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HP0859

Victor ID 4864
Gene Name HP0859
Sequence Strain (Species/Organism) Helicobacter pylori 26695
NCBI Gene ID 899388
NCBI Protein GI 15645478
Locus Tag HP0859
Genbank Accession AE000511
Protein Accession NP_207653
Taxonomy ID 85962
Gene Starting Position 912290
Gene Ending Position 913282
Gene Strand (Orientation) -
Protein Name ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD)
Protein pI 7.36
Protein Weight 35130.38
Protein Length 330
Protein Note similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative
DNA Sequence 
>gi|15644634:912290-913282 Helicobacter pylori 26695, complete genome
TTCATGCGCACTGTCCTTTAAAAATCGCATGGATATGGGGCAAATAATCTTTAATGCCGCTTTCCAAATC
GTATAAAGGGGTGTAATCCAAATCCAAAATAGCAGGCTCAATGTGTGCTTGGGTGTGCTTTTGGAAGAAA
GCATAAGGGTTTTTGATATAACTCACTTTAAAATCCCCTAAATGCTCTTTTAAAATGCTAACGATTTCAT
TATAACTTCTGGCTTGGGAATAACCCACATTATAAACCCCGCTTTTTTGAGCCTTCATCGCTTTCACGCT
CGCTTGGATCACATCTTCAATATAGACAAAATCCCTTAATTGCTCGCCAAATTCAAAAAGCTTGACTTCC
TTAAACGCCATCGCGCCTAAGGCGAGTTGCAAAACCATAGAGGCGGTTTTTTCTTTATAAAATTCCCTAG
GCCCATAGACATTAAAATACCTTAAGCCCACTTGAACATTGTCGTTTGAATGGGAGAGGACAAATTCATC
CATGCAAAGCTTGGAAAAGCCATAAACATTTTCAGGGCTTTCGTTTGAGCCTACCACATTGGGGGCTTTG
GTGTTGCCATAAACGCCCGCTGAAGAAGCGTAAATCACTTTAGCTTTTTTTGAGCGAGCGATTTCTAAAA
GGTTTAAAAAAGCCTGATAATTGGTCTTCATCACTAATTCTTGATCCAGCATGGTCGTATCAGAGACAGC
GGCTTGGTGGAACAAATAATCAAAATGCAATTTTTCTAAACGCCTTAAATCTAAGGGGTTATTAATATCA
GCTGCAATCACCTCACCCTTAAAACCGATTAAATTCTTAAAATGCCCTAAAGAACTGGGGCGCTTATTAC
TGAAAAGCGTGTTACTGCGGAATTTATCTAAAATGATTACTTTAGCTTTAGGGTGGTTCTCTTGAAAATA
AAAGGCTAGATTACTGCCTACAAAGCCAGCCCCACCGGTGATTAAAATCGTTTGATTTTCTAATTCATCA
TCAATATAACGCA
Protein Sequence 
>gi|15645478|ref|NP_207653.1| ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) [Helicobacter pylori 26695]
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLGHFKNLIGFKG
EVIAADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAG
VYGNTKAPNVVGSNESPENVYGFSKLCMDEFVLSHSNDNVQVGLRYFNVYGPREFYKEKTASMVLQLALG
AMAFKEVKLFEFGEQLRDFVYIEDVIQASVKAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYI
KNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIKDYLPHIHAIFKGQCA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: HP0859 knockout mutant exhibited a severe truncation of LPS, a decreased growth rate, and a higher susceptibility to novobiocin. Disruption of HP0859 also reduced the adhesive capacity of H. pylori to AGS cells (Chang et al., 2011).
COG COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism
References
Chang et al., 2011: Chang PC, Wang CJ, You CK, Kao MC. Effects of a HP0859 (rfaD) knockout mutation on lipopolysaccharide structure of Helicobacter pylori 26695 and the bacterial adhesion on AGS cells. Biochemical and biophysical research communications. 2011; ; . [PubMed: 21256827].