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HP0169

Victor ID 353
Gene Name HP0169
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 899006
NCBI Protein GI 15644798
Locus Tag HP0169
Protein Accession NP_206968.1
Other Database IDs UniProtKB-ID: Y169_HELPY
UniRef100: UniRef100_P56113
UniRef90: UniRef90_Q9ZMR3
UniRef50: UniRef50_Q9ZMR3
UniParc: UPI00001393BF
EMBL: AE000511
EMBL-CDS: AAD07235.1
RefSeq_NT: NC_000915.1
MEROPS: U32.002
GenomeReviews: AE000511_GR
KEGG: hpy:HP0169
NMPDR: fig|85962.1.peg.166
TIGR: HP_0169
HOGENOM: HBG463792
OMA: DLRAVEH
ProtClustDB: CLSK872290
Taxonomy ID 85962
Gene Starting Position 175452
Gene Ending Position 176720
Gene Strand (Orientation) -
Protein Name collagenase (prtC)
DNA Sequence 
>gi|15644634:175452-176720 Helicobacter pylori 26695, complete genome
TTTAGACTCTGACTTGGGTGCGTAAAAAACTAAAAGCCGGTAAGGGTGCGGGCAGTCGCACTAAATTCAC
GTTCCCGCTATGGATAGTTTCTAGCTCGGTGTTATTTTCTAAAAGGATTTTATACAGCACTAAATAAGAG
CGTTTTTCAAAGGTGTAAATCTTGCCAATTTCATTGACTATGGGCGTGATAGCCGCATTTTTGGGAGCGA
TGATTTCATAAGCGGTGTTAGTGGTAGTGGTGAATTTGCATGCAAAAAAACGCCCGTCTTCGGTTATTTC
GCCATTGACTTGAAAATCCCCTTCGCTAATGGCTGTTTGGTGGTTTTGAGTATCCAACCTTTCAAAAGGC
CTTCGCATCAAATAGCCGTCCGTAAAACCCCTGTTTTTAAGCGTGTTCAATTCGCTGGCATAAAAACTCG
GCTTTAAGGTGTTATGGTAAAAATCATCAACCGCTAAACGATAGATGCGCGTGGTTTGCGCGGCGTAGTA
ACTGGACTTGGTGCGCCCTTCAATCTTAAGCGCGCTAATGGCGTTGGAACTTAAAATTTCAGCGATATGG
CCAGAGAGGTTCAAATCCTTAGCGTTAAAAATATGCGTGCCTACGCCCTCTTCTTCAACCAGTCTCATCA
TCACGCCATTATCAGGGTTTTTCACGTAATATTCATAATCAAACCGGCAATCATTCGCGCAACTCCCTCT
ATTAGGCACGCGCCCCTTTTGTAAGGCCGAAATCAAGCAGCGCCCTGAAAAGGCAAAGCACATGCTCCCA
TGCACAAAGATTTCTAATTCTAAATTAGGTAAGGCTTTTTTAATCTCAATCGCATCATTCAGGCTCAATT
CCCTCGCGCACACGATGCGTTTAACCCCTAAATCATAAAACACTTGTGCATCTAGCAAATTTAAGACATT
CGCTTGCGTGGATAAATGGATAGGGATATGCGGGGCGATTTTTAAAGCGAGTTTCACCACACCAGGCGCA
GCGATAATAAAAGCGTCCGGCTCTAATTCTGCCATTTTATCAATATGTTCTTCTAAAAGTTTGAGCTGTG
AATTGAAAGGGAAACCATTGATCGTGGCATAGACTTTTTTATTTAGCGCATGGGCGTAGTCAATCCCTTC
TTTGAAAGTTTCTAAAGTAAATTCCTTGCCTGCACGATTGCGTAAAGAAAAATGGCTCACTCCCCCATAA
ACCGCATCAGCCCCATAGTTGAGGGCGATTTTAAGTTTTTTTAAATTACCAGCTGGAGAGAGTAATTCAA
CTTGGTTCA
Protein Sequence 
>gi|15644798|ref|NP_206968.1| collagenase PrtC [Helicobacter pylori 26695] MNQVELLSPAGNLKKLKIALNYGADAVYGGVSHFSLRNRAGKEFTLETFKEGIDYAHALNKKVYATINGFPFNSQLKLLEEHIDKMAELEPDAFIIAAPGVVKLALKIAPHIPIHLSTQANVLNLLDAQVFYDLGVKRIVCARELSLNDAIEIKKALPNLELEIFVHGSMCFAFSGRCLISALQKGRVPNRGSCANDCRFDYEYYVKNPDNGVMMRLVEEEGVGTHIFNAKDLNLSGHIAEILSSNAISALKIEGRTKSSYYAAQTTRIYRLAVDDFYHNTLKPSFYASELNTLKNRGFTDGYLMRRPFERLDTQNHQTAISEGDFQVNGEITEDGRFFACKFTTTTNTAYEIIAPKNAAITPIVNEIGKIYTFEKRSYLVLYKILLENNTELETIHSGNVNLVRLPAPLPAFSFLRTQVRV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a HP0169 mutant was attenuated for gastric colonization in a gerbil model (Kavermann et al., 2003)
COG COG0826O, under O: Posttranslational modification, protein turnover, chaperones
References
Kavermann et al., 2003: Kavermann H, Burns BP, Angermuller K, Odenbreit S, Fischer W, Melchers K, Haas R. Identification and characterization of Helicobacter pylori genes essential for gastric colonization. The Journal of experimental medicine. 2003; 197(7); 813-822. [PubMed: 12668646].