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vacA

Victor ID 3399
Gene Name vacA
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 6963731
NCBI Protein GI 208434795
Locus Tag HPG27_840
Protein Accession YP_002266461.1
Other Database IDs UniProtKB-ID: B5Z7P6_HELPG
UniRef100: UniRef100_B5Z7P6
UniRef90: UniRef90_Q48247
UniRef50: UniRef50_Q9ZKW5
UniParc: UPI000181C405
EMBL: CP001173
EMBL-CDS: ACI27595.1
RefSeq_NT: NC_011333.1
GenomeReviews: CP001173_GR
KEGG: hpg:HPG27_840
HOGENOM: HBG501852
OMA: YSTINTS
ProtClustDB: CLSK477705
Taxonomy ID 563041
Gene Starting Position 906392
Gene Ending Position 910276
Gene Strand (Orientation) +
Protein Name vacuolating cytotoxin A
DNA Sequence 
>gi|208433976:906392-910276 Helicobacter pylori G27, complete genome
AATGGAAATACAACAAACACACCGCAAAATGAATCGCCCTTTAGTTTCTCTCGTTTTAGCAGGAGCGTTA
ATTAGCGCCATACCGCAAGAAAGTCATGCCGCCTTTTTCACGACCGTGATCATTCCAGCCATTGTTGGGG
GTATCGCCACAGGCACCGCTGTAGGAACGGTCTCAGGGCTTCTTAGCTGGGGGCTCAAACAAGCCGAAGA
AGCGAATAAAAACCCGGACAAACCCGATAAAGTTTGGCGCATTCAAGCAGGAAAAGGCTTTAATGAATTC
CCTAACAAGGAATACGACTTATACAAATCCCTTTTATCCAGTAAGATTGATGGAGGTTGGGACTGGGGGA
ACGCCGCTAGGCATTATTGGGTCAAAGGCGGGCAATGGAACAAGCTTGAAGTGGATATGAAAGACGCTGT
AGGGACTTATAAACTATCAGGGCTTAGAAACTTTACTGGTGGGGATTTAGATGTCAATATGCAAAAAGCC
ACTTTACGCTTGGGCCAATTCAATGGCAATTCTTTCACAAGCTATAAGGATGCGGCTGATCGCACCACGA
GGGTGAATTTCAACGCTAAAAATATCTCAATTGATAATTTTGTAGAAATCAATAATCGTGTGGGTTCTGG
AGCCGGGAGGAAAGCCAGCTCTACGGTTTTGACTTTGCAAGCTTCAGAAGGGATCACTAGCGATAAAAAC
GCTGAAATTTCTCTTTATGATGGCGCCACGCTCAATTTGGCTTCAAGCAGCGTTAAATTAATGGGTAATG
TGTGGATGGGCCGTTTGCAATACGTGGGAGCGTATTTGGCCCCTTCATACAGCACGATAAACACTTCAAA
AGTAACAGGGGAAGTGAATTTTAACCACCTCACTGTTGGCGATAAAAACGCCGCTCAAGCGGGCATTATC
GCTAGCAACAAGACTCATATTGGCACACTGGATTTGTGGCAAAGCGCCGGGTTAAACATTATCGCTCCTC
CCGAAGGTGGCTATAAGGATAAACCTAATAATACCCCTTCTCAAAGTGGCACTAAAAACGACAAAAATGA
AAGCGCTAAAAACGACAAACAAGAGAGCAGTCAAAATAATAGTAACACTCAGGTCATTAACCCACCCAAT
AGCACGCAAAAAACAGAAATTCAACCCACGCAAGTCATTGATGGGCCTTTTGCGGGCGGCAAAGACACGG
TTGTCAATATCAACCGCATCAACACTAACGCTGATGGCACGATTAGAGTGGGAGGGTTTAAAGCTTCTCT
TACCACCAATGCGGCTCATTTGCATATCGGCAAAGGCGGTGTCAATCTGTCCAATCAAGCGAGCGGGCGC
ACCCTTTTAGTGGAAAATCTAACCGGGAATATCACCGTTGATGGGCCTTTAAGAGTGAATAATCAAGTGG
GTGGCTATGCTTTGGCAGGATCAAGCGCGAATTTTGAATTTAAGGCTGGTGTGGATACTAAAAACGGCAC
AGCCACTTTCAATAACGATATTAGCCTGGGAAGATTTGTGAATTTAAAGGTGGATGCTCATACAGCTAAT
TTTAAAGGTATTGATACGGGTAATGGTGGTTTCAACACCTTAGATTTTAGTGGTGTTACAGACAAAGTCA
ATATCAACAAGCTCATCACGGCTTCCACTAATGTGGCCGTTAAAAACTTCAACATTAATGAATTGATTGT
TAAAACCAATGGGATAAGTGTGGGGGAATACACTCATTTTAGCGAAGATATAGGCAGTCAATCGCGCATC
AATACCGTGCGTTTGGAAACTGGCACTAGGTCAATCTTTTCTGGGGGTGTCAAATTTAAAAGCGGCGAAA
AATTGGTTATAGATGAGTTTTACTATAGCCCTTGGAATTATTTTGACGCTAGGAATGTTAAAAATGTTGA
AATCACCAGAAAATTCGCTTCTTCAACCCCAGAAAACCCTTGGGGCACATCAAAACTTATGTTTAATAAT
CTAACCCTGGGTCAAAATGCGGTCATGGACTATAGTCAATTTTCAAATTTAACCATCCAAGGGGATTTTA
TCAACAATCAAGGCACTATCAACTATCTGGTCCGAGGCGGGAAAGTGGCAACCTTAAGCGTAGGCAATGC
AGCAGCTATGATGTTTAATAATGATATAGACAGCGCGACCGGATTTTACAAACCGCTCATCAAGATTAAC
AGTGCTCAAGATCTCATTAAAAATACAGAGCATGTTTTATTGAAAGCGAAAATCATTGGTTATGGTAATG
TTTCTACAGGTACCAATAGCATTAGTAATGTTAATCTAGAAGAGCAATTCAAAGAGCGCCTAGCCCTTTA
TAACAACAATAACCGCATGGATACTTGTGTGGTGCGAAATACTGATGACATTAAAGCATGCGGTATGGCT
ATCGGCAATCAAAGCATGGTGAATAACCCTGACAATTACAAGTATCTTATCGGTAAGGCATGGAAAAATA
TAGGCATCAGTAAAACGGCTAACGGCTCTAAAATTTCGGTGTATTATTTAGGCAATTCTACGCCTACTGA
GAATGGTGGCAATACCACCAACTTACCCACCAACACCACTAATAATGCGCGTTCTGCTAACTACGCCCTC
GTGAAGAACGCTCCTTTCGCTCACAGTGCCACTCCTAATTTAGTCGCTATCAATCAGCATGATTTTGGCA
CTATTGAAAGCGTGTTTGAATTGGCTAACCGCTCTAAAGATATTGACACGCTTTATACTCATTCAGGCGT
GCAAGGTAGGGATCTCTTACAAACCTTATTGATTGATAGCCATGATGCGGGTTATGCCAGACAAATGATT
GATAACACAAGCACCGGTGAAATCACCAAACAATTGAATGCGGCCACTGACGCTTTAAACAACATAGCCA
GTTTAGAGCATAAAACCAGCGGCTTGCAAACTTTGAGCTTGAGTAATGCGATGATTTTAAATTCTCGTTT
AGTCAATCTCTCCAGGAAGCACACCAACCATATTGACTCGTTCGCTCAACGCTTACAAGCTTTAAAAGGC
CAAAGATTCGCTTCTTTAGAGAGCGCGGCAGAAGTGTTGTATCAATTTGCCCCTAAATATGAAAAACCTA
CCAATGTTTGGGCTAACGCTATTGGGGGAGCGAGCTTGAATAATGGCGGCAACGCTTCATTGTATGGCAC
AAGTGCCGGTGTAGACGCTTACCTTAATGGGGAAGTGGAAGCCATTGTGGGCGGGTTTGGAAGCTATGGT
TATAGCTCTTTTAGTAATCGTGCGAACTCTCTTAACTCTGGGGCTAATAACGCTAATTTTGGCGTGTATA
GCCGTATTTTTGCTAACCAGCATGAATTTGATTTTGAAGCTCAAGGGGCGCTAGGGAGTGATCAATCAAG
CTTGAATTTCAAAAGTGCTCTACTGCAAGATTTGAATCAAAGCTATCATTATTTAGCCTATAGCGCTGCA
ACAAGAGCGAGCTATGGTTATGACTTTGCGTTTTTCAGGAACGCTTTAGTGTTAAAACCAAGCGTGGGCG
TGAGCTATAACCATTTAGGTTCAACCAACTTTAAAAGCAGCAGCAATCAAGTGGCTTTGAAAAATGGCTC
TAGCAGTCAGCATCTATTCAACGCTAACGCTAATGTGGAAGCGCGCTATTATTATGGGGACACTTCATAC
TTCTATATGAACGCTGGAGTTTTACAAGAGTTCGCTCGCTTTGGATCTAATAACGCCGCGTCTTTAAACA
CCTTTAAAGTGAATACCGCTCGCAACCCTTTAAATACCCATGCCAGAGTGATGATGGGTGGGGAATTGCA
ATTAGCTAAAGAAGTGTTTTTGAATTTGGGCGTTGTTTATTTGCACAATTTGATTTCCAATATAGGCCAT
TTCGCTTCCAATTTAGGAATGAGGTATAGTTTCTA
Protein Sequence 
>gi|208434795|ref|YP_002266461.1| vacuolating cytotoxin A [Helicobacter pylori G27] MEIQQTHRKMNRPLVSLVLAGALISAIPQESHAAFFTTVIIPAIVGGIATGTAVGTVSGLLSWGLKQAEEANKNPDKPDKVWRIQAGKGFNEFPNKEYDLYKSLLSSKIDGGWDWGNAARHYWVKGGQWNKLEVDMKDAVGTYKLSGLRNFTGGDLDVNMQKATLRLGQFNGNSFTSYKDAADRTTRVNFNAKNISIDNFVEINNRVGSGAGRKASSTVLTLQASEGITSDKNAEISLYDGATLNLASSSVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFNHLTVGDKNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNNTPSQSGTKNDKNESAKNDKQESSQNNSNTQVINPPNSTQKTEIQPTQVIDGPFAGGKDTVVNINRINTNADGTIRVGGFKASLTTNAAHLHIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVGGYALAGSSANFEFKAGVDTKNGTATFNNDISLGRFVNLKVDAHTANFKGIDTGNGGFNTLDFSGVTDKVNINKLITASTNVAVKNFNINELIVKTNGISVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVIDEFYYSPWNYFDARNVKNVEITRKFASSTPENPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGTINYLVRGGKVATLSVGNAAAMMFNNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKIIGYGNVSTGTNSISNVNLEEQFKERLALYNNNNRMDTCVVRNTDDIKACGMAIGNQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVYYLGNSTPTENGGNTTNLPTNTTNNARSANYALVKNAPFAHSATPNLVAINQHDFGTIESVFELANRSKDIDTLYTHSGVQGRDLLQTLLIDSHDAGYARQMIDNTSTGEITKQLNAATDALNNIASLEHKTSGLQTLSLSNAMILNSRLVNLSRKHTNHIDSFAQRLQALKGQRFASLESAAEVLYQFAPKYEKPTNVWANAIGGASLNNGGNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNRANSLNSGANNANFGVYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLQDLNQSYHYLAYSAATRASYGYDFAFFRNALVLKPSVGVSYNHLGSTNFKSSSNQVALKNGSSSQHLFNANANVEARYYYGDTSYFYMNAGVLQEFARFGSNNAASLNTFKVNTARNPLNTHARVMMGGELQLAKEVFLNLGVVYLHNLISNIGHFASNLGMRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: knockout did not cause gastric ulcers in mice compared to wild type (Isomoto et al., 2010).
References
Isomoto et al., 2010: Isomoto H, Moss J, Hirayama T. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. The Tohoku journal of experimental medicine. 2010; 220(1); 3-14. [PubMed: 20046046].