTATATGAAAAAGGCGATACCATTGATTTCCCAGATTCCGT
TATCGAATTCTTTATGGGGGAAATTGGTCAACCATACGGCGGCTTCCCAGAAAAACTTCAAAAACTAGTA
CTCAAAGGACGTACACCACTTACAGATCGTCCAGGCGCTTTAATGGAGCCAGTTAACTTTGTTGATGTCA
AAGCAGAATTAAAAGAAAAAATGGGTTATGAACCAACTGAAAAAGATGTCATTTCCTATATTTTATATCC
AAAAGTGTTCCTAGATTATCAAGATATGATTAACAAATATGGTGATGTAACAGTCCTTGATACACCGACA
TTCTATAAAGGAATGCGTTTAGGGGAAACAATCGAAGTAGAACTTGAAAAAGGAAAAATCCTTTTAATCA
AGCTAAATTCCATTGGTGAACCAATTGCGGATGGCACACGTGTTATCTATTTTGAATTAAATGGACAACC
ACGTGAGATTAACATCCAAGATATGAACGTTCAATCCACTGTTATTGCACGCCGTAAGATTGATACAACT
AACCCTGAACATGTTGGAGCGACAATGACAGGTTCAGTCATTCAAGTTGTTGTGAAAAAAGGCGACTCTG
TGAAAAAAGGAGATCCACTACTAATCACAGAAGCAATGAAAATGGAAACAACGATTCAAGCGCCTTTCGA
TGGAGAAGTTAGCAGCATTTATGTTTCTGACGGCGATACTATCGAATCTGGTGATCTATTAATTGAAGTA
AACAGAATTTA
Protein Sequence 
>gi|284994546|ref|YP_003416314.1| pyruvate carboxylase [Listeria monocytogenes 08-5923] MNRIKKVLVANRGEIAIRVMRACTELKIKTVAIYSQEDTGSFHRYKSDEAYLVGAGKKPIDAYLDIENIIEIAKESGADAIHPGYGFLSENIEFARRCEQEGIIFVGPKSKHLDMFGDKIKAKEQALLADIPVIPGSNGPVAGIKEVEEFGEKNGYPLMIKASLGGGGRGMRVVESKEHVKESFERASSEAKAAFGNDEVYVEKCVMNPKHIEVQILGDTHGNIVHLFERDCSIQRRHQKVVEVAPCNAITSELRNRICDAAVKLMKNVDYINAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITGIDIVQSQLFIADGYALHDQLVAIPKQEDIHIHGSAIQSRITTEDPLNNFMPDTGRVDTYRSTGGFGVRLDAGNGFQGTVVTPFYDSLLVKLCTWGMTFEQATRKMRRNLIEFRIRGVKTNIPFLLNVVRHPDFASGNYNTSFIDTTPELFKFPHIRDRGTKTLRYIGNVTVNGFPGIKHRDKPVYAEPRLPKIPYGSQISPGTKQILDAKGPEGVVDWVKKQEEVLLTDTTLRDAHQSLLATRVRSKDIFQVADAMAHLLPNMFSFEMWGGATFDVAYRFLNEDPWVRLETLRKQIPNVMFQMLLRGANAVGYKNYPDNVIREFVKQSAQSGVDVFRVFDSLNWIKGMEVSIDAVREAGKVVEAAICYTGDIDDDTRTKYTIDYYKDMAKELVAQGTHILGIKDMAGLLKPQAAYRLIGELKDTVDVPIHLHTHDTSGNGIYTYAAAVSAGVDIVDVASSAMSGATSQPSMTGLYYGLVNGNRQTNLDAQNSQIINHYWEDVRHYYKDFDNALNSPQTEVYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIVKVTPSSKVVGDLALFMVQNELSEEDVYEKGDTIDFPDSVIEFFMGEIGQPYGGFPEKLQKLVLKGRTPLTDRPGALMEPVNFVDVKAELKEKMGYEPTEKDVISYILYPKVFLDYQDMINKYGDVTVLDTPTFYKGMRLGETIEVELEKGKILLIKLNSIGEPIADGTRVIYFELNGQPREINIQDMNVQSTVIARRKIDTTNPEHVGATMTGSVIQVVVKKGDSVKKGDPLLITEAMKMETTIQAPFDGEVSSIYVSDGDTIESGDLLIEVNRI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice (Schär et al., 2010).
COG COG1038C, under C: Energy production and conversion
References
Schär et al., 2010: Schär J, Stoll R, Schauer K, Loeffler DI, Eylert E, Joseph B, Eisenreich W, Fuchs TM, Goebel W. Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes. Journal of bacteriology. 2010; 192(7); 1774-1784. [PubMed: 20097852].