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cagE

Victor ID 3389
Gene Name cagE
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 7010926
NCBI Protein GI 210134746
Locus Tag HPP12_0551
Protein Accession YP_002301185.1
Other Database IDs UniProtKB-ID: B6JLC7_HELP2
UniRef100: UniRef100_B6JLC7
UniRef90: UniRef90_Q9ZLT4
UniRef50: UniRef50_Q9ZLT4
UniParc: UPI00018335A4
EMBL: CP001217
EMBL-CDS: ACJ07705.1
RefSeq_NT: NC_011498.1
GenomeReviews: CP001217_GR
KEGG: hpp:HPP12_0551
HOGENOM: HBG501743
ProtClustDB: CLSK477502
Taxonomy ID 570508
Gene Starting Position 580844
Gene Ending Position 583795
Gene Strand (Orientation) -
Protein Name cag pathogenicity island protein E VirB4-like protein
DNA Sequence 
>gi|210134201:580844-583795 Helicobacter pylori P12 chromosome, complete genome
TTTAATACTCCTTTATTTGTTGATACATTTGCCTCAAGGCCTGATATTTATCTATGATACTATGGTTTTG
GATAATCTTGTCAATTTCTTTGACAAATACAGTATCTGTGGATAAAATTTTCAAATATTCTTTAGGAATG
CCTCTCAAATTAAAACTAGCGATAACGCTAGGGCTTCCATCTTGTTTGTAGAGAATTTTCCTATCTAGCC
CCTTAGTGATGATTTCAAATTCTTTTTCTGTAACATTGGCTAATCTTTGGTAATCAGAAAGATTGCCCCC
ATCGTTTCTCAAAAAAATCTTTGTAGGGCATTGTTCTCTAATCGTATCAGCAATAGGGCAAGCCAAAAGA
TCAGTGATGCTTTGAGTCGCAAGTCTGACAATAGCGTTTCTTTTCCTTGCAGTTTTTAGCATGTCTCTCA
CAAAATAAGCGACCTTTGGATCGCCTAAATATTTCCAAGCTTCATCAATATCTAAGACAAATCTACGCCC
ATCCATTGCCTCTTGGATACGAGCGAAAAGGTAAAAACAAATAAAGGGCGAAACATCATTATTGTCTAAG
AAACTTGACCCATCAACGCCAATAATCGTTTTTGAAAAATCTAAGCGATCCGTTGCTTTATTGTCAAAAA
GCCATTGAAATTCACCATTGGTTGATTTGCAAAAAGGCGCTAATCGCGCGACAAGCCCATTAGGATCGTT
GTGGTCTTTTCCGAAAGCATTAATAAGTTGAGTGATAGGATAATCTAGGTTCATATCTCCTGTGATAAGA
TTGGTTACTGCCGCTGCAAGCGTGTTAGAATCTGCTAGGCTAAAAGAGATGCTGTTGCCATTTTCATCTT
TTTCATCGCTTTTGGTTGCTAAGTTTTTCACAAGCTCTTTGACAACAGAAATAGCTGTTTGTTTTTGCTC
CATTGTTGCATTTGTTTTTTGCACACAAGCCGCCCAAGCAAAAGGATTTAATCCTGTATCTGTCCCTAGC
TCAATCTTGACATACTCCCCACCCATTGCGACAATATTCCCATAAGCGCCATAATCTTTATCCATATAAA
CCATAGTGAGCTTTTGCTTGTCTTTGCTGACATTAGCAGGAAAATTGTGAACAAATTGTCCCATAGCGTT
CAAAGTCATTGACATAAACACTGTCTTACCTGAACCGGTTGAGCCAAGTATCAAAGTGTGTCCTGCTGAA
GCTGAACCAAAATCAGTAGGCATGTGGAAATTCAGATAAAAAGGCGAATTGATTTCGCTTTTTAGCGTCA
TCACACTATTGCCCCAAGCGTTATTCTCTTGATTGCCATCAAAACTCATAGCCCTCATAGCAATGAAATC
AGCAAAATTATTAGAAGTTACATCAAAAATAAAAGGAAGCGTGATAAAAGAGCAATGTTTGGCAAAAAAG
TAATTTTCCATAGAGAAAGTCGCTGCGTTGGCTAAAAAACCTTTAGCGTTAAGACTAGAGACGCATTCCT
TAACGCTTTGTTTCATTTTTTCAAAGCTATCAGCAAACAGCACTAAAGAATTACCATAACTGCCTAGCGT
AATATCACCATTACCCACTAATTCGCTCAAGCAACCTAAAGTCATGCCCTGCTCTTTAGAGCCTCCACTA
ATAATAATTCTTCTAGAGGTGAAAGCCAGTTTGTCCTTTAAAACCTGTGAGTTTTTAGGCGAATAAGCAT
GCATGAAAATAAATTCGCTGTCTAGAGCGTTGATTTTATCAAACAAATCGCTCTGTGATTTAGGGGCGTA
TTCGCTGATCTCAATAGCGCTAAAATATTTTTCACTCAAATCGTCATTTAAGATTTTTCCATGCTTATTA
GCAAAATAAACTTCTTTCACCCCACCATGCATTTTTTCCTTGAGATACAAGTCTTTTCTGTTGCAAATAA
AAGGGGCTTCATTCATTCCCACCAAAAAATTGTAAAACTCGCATTGTTTGGAGTAAATAATGCCATCTTT
GGTGTATTCTTTCAATCTAGTGGGGTGGTATTTACTCAGTAGCTCTTCTATAAGCTCTATCCTATCCTTG
AAGTTTTCAAGCTTGGCTCTAATAATCCTTTGAAACTCTTCAAAATTATTGTCTGCAAAATGCTTTTTAT
TCATAACGGGTTCATTGAGAGTGTCTAATAAATCTTGCTCTATGGTGAGATAAAAACTAATATCATAAAA
ACTTTCTCTCTTTTGCTTCTCATTATAGGCTCGCATGAAATCATTAGAAAAAATAAGACCATAGTCCCTA
TTGGTTTCATCAATAACGATTTTCTTTTTAATAGTGTGAAAATAAAATTTGAATTCAGGGGTAACAAAAT
TCCTAAAAACGCTATAAATAGAAGCGTGTAACTCTATGAGATCTTTTTTGGAAGTGGTTAAAAAATCAAT
GCCCCCCAATTTGATTGTGCCTAAAAGAGAATAGTTGTTAGTAAGGATCACCCCATCATCTAAAAAACAT
TCATAGTTATTCGCTAGATAGGAGTTTGCAGCGCTCACAAGTCTGTCTTCTCTGTTTGGATTTAAGTGGA
TGTCATTAGCCATTTCTTTACTAGGTTTCATGGAAAAAATGCTCATGAATGCCTTGTTTTTCACGCCCTT
AAACAAAAAAGGTTTTTTAAATTTCATCGCTCGCTCCATTCTTTGATAAAGCCTATAATCTTTCTTGAAT
CCAAGAGCTACAAGCACAATAACAATCGCTACAATCAAAACAGGTTCATAGGCTTGAAAAAGAATAACAG
ATAATACAATTGTTACAAACAATATAAATATAGAGGAATAAATAAAAGTTTCAGGGAAACCAAACAACCT
ATTCCCCCCATCAAACAAGACTTTAAAAAAAGGATTGACACCTTTTTGCATGTCTGCTTTAAGTTCTTCT
ATTTTTTGAAATTGGCGCTTTTGAACCTCTTGCTCTATGATTAGCTTTTTTTGTTCGTCAGCTTGTTTGC
TTGCCACAAACA
Protein Sequence 
>gi|210134746|ref|YP_002301185.1| cag pathogenicity island protein E VirB4-like protein [Helicobacter pylori P12] MFVASKQADEQKKLIIEQEVQKRQFQKIEELKADMQKGVNPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQAYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAANSYLANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRDYGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLSKYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEISEYAPKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSLVLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFAKHCSFITLPFIFDVTSNNFADFIAMRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFVHNFPANVSKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEKDENGNSISFSLADSNTLAAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLDFSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQSITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLKILSTDTVFVKEIDKIIQNHSIIDKYQALRQMYQQIKEY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils (Ogura et al., 2000).
COG COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Ogura et al., 2000: Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, Yoshida H, Shiratori Y, Omata M. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. The Journal of experimental medicine. 2000; 192(11); 1601-1610. [PubMed: 11104802].