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pycA from Listeria monocytogenes serotype 4b str. CLIP 80459

Victor ID 3811
Gene Name pycA from Listeria monocytogenes serotype 4b str. CLIP 80459
Sequence Strain (Species/Organism) Listeria monocytogenes serotype 4b str. CLIP 80459
NCBI Gene ID 7702259
NCBI Protein GI 226223686
Locus Tag Lm4b_01088
Protein Accession YP_002757793.1
Taxonomy ID 634178
Gene Starting Position 1095882
Gene Ending Position 1099322
Gene Strand (Orientation) +
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|226222639:1095882-1099322 Listeria monocytogenes Clip81459, complete genome
AATGAATCGAATTAAAAAAGTATTAGTAGCAAACCGCGGAGAAATTGCTATCCGTGTTATGCGTGCGTGT
ACTGAACTCAAAATCAAAACAGTGGCTATTTATTCACAAGAAGATACCGGAAGTTTTCACCGGTATAAAT
CAGATGAAGCTTATCTGGTTGGAGCAGGGAAAAAGCCTATTGATGCGTATCTAGATATCGAAAACATAAT
AGAGATTGCTAAAGAATCTGGTGCAGACGCGATTCATCCGGGATATGGTTTCTTGTCCGAAAACATTGAA
TTTGCTCGTCGTTGTGAGCAAGAAGGCATTATTTTCGTTGGTCCTAAATCAAAACACCTAGATATGTTTG
GTGATAAAATCAAAGCAAAAGAACAAGCTCTATTGGCTGATATTCCAGTAATTCCGGGAAGTAATGGACC
CGTGGCTGGTATTAAAGAAGTAGAAGAATTTGGTGAGAAAAACGGTTACCCATTAATGATTAAAGCTTCT
CTTGGAGGCGGCGGTCGTGGTATGCGTGTCGTAGAATCAAAAGAACATGTCAAAGAAAGCTTTGAACGTG
CATCCTCAGAAGCAAAAGCGGCATTTGGGAACGATGAAGTATACGTAGAAAAATGCGTGATGAATCCGAA
ACATATCGAAGTACAAATTCTTGGTGACACCCATGGCAACATCGTTCATTTATTTGAACGTGATTGTTCT
ATCCAACGTCGTCATCAAAAAGTAGTAGAGGTAGCGCCATGTAATGCGATTACTTCTGAACTACGTAACC
GTATCTGTGATGCTGCAGTAAAATTAATGAAAAATGTTGATTACATTAATGCTGGAACAGTTGAATTTTT
AGTGGAAGGCGATGATTTCTACTTTATCGAAGTAAATCCTCGTGTCCAAGTGGAGCATACAATTACTGAA
ATGATTACAGGGATTGATATTGTTCAATCACAACTATTCATTGCAGATGGTTACGCGCTTCACGACCAAC
TAGTAGCTATTCCTAAGCAAGAGGATATCCATATTCACGGTTCTGCTATTCAAAGCCGTATTACAACGGA
AGATCCACTTAATAACTTTATGCCAGATACTGGTCGAGTAGATACGTATCGCTCTACAGGTGGGTTTGGA
GTTCGGTTGGATGCTGGTAACGGCTTCCAAGGAACAGTAGTAACACCATTTTATGATTCCTTACTTGTAA
AATTATGTACTTGGGGAATGACATTCGAACAAGCAACGCGCAAAATGCGTCGTAACTTAATTGAATTCCG
TATCCGTGGTGTCAAAACGAACATTCCTTTCTTATTAAATGTTGTTCGTCATCCGGATTTTGCAAGTGGT
AATTATAATACAAGCTTTATTGATACAACACCGGAACTATTTAAATTCCCACATATTCGCGACCGTGGTA
CAAAAACGTTGCGTTATATTGGTAATGTAACGGTTAATGGTTTCCCAGGAATTAAGCACCGTGATAAACC
TGTATATGCAGAACCACGCTTGCCAAAAATTCCGTACGGTTCGCAAATCTCTCCAGGAACAAAACAAATT
TTGGATGCAAAAGGTCCAGAAGGCGTTGTAGACTGGGTGAAAAAACAAGAAGAAGTGCTCTTAACAGACA
CTACACTTCGGGATGCGCACCAATCTTTACTTGCAACACGTGTTCGCTCGAAAGACATTTTCCAAATAGC
AGATGCGATGGCTCATTTATTACCAAACATGTTTTCATTTGAAATGTGGGGTGGCGCGACTTTTGACGTG
GCATATCGTTTCCTAAATGAAGATCCTTGGGTGCGCCTAGAGACACTTAGAAAACAAATTCCAAACGTGA
TGTTCCAAATGTTACTTCGCGGAGCTAATGCAGTTGGGTATAAAAACTATCCTGACAATGTTATCCGTGA
ATTCGTTAAGCAATCAGCACAATCCGGTGTGGATGTATTCCGCGTGTTTGACAGCTTAAACTGGATCAAA
GGCATGGAAGTGTCCATTGATGCTGTTCGTGAAGCAGGGAAGATCGTAGAGGCTGCTATCTGCTATACAG
GAGATATCGATGATGACACAAGAACGAAATATACCATAGATTACTATAAAGATATGGCGAAAGAGCTCGT
TGCTCAAGGCACGCATATCCTAGGAATCAAAGATATGGCTGGGCTTTTAAAACCACAAGCGGCATACCGT
TTGATTGGTGAATTAAAAGATACAGTAGATGTTCCAATCCACCTTCACACGCATGACACAAGCGGTAACG
GTATTTATACTTACGCAGCAGCTGTCAGTGCTGGCGTTGACATTGTGGACGTGGCATCAAGCGCAATGAG
TGGGGCTACAAGCCAACCAAGTATGACTGGTCTTTATTACGGATTAGTGAATGGTAATCGTCAAACGAAT
TTAGACGCTCAAAATTCCCAAATCATTAATCATTACTGGGAAGATGTTCGTCACTATTACAAAGACTTTG
ACAATGCACTTAATTCACCTCAAACAGAAGTATACATTCATGAAATGCCAGGTGGTCAATATACTAACCT
TCAACAACAAGCCATTGCAGTTGGACTTGGCGACCGTTGGGACGAAGTGAAAGAAATGTATACAGTGGTT
AATCAAATGTTTGGTGATATCGTTAAAGTAACACCTTCTTCCAAAGTTGTTGGAGACTTAGCACTATTTA
TGGTTCAAAATGAATTATCCGAAGAAGATGTATACGAAAAAGGCGATACCATTGATTTCCCAGATTCCGT
TATCGAATTCTTTATGGGGGAAATTGGTCAACCATACGGCGGCTTCCCAGAAAAACTTCAAAAACTAGTA
CTCAAAGGACGTACACCACTTACAGATCGTCCAGGCGCTTTAATGGAACCAGTTAACTTTGTTGAAGTCA
AAGCAGAATTAAAAGAAAAAATGGGTTATGAACCAACTGAAAAAGATGTCATTTCCTATATTTTGTATCC
AAAAGTGTTCCTAGATTATCAAGAAATGATTAATAAATATGGTGATGTAACAGTCCTTGATACACCAACA
TTCTATAAAGGAATGCGTTTAGGGGAAACAATCGAAGTAGAACTTGAAAAAGGGAAAATCCTTTTAATCA
AGCTAAATTCTATTGGTGAACCAATTGCGGATGGCACACGTGTTATCTATTTTGAATTAAATGGACAACC
ACGTGAGATTAACATCCAAGATATGAACGTTCAATCCACTGTTATTGCACGCCGTAAGATTGATACAACT
AACCCTGAACATGTTGGAGCTACAATGACAGGTTCAGTCATTCAAGTAGTTGTTAAAAAAGGCGACTCTG
TTAAAAAAGGTGATCCACTACTAATCACAGAAGCAATGAAAATGGAAACAACGATTCAAGCGCCTTTCGA
TGGAGAAGTTAGCAGCATTTATGTTTCTGACGGCGATACTATCGAATCTGGTGATCTTTTAATTGAAGTA
AACAGAATTTA
Protein Sequence 
>gi|226223686|ref|YP_002757793.1| pyruvate carboxylase [Listeria monocytogenes serotype 4b str. CLIP 80459] MNRIKKVLVANRGEIAIRVMRACTELKIKTVAIYSQEDTGSFHRYKSDEAYLVGAGKKPIDAYLDIENIIEIAKESGADAIHPGYGFLSENIEFARRCEQEGIIFVGPKSKHLDMFGDKIKAKEQALLADIPVIPGSNGPVAGIKEVEEFGEKNGYPLMIKASLGGGGRGMRVVESKEHVKESFERASSEAKAAFGNDEVYVEKCVMNPKHIEVQILGDTHGNIVHLFERDCSIQRRHQKVVEVAPCNAITSELRNRICDAAVKLMKNVDYINAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITGIDIVQSQLFIADGYALHDQLVAIPKQEDIHIHGSAIQSRITTEDPLNNFMPDTGRVDTYRSTGGFGVRLDAGNGFQGTVVTPFYDSLLVKLCTWGMTFEQATRKMRRNLIEFRIRGVKTNIPFLLNVVRHPDFASGNYNTSFIDTTPELFKFPHIRDRGTKTLRYIGNVTVNGFPGIKHRDKPVYAEPRLPKIPYGSQISPGTKQILDAKGPEGVVDWVKKQEEVLLTDTTLRDAHQSLLATRVRSKDIFQIADAMAHLLPNMFSFEMWGGATFDVAYRFLNEDPWVRLETLRKQIPNVMFQMLLRGANAVGYKNYPDNVIREFVKQSAQSGVDVFRVFDSLNWIKGMEVSIDAVREAGKIVEAAICYTGDIDDDTRTKYTIDYYKDMAKELVAQGTHILGIKDMAGLLKPQAAYRLIGELKDTVDVPIHLHTHDTSGNGIYTYAAAVSAGVDIVDVASSAMSGATSQPSMTGLYYGLVNGNRQTNLDAQNSQIINHYWEDVRHYYKDFDNALNSPQTEVYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIVKVTPSSKVVGDLALFMVQNELSEEDVYEKGDTIDFPDSVIEFFMGEIGQPYGGFPEKLQKLVLKGRTPLTDRPGALMEPVNFVEVKAELKEKMGYEPTEKDVISYILYPKVFLDYQEMINKYGDVTVLDTPTFYKGMRLGETIEVELEKGKILLIKLNSIGEPIADGTRVIYFELNGQPREINIQDMNVQSTVIARRKIDTTNPEHVGATMTGSVIQVVVKKGDSVKKGDPLLITEAMKMETTIQAPFDGEVSSIYVSDGDTIESGDLLIEVNRI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice (Schär et al., 2010).
COG COG1038C, under C: Energy production and conversion
References
Schär et al., 2010: Schär J, Stoll R, Schauer K, Loeffler DI, Eylert E, Joseph B, Eisenreich W, Fuchs TM, Goebel W. Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes. Journal of bacteriology. 2010; 192(7); 1774-1784. [PubMed: 20097852].