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|
LPS |
| Victor ID |
4870 |
|
Gene Name |
LPS |
|
Sequence Strain (Species/Organism) |
Helicobacter pylori |
|
Gene Strand (Orientation) |
? |
|
Molecule Role |
Virulence factor |
|
Molecule Role Annotation |
MUTATION: Insertional inactivation of HP0479 resulted in formation of a truncated LPS molecule lacking an alpha-1,6-glucan-, dd-heptose-containing outer core region and O-chain polysaccharide. Introduction of the HP0479 mutation into the H. pylori mouse-colonizing Sydney (SS1) strain and the clinical isolate PJ1, which expresses dd-heptoglycan, resulted in the loss of colonization in a mouse model (Hiratsuka et al., 2005). |
| References |
Hiratsuka et al., 2005: Hiratsuka K, Logan SM, Conlan JW, Chandan V, Aubry A, Smirnova N, Ulrichsen H, Chan KH, Griffith DW, Harrison BA, Li J, Altman E. Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori. Journal of bacteriology. 2005; 187(15); 5156-5165. [PubMed: 16030209].
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