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cagE

Victor ID 3395
Gene Name cagE
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 6963392
NCBI Protein GI 208434465
Locus Tag HPG27_503
Protein Accession YP_002266131.1
Other Database IDs UniProtKB-ID: B5Z6R6_HELPG
UniRef100: UniRef100_B5Z6R6
UniRef90: UniRef90_Q9ZLT4
UniRef50: UniRef50_Q9ZLT4
UniParc: UPI000181C31E
EMBL: CP001173
EMBL-CDS: ACI27265.1
RefSeq_NT: NC_011333.1
GenomeReviews: CP001173_GR
KEGG: hpg:HPG27_503
HOGENOM: HBG501743
OMA: KSAISDT
ProtClustDB: CLSK477502
Taxonomy ID 563041
Gene Starting Position 543531
Gene Ending Position 546482
Gene Strand (Orientation) -
Protein Name cag pathogenicity island protein E
DNA Sequence 
>gi|208433976:543531-546482 Helicobacter pylori G27, complete genome
TTTAATACTCCTCTATTTGTTGATACATTTGTCTCAAGGCCTGATATTTATCTATGATACTATGGTTTTG
GATAATCTTGTCAATTTCTTTGACAAATACAGTATCTGTGGATAAAATTTTCAAATATTCTTTAGGAATG
CCTCTCAAATTAAAACTAGCGATAACGCTAGGGCTTCCATCTTGTTTGTAGAGAATTTTCCTGTCTAGTC
CCTTAGTGATGATTTCAAATTCTTTTTCTGTAACATTAGCCAATCTTTGGTAATCAGAAAGATTGCCCCC
ATCGTTTCTCAAAAAAATCTTTGTAGGGCATTGTTCTCTAATCGTATCAGCAATAGGGCAAGCCAAAAGA
TCAGTGATGCTTTGAGTCGCAAGTCTGACAATAGCGTTTCTTTTCCTTGCAGTTTTTAGCATGTCTCTTA
CAAAATAAGCGACCTTTGGATCGCCTAAATATTTCCACGCTTCATCAATATCTAAGACAAATCTACGCCC
ATCCATTGCCTCTTGGATACGAGCGAAAAGGTAAAAACAAATAAAGGGTGAAACATCATTATTGTCTAAG
AAACTTGACCCATCAACGCCAATAATCGTTTTTGAAAAATCTAAGCGATCTGTTGCTTTATTGTCAAAAA
GCCATTGAAATTCACCATTGGTTGATTTGCAAAAAGGCGCTAATCGCGCGACAAGCCCATTAGGATCATT
GTGGTCTTTCCCGAAAGCATTAATAAGTTGAGTGATAGGATAATCTAGGTTCATATCTCCTGTGATAAGG
TTGGTTACTGCCGCTGCAAGCGTGTTAGAATCTGCTAGGCTAAAAGAGATGCTGTTGCCATTTTCATCTT
TTTCATCGCTTTTGGTCGCTAGGTTTTTCACAAGCTCTTTGACAACAGAAATAGCTGTTTGTTTTTGCTC
CATTGTTGCATTTGTTTTTTGCACACAAGCCGCCCAAGCAAAAGGATTTAATCCTGTATCTGTCCCTAGC
TCAATCTTGACATACTCCCCACCCATTGCGACAATATTCCCATAAGCGCCATAATCTTTATCCATATAGA
CCATAGTGAGCTTTTGCTTGTCTTTGCTGACATTAGCAGGAAAATTATAGGCAAATTGTCCCATAGCGTT
TAGAGTCATGGACATAAACACTGTCTTACCTGAACCGGTTGAGCCAAGTATCAAAGTGTGTCCTGCTGAA
GCTGAACCAAAATCAGTAGGCATGTGGAAGTTCAAATAAAAAGGCGAATTGATCTCGCTTTTTAGCGTCA
TCACGCTATTACCCCAAGCGTTATTGTCTTGATTGCCATCAAAACTCATCGCTCTCATCGCAATGAAATC
AGCAAAATTATTAGAAGTTACATCAAAAATAAAAGGAAGCGTGATAAAAGAGCAATGTTTGGCAAAAAAG
TAATTTTCCATAGAGAAAGTCGCTGCGTTGGCTAAAAAACCTTTAGCGTTAAGACTAGAGACGCATTCCT
TAACGCTTTGTTTCATTTTTTCAAAGCTATCAGCAAACAGCACTAAAGAATTACCATAACTGCCTAGCGT
AATATCACCATTACCCACTAATTCGCTCAAGCAACCTAAAGTCATGCCCTGCTCTTTAGAGCCTCCACTA
ATAATAATTCTTCTAGAGGTGAAAGCCAGTTTGTCCTTTAAAACTTGTGAGTTTTTAGGTGAATAAGCAT
GCATAAAGATAAATTCGCTGTCTAGAGCGTTGATTTTATCAAACAAATCGCTCTGTGATTTAGGAGCGTA
TTCACTGATCTCAATAGCGCTAAAATATTTTTCACTCAAATCATCATTTAAGATTTTTCCATGCTTATTA
GCAAAATAAACTTCTTTCACCCCACCATGCATTTTTTCTTTGAGATACAAGTCTTTTCGGTTGCAAATAA
AAGGGGCTTCATTCATTCCCACAAGAAAATTATAAAACTCGCATTGTTTGGAGTAAATAATGCCATCTTT
GGTGTATTCTTTCAATCTAGTGGGGTGGTATTTACTCAATAGCTCTTCTATGAGCTCTATCCTATCCTTG
AAGTTCTCAAGCTTGGCTCTAATAATCCTTTGAAACTCTTCAAAATTATTGTCTGCAAAATGCTTTTTAT
TCATAACGGGTTCATTGAGAGTGTCTAATAAATCTTGCTCTATGGTGAGATAAAAACTAATATCATAAAA
ACTTTCTCTTTTTTGCTTCTCATTATAGGCTCGCATAAAATCATTAGAAAAAGCAAGACCATAGTCCCTA
TTGGTTTCATCAATAACGATTTTCTTTTTAACAGTGTGAAAATAAAATTTGAATTCAGGGGTAACAAAAT
TCCTAAAAACGCTATAAATAGAAGCGTGTAACTCTATGAGATCTTTTTTGGAAGTGGTTAAAAAATCAAT
GCCCCCCAATTTGATTGTGCCTAAAAGAGAATAGTTGTTAGTAAGGATCACCCCATCATCTAAAAAACAT
TCATAGTTATTCGCTAGATAGGAGTTTGCAGCGCTCACAAGCCTGTCTTCTCTGTTGGGATTCAAGTGGA
TGTCATTAGCCATTTCCTTACTAGGCTTCATGGAAAAAATGCTCATGAACGCTTTGTTTTTCACGCCCTT
AAACAAAAAAGGTTTTTTAAATTTCATCGCTCGCTCCATTCTTTGATAAAGCCTATAATCTTTCTTGAAT
CCAAGAGCTACAAGCACAATAACAATCGCTACAATCAAAACAGGTTCATAGGCTTGAAAAAGAATAACAG
ATAATACAATTGTTACAAATAATATAAATATAGAGGAATAAATAAAAGTTTCAGGGAAACCAAACAACCT
ATTCCCCCCATCAAACAAGACTTTAAAAAAGGGATTGACACCCTTTTGCATGTCTGCTTTAAGCTCTTCT
ATTTTTTGAAACTGCCGCTTTTGAACCTCTTGCTCTATGATTAGCTTTTTTTGTTCGTCAGCTTGTTTGC
TTGCCACAAACA
Protein Sequence 
>gi|208434465|ref|YP_002266131.1| cag pathogenicity island protein E [Helicobacter pylori G27] MFVASKQADEQKKLIIEQEVQKRQFQKIEELKADMQKGVNPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQAYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAANSYLANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTVKKKIVIDETNRDYGLAFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLSKYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEISEYAPKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSLVLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFAKHCSFITLPFIFDVTSNNFADFIAMRAMSFDGNQDNNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFAYNFPANVSKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEKDENGNSISFSLADSNTLAAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLDFSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQSITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLKILSTDTVFVKEIDKIIQNHSIIDKYQALRQMYQQIEEY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils (Ogura et al., 2000).
COG COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Ogura et al., 2000: Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, Yoshida H, Shiratori Y, Omata M. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. The Journal of experimental medicine. 2000; 192(11); 1601-1610. [PubMed: 11104802].