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vacA

Victor ID 401
Gene Name vacA
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 890075
NCBI Protein GI 15611886
Locus Tag jhp0819
Protein Accession NP_223537.1
Other Database IDs UniProtKB-ID: VACA_HELPJ
UniRef100: UniRef100_Q9ZKW5
UniRef90: UniRef90_Q9ZKW5
UniRef50: UniRef50_Q9ZKW5
UniParc: UPI00001380B7
EMBL: AE001439
EMBL-CDS: AAD06400.1
RefSeq_NT: NC_000921.1
GenomeReviews: AE001439_GR
KEGG: hpj:jhp0819
NMPDR: fig|85963.1.peg.815
HOGENOM: HBG501852
OMA: FANQHEF
ProtClustDB: CLSK477705
BioCyc: HPYL85963:JHP0819-MONOMER
Taxonomy ID 85963
Gene Starting Position 900010
Gene Ending Position 903876
Gene Strand (Orientation) +
Protein Name vacuolating cytotoxin
DNA Sequence 
>gi|15611071:900010-903876 Helicobacter pylori J99, complete genome
AATGGAAATACAACAAACACACCGCAAAATCAATCGCCCTTTAGTTTCTCTCGTTTTAGCAGGAGCGTTG
ATTAGCGCCATACCGCAAGAGAGTCATGCCGCCTTTTTCACGACCGTGATCATTCCAGCCATTGTTGGGG
GTATCGCCACAGGCACTGCTGTAGGAACGGTCTCAGGGCTTCTTAGTTGGGGACTCAAACAAGCCGAAGA
AGCGAATAAAACCCCAGATAAACCCGATAAAGTTTGGCGCATTCAAGCAGGAAAAGGCTTTAATGAATTT
CCTAACAAGGAATACGACTTATACAAATCCCTTTTATCCAGTAAGATTGATGGAGGTTGGGACTGGGGGA
ACGCCGCTAGGCATTATTGGGTCAAAGGCGGGCAATGGAACAAGCTTGAAGTGGATATGAAAGACGCTGT
AGGGACTTATAAACTATCAGGGCTTAGAAACTTTACTGGTGGGGATTTAGACGTGAATATGCAAAAAGCC
ACTTTGCGTTTGGGCCAATTCAATGGCAATTCTTTCACAAGCTATAAGGATAGCGCTGATCGCACCACGA
GAGTGAATTTCAACGCTAAAAATATTTCAATTGATAATTTTGTAGAAATCAATAATCGTGTGGGTTCTGG
AGCCGGGAGAAAAGCCAGCTCTACGGTTTTGACTTTGCAAGCTTCAGAAGGGATCACTAGCAGTAAAAAT
GCGGAAATTTCTCTTTATGATGGCGCCACGCTCAATTTGGCTTCAAACAGCGTTAAATTAAATGGTAATG
TGTGGATGGGCCGTTTGCAATACGTGGGAGCGTATTTAGCCCCTTCATACAGCACGATCAACACTTCAAA
AGTTCAAGGGGAAGTGGATTTTAACCATCTCACTGTGGGGGATCAAAACGCCGCTCAAGCGGGCATTATC
GCTAGCAATAAGACTCATATTGGCACACTGGATTTGTGGCAAAGCGCCGGGTTAAATATCATTGCCCCTC
CAGAAGGTGGCTACAAGGATAAACCTAATAGTACCACTTCTCAAAGTGGCACTAAAAACGACAAGAAAGA
GATCAGTCAAAATAACAATAGCAACACAGAGGTCATTAACCCACCCAATAACACGCAAAAAACAGAAACT
GAACCCACGCAAGTCATTGATGGGCCTTTTGCTGGCGGCAAAGACACGGTTGTCAATATTTTCCACTTAA
ACACTAAAGCCGATGGCACGATTAAAGTGGGAGGGTTTAAAGCTTCTCTTACCACGAATGCGGCTCATTT
GAATATCGGCAAAGGCGGTGTCAATCTGTCCAATCAAGCGAGCGGGCGCACCCTTTTAGTGGAAAATCTA
ACCGGGAATATCACCGTTGATGGGCCTTTAAGAGTGAATAATCAAGTGGGTGGCTATGCTTTGGCAGGAT
CAAGCGCGAATTTTGAGTTTAAGGCTGGTGTGGATACTAAAAACGGCACAGCCACTTTCAATAACGATAT
TAGTTTGGGAAGATTTGTGAATTTAAAGGTGGATGCTCATACAGCTAATTTTAAAGGTATTGATACGGGT
AATGGTGGTTTCAACACCTTAGATTTTAGTGGTGTTACAGACAAAGTCAATATCAACAAGCTCATCACAG
CTTCCACTAATGTGGCCGTTAAAAACTTCAACATTAATGAATTGATTGTTAAAACCAATGGGATAAGTGT
GGGGGAATACACTCATTTTAGCGAAGATATAGGCAGTCAATCGCGTATCAATACCGTGCGTTTGGAAACT
GGCACTAGGTCAATCTTTTCTGGGGGTGTCAAATTTAAAAGCGGTGAAAAACTAGTTATCAATGATTTTT
ACTATAGCCCTTGGAATTATTTTGACGCTAGGAATGTTAAAAATGTTGAAATCACCAGAAAATTCGCTTC
TTCAACCCCAGAAAACCCTTGGGGCACATCAAAGCTCATGTTTAATAATCTAACCTTGGGTCAAAATGCG
GTCATGGACTATAGTCAATTTTCAAATTTAACCATTCAGGGGGATTTTATCAACAATCAAGGCACTATCA
ACTATCTGGTCCGAGGCGGGAAAGTGGCAACCTTAAATGTAGGCAATGCAGCAGCTATGATGTTTAATAA
TGATATAGACAGCGCGACCGGATTTTACAAACCGCTCATCAAGATTAACAGCGCTCAAGATCTCATTAAA
AATACAGAGCATGTTTTATTGAAAGCGAAAATCATTGGTTATGGTAATGTTTCTACAGGTACCAATGGCA
TTAGTAATGTTAATCTAGAAGAGCAATTCAAAGAGCGCCTAGCCCTTTATAACAATAATAACCGCATGGA
TACTTGTGTGGTGCGAAATACTGATGACATTAAAGCATGCGGTATGGCTATCGGCAATCAAAGCATGGTG
AACAACCCTGACAATTACAAGTATCTTATCGGTAAGGCATGGAGAAATATAGGCATCAGTAAAACGGCTA
ACGGCTCTAAAATTTCGGTGTATTATTTAGGCAATTCTACGCCTACTGAGAATGGTGGCAATACCACCAA
CTTACCCACAAACACCACTAATAATGCGCATTCTGCTAACTACGCTCTCGTGAAGAACGCTCCTTTCGCT
CACAGCGCCACTCCTAATTTAGTCGCTATCAATCAGCATGATTTTGGCACTATTGAGAGCGTGTTTGAAT
TGGCTAACCGCTCTAAAGATATTGACACGCTCTATACTCATTCAGGCGCGCAAGGCAGGGATCTCTTGCA
AACTTTATTGATTGATAGCCATGATGCGGGTTATGCCAGACAAATGATTGATAACACAAGCACCGGTGAA
ATCACCAAGCAATTGAATGCGGCCACTGACGCTTTAAACAACGTAGCCAGTTTAGAGCATAAACAAAGCG
GCTTACAAACCTTGAGCTTGAGTAATGCGATGATTTTAAATTCTCGTTTAGTCAATCTCTCTAGGAAGCA
CACCAACCATATTAACTCGTTCGCTCAACGCTTACAAGCTTTAAAAGGCCAAGAATTCGCTTCTTTAGAG
AGCGCGGCAGAAGTGTTGTATCAATTTGCCCCTAAATATGAAAAACCTACCAATGTTTGGGCTAACGCTA
TTGGGGGAGCGAGCTTGAATAGCGGCTCTAACGCTTCATTGTATGGCACAAGCGCCGGCGTAGACGCTTT
CCTTAACGGGAATGTGGAAGCCATTGTGGGCGGTTTTGGAAGCTATGGTTATAGCTCCTTTAGCAATCAA
GCGAACTCTCTTAACTCTGGGGCCAATAACGCTAATTTTGGCGTGTATAGCCGTTTTTTTGCCAACCAGC
ATGAATTTGACTTTGAAGCTCAAGGGGCGCTAGGGAGCGATCAATCAAGCTTGAATTTCAAAAGCACTCT
ATTACAAGATTTGAATCAAAGCTATAATTACTTAGCCTATAGCGCCACAGCAAGAGCGAGTTATGGTTAT
GACTTCGCGTTTTTTAGGAACGCTTTAGTGTTAAAACCAAGCGTGGGCGTGAGCTATAACCATTTAGGTT
CAACCAACTTTAAAAGCAATAGCCAATCACAAGTGGCTTTAAAAAATGGCGCGAGCAGTCAGCATTTATT
CAACGCTAACGCTAACGTGGAAGCGCGTTATTATTATGGGGACACTTCATACTTTTATTTGCATGCGGGA
GTTTTACAAGAGTTCGCTCACTTTGGATCGAATGATGTGGCGTCTTTAAACACCTTTAAAATCAATGCCG
CTCGCAGTCCTTTAAGCACCTATGCAAGAGCGATGATGGGTGGGGAATTGCAATTGGCTAAAGAAGTGTT
TTTGAATTTGGGCGTGGTTTATTTGCACAATTTGATTTCCAACGCAAGCCATTTCGCTTCCAATTTAGGA
ATGAGGTATAGTTTCTA
Protein Sequence 
>gi|15611886|ref|NP_223537.1| vacuolating cytotoxin [Helicobacter pylori J99] MEIQQTHRKINRPLVSLVLAGALISAIPQESHAAFFTTVIIPAIVGGIATGTAVGTVSGLLSWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYKSLLSSKIDGGWDWGNAARHYWVKGGQWNKLEVDMKDAVGTYKLSGLRNFTGGDLDVNMQKATLRLGQFNGNSFTSYKDSADRTTRVNFNAKNISIDNFVEINNRVGSGAGRKASSTVLTLQASEGITSSKNAEISLYDGATLNLASNSVKLNGNVWMGRLQYVGAYLAPSYSTINTSKVQGEVDFNHLTVGDQNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNSTTSQSGTKNDKKEISQNNNSNTEVINPPNNTQKTETEPTQVIDGPFAGGKDTVVNIFHLNTKADGTIKVGGFKASLTTNAAHLNIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVGGYALAGSSANFEFKAGVDTKNGTATFNNDISLGRFVNLKVDAHTANFKGIDTGNGGFNTLDFSGVTDKVNINKLITASTNVAVKNFNINELIVKTNGISVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVINDFYYSPWNYFDARNVKNVEITRKFASSTPENPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGTINYLVRGGKVATLNVGNAAAMMFNNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKIIGYGNVSTGTNGISNVNLEEQFKERLALYNNNNRMDTCVVRNTDDIKACGMAIGNQSMVNNPDNYKYLIGKAWRNIGISKTANGSKISVYYLGNSTPTENGGNTTNLPTNTTNNAHSANYALVKNAPFAHSATPNLVAINQHDFGTIESVFELANRSKDIDTLYTHSGAQGRDLLQTLLIDSHDAGYARQMIDNTSTGEITKQLNAATDALNNVASLEHKQSGLQTLSLSNAMILNSRLVNLSRKHTNHINSFAQRLQALKGQEFASLESAAEVLYQFAPKYEKPTNVWANAIGGASLNSGSNASLYGTSAGVDAFLNGNVEAIVGGFGSYGYSSFSNQANSLNSGANNANFGVYSRFFANQHEFDFEAQGALGSDQSSLNFKSTLLQDLNQSYNYLAYSATARASYGYDFAFFRNALVLKPSVGVSYNHLGSTNFKSNSQSQVALKNGASSQHLFNANANVEARYYYGDTSYFYLHAGVLQEFAHFGSNDVASLNTFKINAARSPLSTYARAMMGGELQLAKEVFLNLGVVYLHNLISNASHFASNLGMRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: knockout did not result in gastric ulcers in mice compared to wild type (Isomoto et al., 2010).
References
Isomoto et al., 2010: Isomoto H, Moss J, Hirayama T. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. The Tohoku journal of experimental medicine. 2010; 220(1); 3-14. [PubMed: 20046046].