| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
HP1206 |
Helicobacter |
898800
|
|
15645820
|
HP1206 |
|
NP_207998.1 |
multidrug resistance protein (hetA) |
Virulence factor |
MUTATION: a HP1206 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flgL |
Helicobacter |
898810
|
|
15644923
|
HP0295 |
|
NP_207093.1 |
flagellar hook-associated protein FlgL |
Virulence factor |
MUTATION: a flgL mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0350 |
Helicobacter |
898835
|
|
15644978
|
HP0350 |
|
NP_207148.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0350 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0758 |
Helicobacter |
898859
|
|
15645377
|
HP0758 |
|
NP_207551.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0758 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0392 |
Helicobacter |
898900
|
|
15645020
|
HP0392 |
|
NP_207190.1 |
histidine kinase (cheA) |
Virulence factor |
MUTATION: a HP03292 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0797 |
Helicobacter |
898975
|
|
15645416
|
HP0797 |
|
NP_207590.1 |
flagellar sheath adhesin hpaA |
Virulence factor |
MUTATION: a HP0797 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0169 |
Helicobacter |
899006
|
|
15644798
|
HP0169 |
|
NP_206968.1 |
collagenase (prtC) |
Virulence factor |
MUTATION: a HP0169 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0254 |
Helicobacter |
899058
|
|
15644882
|
HP0254 |
|
NP_207052.1 |
outer membrane protein (omp8) |
Virulence factor |
MUTATION: a HP0254 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0017 |
Helicobacter |
899097
|
|
15644650
|
HP0017 |
|
NP_206819.1 |
virB4 homolog (virB4) |
Virulence factor |
MUTATION: a HP0017 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
ureC |
Helicobacter |
899104
|
|
15644702
|
HP0072 |
|
NP_206872.1 |
urease subunit alpha |
Virulence factor |
MUTATION: a ureC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
hemC |
Helicobacter |
899174
|
|
15644865
|
HP0237 |
|
NP_207035.1 |
porphobilinogen deaminase |
Virulence factor |
MUTATION: a hemC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0055 |
Helicobacter |
899191
|
|
15644686
|
HP0055 |
|
NP_206856.1 |
proline permease (putP) |
Virulence factor |
MUTATION: a HP0055 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0289 |
Helicobacter |
899197
|
|
15644917
|
HP0289 |
|
NP_207087.1 |
toxin-like outer membrane protein |
Virulence factor |
MUTATION: a HP0289 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0360 |
Helicobacter |
899217
|
|
15644988
|
HP0360 |
|
NP_207158.1 |
UDP-glucose 4-epimerase |
Virulence factor |
MUTATION: a HP0360 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0366 |
Helicobacter |
899219
|
|
15644994
|
HP0366 |
|
NP_207164.1 |
spore coat polysaccharide biosynthesis protein C |
Virulence factor |
MUTATION: a HP0366 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliS |
Helicobacter |
899333
|
|
15645372
|
HP0753 |
|
NP_207546.1 |
flagellar protein FliS |
Virulence factor |
MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
HP0788 |
Helicobacter |
899346
|
|
15645407
|
HP0788 |
|
NP_207581.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0788 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flgE |
Helicobacter |
899399
|
|
15645489
|
HP0870 |
|
NP_207664.1 |
flagellar hook protein FlgE |
Virulence factor |
MUTATION: a flgE mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flgD |
Helicobacter |
899436
|
|
15645523
|
HP0907 |
|
NP_207699.1 |
flagellar basal body rod modification protein |
Virulence factor |
MUTATION: a flgD mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
surE |
Helicobacter |
899459
|
|
15645546
|
HP0930 |
|
NP_207722.1 |
stationary phase survival protein SurE |
Virulence factor |
MUTATION: a surE mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0973 |
Helicobacter |
899505
|
|
15645588
|
HP0973 |
|
NP_207764.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0973 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliM |
Helicobacter |
899566
|
|
15645645
|
HP1031 |
|
NP_207821.1 |
flagellar motor switch protein FliM |
Virulence factor |
MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
HP1082 |
Helicobacter |
899618
|
|
15645696
|
HP1082 |
|
NP_207873.1 |
multidrug resistance protein (msbA) |
Virulence factor |
MUTATION: a HP1082 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1091 |
Helicobacter |
899627
|
|
15645705
|
HP1091 |
|
NP_207882.1 |
alpha-ketoglutarate permease (kgtP) |
Virulence factor |
MUTATION: a HP1091 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1092 |
Helicobacter |
899628
|
|
15645706
|
HP1092 |
|
NP_207883.1 |
flagellar basal-body rod protein (flgG) |
Virulence factor |
MUTATION: a HP1092 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flgC |
Helicobacter |
899733
|
|
15646165
|
HP1558 |
|
NP_208349.1 |
flagellar basal body rod protein FlgC |
Virulence factor |
MUTATION: a flgC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1525 |
Helicobacter |
899766
|
|
15646133
|
HP1525 |
|
NP_208315.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP1525 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1506 |
Helicobacter |
899785
|
|
15646115
|
HP1506 |
|
NP_208297.1 |
glutamate permease (gltS) |
Virulence factor |
MUTATION: a HP1506 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1486 |
Helicobacter |
899806
|
|
15646095
|
HP1486 |
|
NP_208277.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP1486 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP1421 |
Helicobacter |
899874
|
|
15646030
|
HP1421 |
|
NP_208212.1 |
conjugative transfer regulon protein (trbB) |
Virulence factor |
MUTATION: a HP1421 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliI |
Helicobacter |
899875
|
|
15646029
|
HP1420 |
|
NP_208211.1 |
flagellum-specific ATP synthase |
Virulence factor |
MUTATION: a fliI mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliQ |
Helicobacter |
899876
|
|
15646028
|
HP1419 |
|
NP_208210.1 |
flagellar biosynthesis protein FliQ |
Virulence factor |
MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
HP0601 |
Helicobacter |
899977
|
|
15645226
|
HP0601 |
|
NP_207396.1 |
flagellin A |
Virulence factor |
MUTATION: a HP0601 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliP |
Helicobacter |
899979
|
|
15645308
|
HP0685 |
|
NP_207479.1 |
flagellar biosynthesis protein FliP |
Virulence factor |
MUTATION: a fliP mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0067 |
Helicobacter |
899986
|
|
15644697
|
HP0067 |
|
NP_206867.1 |
urease accessory protein (ureH) |
Virulence factor |
MUTATION: a HP0067 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0071 |
Helicobacter |
899995
|
|
15644701
|
HP0071 |
|
NP_206871.1 |
urease accessory protein (ureI) |
Virulence factor |
MUTATION: a HP0071 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0393 |
Helicobacter |
899996
|
|
15645021
|
HP0393 |
|
NP_207191.1 |
chemotaxis protein (cheV) |
Virulence factor |
MUTATION: a HP0393 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliD |
Helicobacter |
900004
|
|
15645371
|
HP0752 |
|
NP_207545.1 |
flagellar capping protein |
Virulence factor |
MUTATION: a fliD mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0486 |
Helicobacter |
900059
|
|
15645113
|
HP0486 |
|
NP_207283.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0486 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0288 |
Helicobacter |
900108
|
|
15644916
|
HP0288 |
|
NP_207086.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0288 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0245 |
Helicobacter |
900123
|
|
15644873
|
HP0245 |
|
NP_207043.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0245 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0073 |
Helicobacter |
900171
|
|
15644703
|
HP0073 |
|
NP_206873.1 |
bifunctional urease subunit gamma/beta |
Virulence factor |
MUTATION: a HP0073 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0232 |
Helicobacter |
900177
|
|
15644860
|
HP0232 |
|
NP_207030.1 |
hypothetical protein |
Virulence factor |
MUTATION: a HP0232 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0302 |
Helicobacter |
900194
|
|
15644930
|
HP0302 |
|
NP_207100.1 |
dipeptide ABC transporter, ATP-binding protein (dppF) |
Virulence factor |
MUTATION: a HP0302 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flgH |
Helicobacter |
900196
|
|
15644953
|
HP0325 |
|
NP_207123.1 |
flagellar basal body L-ring protein |
Virulence factor |
MUTATION: a flgH mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0397 |
Helicobacter |
900244
|
|
15645025
|
HP0397 |
|
NP_207195.1 |
phosphoglycerate dehydrogenase (serA) |
Virulence factor |
MUTATION: a HP0397 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
HP0714 |
Helicobacter |
900248
|
|
15645336
|
HP0714 |
|
NP_207508.1 |
RNA polymerase factor sigma-54 |
Virulence factor |
MUTATION: a HP0714 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
fliF |
Helicobacter |
900354
|
|
15644979
|
HP0351 |
|
NP_207149.1 |
flagellar MS-ring protein |
Virulence factor |
MUTATION: a fliF mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] |
12668646
|
|
|
flaA |
Helicobacter |
889160
|
|
15611615
|
jhp0548 |
|
NP_223266.1 |
flagellin A |
Virulence factor |
MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
cagA |
Helicobacter |
889201
|
|
15611562
|
jhp0495 |
|
NP_223213.1 |
cag island protein, CYTOTOXICITY ASSOCIATED IMMUNODOMINANT ANTIGEN |
Virulence factor |
MUTATION: attenuated in monkeys [Ref6335:Hornsby et al., 2008]. |
18395086
|
|
|
cagP |
Helicobacter |
889236
|
|
15611551
|
jhp0484 |
|
NP_223202.1 |
cag island protein |
Virulence factor |
MUTATION: mutant strain adhered less to AGS cells than wild-type strain [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
napA |
Helicobacter |
889403
|
|
15611298
|
jhp0228 |
|
NP_222949.1 |
NEUTROPHIL-ACTIVATING PROTEIN A |
Virulence factor |
MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. |
16758245
|
|
|
flaB |
Helicobacter |
889505
|
|
15611177
|
jhp0107 |
|
NP_222828.1 |
flagellin |
Virulence factor |
MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
babA |
Helicobacter |
890058
|
|
15611900
|
jhp0833 |
|
NP_223551.1 |
outer membrane protein - adhesin |
Virulence factor |
MUTATION: modified strain eliminated binding to LEB and gastric tissue [Ref6337:Styer et al., 2010]. |
20123715
|
|
|
vacA |
Helicobacter |
890075
|
|
15611886
|
jhp0819 |
|
NP_223537.1 |
vacuolating cytotoxin |
Virulence factor |
MUTATION: knockout did not result in gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. |
20046046
|
|
|
ureG |
Helicobacter |
890411
|
|
15611134
|
jhp0063 |
|
NP_222785.1 |
UREASE ACCESSORY PROTEIN |
Virulence factor |
MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. |
8063376
|
|
|
flaA |
Helicobacter |
7009743
|
|
210134803
|
HPP12_0609 |
|
YP_002301242.1 |
flagellin A |
Virulence factor |
MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
hopH |
Helicobacter |
7009784
|
|
210134844
|
HPP12_0650 |
|
YP_002301283.1 |
outer membrane protein HopH |
Virulence factor |
MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. |
17054063
|
|
|
homB |
Helicobacter |
7009855
|
|
210134914
|
HPP12_0721 |
|
YP_002301353.1 |
outer membrane protein HomB |
Virulence factor |
MUTATION: knockout strains reduced damage and adherence to human gastric epithelial cells [Ref6803:Oleastro et al., 2008]. |
18811585
|
|
|
vacA |
Helicobacter |
7010020
|
|
210135077
|
HPP12_0884 |
|
YP_002301516.1 |
vacuolating cytotoxin VacA |
Virulence factor |
MUTATION: knockout did not cause gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. |
20046046
|
|
|
babA |
Helicobacter |
7010027
|
|
210135084
|
HPP12_0891 |
|
YP_002301523.1 |
outer membrane protein BabA |
Virulence factor |
MUTATION: strains slacking BabA cannot adhere to Leb, expressed on gastric epithelium [Ref6804:Solnick et al., 2004]. |
14762173
|
|
|
alpA |
Helicobacter |
7010048
|
|
210135103
|
HPP12_0910 |
|
YP_002301542.1 |
outer membrane protein HopC/AlpA |
Virulence factor |
MUTATION: mutant showed severe reduction in ability to bind to gastric cell line [Ref6805:Odenbreit et al., 1999]. |
10200971
|
|
|
alpB |
Helicobacter |
7010049
|
|
210135104
|
HPP12_0911 |
|
YP_002301543.1 |
outer membrane protein HopB/AlpB |
Virulence factor |
MUTATION: mutant showed severe reduction in ability to bind to gastric cell line [Ref6805:Odenbreit et al., 1999]. |
10200971
|
|
|
hopZ |
Helicobacter |
7010375
|
|
210134208
|
HPP12_0007 |
|
YP_002300647.1 |
outer membrane protein HopZ |
Virulence factor |
MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. |
10454640
|
|
|
ureG |
Helicobacter |
7010440
|
|
210134273
|
HPP12_0072 |
|
YP_002300712.1 |
urease accessory protein UreG |
Virulence factor |
MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. |
8063376
|
|
|
flaB |
Helicobacter |
7010487
|
|
210134318
|
HPP12_0117 |
|
YP_002300757.1 |
flagellin B |
Virulence factor |
MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
horB |
Helicobacter |
7010497
|
|
210134328
|
HPP12_0127 |
|
YP_002300767.1 |
outer membrane protein HorB |
Virulence factor |
MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. |
17492999
|
|
|
napA |
Helicobacter |
7010614
|
|
210134443
|
HPP12_0243 |
|
YP_002300882.1 |
neutrophil-activating protein A |
Virulence factor |
MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. |
16758245
|
|
|
cagP |
Helicobacter |
7010918
|
|
210134738
|
HPP12_0543 |
|
YP_002301177.1 |
cag pathogenicity island protein P |
Virulence factor |
MUTATION: mutant strain adhered less to AGS cells than wild-type strain [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
cagE |
Helicobacter |
7010926
|
|
210134746
|
HPP12_0551 |
|
YP_002301185.1 |
cag pathogenicity island protein E VirB4-like protein |
Virulence factor |
MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils [Ref6808:Ogura et al., 2000]. |
11104802
|
|
|
hopZ |
Helicobacter |
6962890
|
|
208433984
|
HPG27_8 |
|
YP_002265650.1 |
outer membrane protein |
Virulence factor |
MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. |
10454640
|
|
|
ureG |
Helicobacter |
6962945
|
|
208434035
|
HPG27_63 |
|
YP_002265701.1 |
urease accessory protein |
Virulence factor |
MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. |
8063376
|
|
|
flaB |
Helicobacter |
6962991
|
|
208434076
|
HPG27_107 |
|
YP_002265742.1 |
flagellin B |
Virulence factor |
MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
horB |
Helicobacter |
6963000
|
|
208434085
|
HPG27_116 |
|
YP_002265751.1 |
outer membrane protein |
Virulence factor |
MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. |
17492999
|
|
|
babA |
Helicobacter |
6963184
|
|
208434264
|
HPG27_298 |
|
YP_002265930.1 |
outer membrane protein |
Virulence factor |
MUTATION: strains lacking BabA cannot adhere to Leb, expressed on gastric epithelium [Ref6804:Solnick et al., 2004]. |
14762173
|
|
|
cagE |
Helicobacter |
6963392
|
|
208434465
|
HPG27_503 |
|
YP_002266131.1 |
cag pathogenicity island protein E |
Virulence factor |
MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils [Ref6808:Ogura et al., 2000]. |
11104802
|
|
|
flaA |
Helicobacter |
6963451
|
|
208434522
|
HPG27_562 |
|
YP_002266188.1 |
flagellin A |
Virulence factor |
MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
hopH |
Helicobacter |
6963488
|
|
208434559
|
HPG27_599 |
|
YP_002266225.1 |
outer membrane protein |
Virulence factor |
MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. |
17054063
|
|
|
sabA |
Helicobacter |
6963569
|
|
208434635
|
HPG27_680 |
|
YP_002266301.1 |
outer membrane protein |
Virulence factor |
MUTATION: deletion mutant lost ability to bind to sialyl-Lewis antigens [Ref6809:Aspholm et al., 2006], and had no neutrophil-activating capacity [Ref6810:Unemo et al., 2005]. |
17121461
15689619
|
|
|
vacA |
Helicobacter |
6963731
|
|
208434795
|
HPG27_840 |
|
YP_002266461.1 |
vacuolating cytotoxin A |
Virulence factor |
MUTATION: knockout did not cause gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. |
20046046
|
|
|
flaB |
Helicobacter |
8207576
|
|
254778835
|
HELPY_0115 |
|
YP_003056940.1 |
Flagellin B (Flagellin N) |
Virulence factor |
MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
napA |
Helicobacter |
8207634
|
|
254778949
|
HELPY_0248 |
|
YP_003057054.1 |
Neutrophil activating protein NapA (bacterioferritin) |
Virulence factor |
MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. |
16758245
|
|
|
hopH |
Helicobacter |
8207891
|
|
254779375
|
HELPY_0733 |
|
YP_003057480.1 |
Outer membrane protein HopH |
Virulence factor |
MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. |
17054063
|
|
|
hopZ |
Helicobacter |
8208349
|
|
254778745
|
HELPY_0007 |
|
YP_003056850.1 |
Outer membrane protein HopZ; putative signal peptide |
Virulence factor |
MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. |
10454640
|
|
|
flaA |
Helicobacter |
8208748
|
|
254779405
|
HELPY_0771 |
|
YP_003057510.1 |
Flagellin A |
Virulence factor |
MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. |
8698465
|
|
|
tlyA |
Helicobacter |
8208922
|
|
254779055
|
HELPY_0367 |
|
YP_003057160.1 |
Pore-forming cytolysin |
Virulence factor |
MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. |
12018657
|
|
|
horB |
Helicobacter |
8208956
|
|
254778844
|
HELPY_0126 |
|
YP_003056949.1 |
Outer membrane protein HorB; putative signal peptide |
Virulence factor |
MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. |
17492999
|
|
|
ureG |
Helicobacter |
8209081
|
|
254778794
|
HELPY_0064 |
|
YP_003056899.1 |
Urease accessory protein UreG |
Virulence factor |
MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. |
8063376
|
|
|
HP0859 |
Helicobacter pylori 26695 |
899388
|
|
15645478
|
HP0859 |
AE000511 |
NP_207653 |
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) |
Virulence factor |
MUTATION: HP0859 knockout mutant exhibited a severe truncation of LPS, a decreased growth rate, and a higher susceptibility to novobiocin. Disruption of HP0859 also reduced the adhesive capacity of H. pylori to AGS cells [Ref7282:Chang et al., 2011]. |
21256827
|
|
|
LPS |
Helicobacter pylori |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: Insertional inactivation of HP0479 resulted in formation of a truncated LPS molecule lacking an alpha-1,6-glucan-, dd-heptose-containing outer core region and O-chain polysaccharide. Introduction of the HP0479 mutation into the H. pylori mouse-colonizing Sydney (SS1) strain and the clinical isolate PJ1, which expresses dd-heptoglycan, resulted in the loss of colonization in a mouse model [Ref7296:Hiratsuka et al., 2005]. |
16030209
|
