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hly from Listeria monocytogenes EGD-e

Victor ID 529
Gene Name hly from Listeria monocytogenes EGD-e
Sequence Strain (Species/Organism) Listeria monocytogenes EGD-e
NCBI Gene ID 987033
NCBI Protein GI 16802248
Locus Tag lmo0202
Protein Accession NP_463733.1
Other Database IDs UniProtKB-ID: TACY_LISMO
UniRef100: UniRef100_D2NZ73
UniRef90: UniRef90_D2NZ73
UniRef50: UniRef50_Q724L1
UniParc: UPI0000054E10
EMBL: X15127
EMBL: M24199
EMBL: X60035
EMBL: U25446
EMBL: U25449
EMBL: U25452
EMBL: AL591974
EMBL-CDS: CAA33223.1
EMBL-CDS: AAA03018.1
EMBL-CDS: CAA42639.1
EMBL-CDS: AAA69528.1
EMBL-CDS: AAA69531.1
EMBL-CDS: AAA69534.1
EMBL-CDS: CAD00729.1
RefSeq_NT: NC_003210.1
TCDB: 1.C.12.1.7
GenomeReviews: AL591824_GR
KEGG: lmo:lmo0202
GenoList: LMO0202
HOGENOM: HBG337470
OMA: GAYVA
Taxonomy ID 169963
Gene Starting Position 205818
Gene Ending Position 207407
Gene Strand (Orientation) +
Protein Name listeriolysin O precursor
DNA Sequence 
>gi|16802048:205818-207407 Listeria monocytogenes EGD-e, complete genome
CATGAAAAAAATAATGCTAGTTTTTATTACACTTATATTAGTTAGTCTACCAATTGCGCAACAAACTGAA
GCAAAGGATGCATCTGCATTCAATAAAGAAAATTCAATTTCATCCATGGCACCACCAGCATCTCCGCCTG
CAAGTCCTAAGACGCCAATCGAAAAGAAACACGCGGATGAAATCGATAAGTATATACAAGGATTGGATTA
CAATAAAAACAATGTATTAGTATACCACGGAGATGCAGTGACAAATGTGCCGCCAAGAAAAGGTTACAAA
GATGGAAATGAATATATTGTTGTGGAGAAAAAGAAGAAATCCATCAATCAAAATAATGCAGACATTCAAG
TTGTGAATGCAATTTCGAGCCTAACCTATCCAGGTGCTCTCGTAAAAGCGAATTCGGAATTAGTAGAAAA
TCAACCAGATGTTCTCCCTGTAAAACGTGATTCATTAACACTCAGCATTGATTTGCCAGGTATGACTAAT
CAAGACAATAAAATCGTTGTAAAAAATGCCACTAAATCAAACGTTAACAACGCAGTAAATACATTAGTGG
AAAGATGGAATGAAAAATATGCTCAAGCTTATCCAAATGTAAGTGCAAAAATTGATTATGATGACGAAAT
GGCTTACAGTGAATCACAATTAATTGCGAAATTTGGTACAGCATTTAAAGCTGTAAATAATAGCTTGAAT
GTAAACTTCGGCGCAATCAGTGAAGGGAAAATGCAAGAAGAAGTCATTAGTTTTAAACAAATTTACTATA
ACGTGAATGTTAATGAACCTACAAGACCTTCCAGATTTTTCGGCAAAGCTGTTACTAAAGAGCAGTTGCA
AGCGCTTGGAGTGAATGCAGAAAATCCTCCTGCATATATCTCAAGTGTGGCGTATGGCCGTCAAGTTTAT
TTGAAATTATCAACTAATTCCCATAGTACTAAAGTAAAAGCTGCTTTTGATGCTGCCGTAAGCGGAAAAT
CTGTCTCAGGTGATGTAGAACTAACAAATATCATCAAAAATTCTTCCTTCAAAGCCGTAATTTACGGAGG
TTCCGCAAAAGATGAAGTTCAAATCATCGACGGCAACCTCGGAGACTTACGCGATATTTTGAAAAAAGGC
GCTACTTTTAATCGAGAAACACCAGGAGTTCCCATTGCTTATACAACAAACTTCCTAAAAGACAATGAAT
TAGCTGTTATTAAAAACAACTCAGAATATATTGAAACAACTTCAAAAGCTTATACAGATGGAAAAATTAA
CATCGATCACTCTGGAGGATACGTTGCTCAATTCAACATTTCTTGGGATGAAGTAAATTATGATCCTGAA
GGTAACGAAATTGTTCAACATAAAAACTGGAGCGAAAACAATAAAAGCAAGCTAGCTCATTTCACATCGT
CCATCTATTTGCCAGGTAACGCGAGAAATATTAATGTTTACGCTAAAGAATGCACTGGTTTAGCTTGGGA
ATGGTGGAGAACGGTAATTGATGACCGGAACTTACCACTTGTGAAAAATAGAAATATCTCCATCTGGGGC
ACCACGCTTTATCCGAAATATAGTAATAAAGTAGATAATCCAATCGAATA
Protein Sequence 
>gi|16802248|ref|NP_463733.1| listeriolysin O precursor [Listeria monocytogenes EGD-e] MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell (Glomski et al., 2002).
References
Glomski et al., 2002: Glomski IJ, Gedde MM, Tsang AW, Swanson JA, Portnoy DA. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. The Journal of cell biology. 2002; 156(6); 1029-1038. [PubMed: 11901168].