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hly from Listeria monocytogenes serotype 4b str. CLIP 80459

Victor ID 3822
Gene Name hly from Listeria monocytogenes serotype 4b str. CLIP 80459
Sequence Strain (Species/Organism) Listeria monocytogenes serotype 4b str. CLIP 80459
NCBI Gene ID 7704059
NCBI Protein GI 226222831
Locus Tag Lm4b_00200
Protein Accession YP_002756938.1
Taxonomy ID 634178
Gene Starting Position 202492
Gene Ending Position 204096
Gene Strand (Orientation) +
Protein Name listeriolysin O precursor
DNA Sequence 
>gi|226222639:202492-204096 Listeria monocytogenes Clip81459, complete genome
AAGGAGAGTGAAACCCATGAAAAAAATAATGCTAGTTTTTATTACACTTATATTAGTTAGTCTACCAATT
GCGCAACAAACTGAAGCAAAGGATGCATCTGCATTCCATAAAGAAAATTTAATTTCATCCATGGCACCAC
CAGCATCTCCGCCTGCAAGTCCTAAGACGCCAATCGAAAAGAAACACGCGGATGAAATCGATAAGTATAT
ACAAGGATTGGATTACAATAAAAACAATGTATTAGTATACCACGGAGATGCAGTGACAAATGTGCCGCCA
AGAAAAGGTTATAAAGATGGAAATGAATATATCGTTGTGGAGAAAAAGAAGAAATCCATCAATCAAAATA
ATGCAGATATCCAAGTTGTGAATGCAATTTCGAGCCTAACATATCCAGGTGCTCTCGTGAAAGCGAATTC
GGAATTAGTAGAAAATCAACCCGATGTTCTTCCTGTCAAACGTGATTCATTAACACTTAGCATTGATTTG
CCAGGAATGACTAATCAAGACAATAAAATTGTTGTAAAAAATGCTACTAAATCGAACGTTAACAACGCAG
TAAATACATTAGTGGAAAGATGGAATGAAAAATATGCTCAAGCTTATCCAAATGTAAGTGCAAAAATTGA
TTATGATGACGAAATGGCTTACAGTGAATCGCAATTAATTGCAAAATTTGGTACGGCATTTAAAGCTGTA
AATAATAGCTTGAATGTAAACTTCGGCGCAATCAGTGAAGGGAAAATGCAAGAAGAAGTCATTAGTTTTA
AACAAATTTACTATAACGTGAATGTTAATGAACCTACAAGACCTTCCAGATTTTTCGGCAAAGCTGTTAC
TAAAGAGCAGTTGCAAGCGCTTGGAGTGAATGCAGAAAATCCTCCTGCATATATCTCAAGTGTGGCATAT
GGCCGTCAAGTTTATTTGAAATTATCAACTAATTCCCATAGTACTAAAGTAAAAGCTGCTTTTGATGCTG
CCGTAAGTGGGAAATCTGTCTCAGGTGATGTAGAACTGACAAATATCATCAAAAATTCTTCCTTCAAAGC
CGTAATTTACGGTGGCTCCGCAAAAGATGAAGTTCAAATCATCGACGGTAACCTCGGAGACTTACGAGAT
ATTTTGAAAAAAGGTGCTACTTTTAACCGGGAAACACCAGGAGTTCCCATTGCCTATACAACAAACTTCT
TAAAAGACAATGAATTAGCTGTTATTAAAAACAACTCAGAATATATTGAAACAACTTCAAAAGCTTATAC
AGATGGAAAAATCAACATCGATCACTCTGGAGGATACGTTGCTCAATTCAACATCTCTTGGGATGAAATA
AATTATGATCCTGAAGGTAACGAAATTGTTCAACATAAAAACTGGAGCGAAAACAATAAAAGTAAGCTAG
CTCATTTCACATCGTCCATCTATTTGCCAGGTAACGCAAGAAATATTAATGTTTACGCTAAAGAATGCAC
TGGTTTAGCTTGGGAATGGTGGAGAACGGTAATTGATGACCGGAACCTACCGCTTGTGAAAAATAGAAAT
ATCTCCATCTGGGGCACTACACTTTATCCGAAATATAGTAATAGTGTAGATAATCCAATCGAATA
Protein Sequence 
>gi|226222831|ref|YP_002756938.1| listeriolysin O precursor [Listeria monocytogenes serotype 4b str. CLIP 80459] MKKIMLVFITLILVSLPIAQQTEAKDASAFHKENLISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell (Glomski et al., 2002).
References
Glomski et al., 2002: Glomski IJ, Gedde MM, Tsang AW, Swanson JA, Portnoy DA. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. The Journal of cell biology. 2002; 156(6); 1029-1038. [PubMed: 11901168].