Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 347 HP1206 Helicobacter 898800 15645820 HP1206 NP_207998.1 multidrug resistance protein (hetA) Virulence factor MUTATION: a HP1206 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1132V, under V: Defense mechanisms 12668646 348 flgL Helicobacter 898810 15644923 HP0295 NP_207093.1 flagellar hook-associated protein FlgL Virulence factor MUTATION: a flgL mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1344N, under N: Cell motility 12668646 349 HP0350 Helicobacter 898835 15644978 HP0350 NP_207148.1 hypothetical protein Virulence factor MUTATION: a HP0350 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 350 HP0758 Helicobacter 898859 15645377 HP0758 NP_207551.1 hypothetical protein Virulence factor MUTATION: a HP0758 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG2056R, under R: General function prediction only 12668646 351 HP0392 Helicobacter 898900 15645020 HP0392 NP_207190.1 histidine kinase (cheA) Virulence factor MUTATION: a HP03292 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0643NT, under N: Cell motility; T: Signal transduction mechanisms 12668646 352 HP0797 Helicobacter 898975 15645416 HP0797 NP_207590.1 flagellar sheath adhesin hpaA Virulence factor MUTATION: a HP0797 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 353 HP0169 Helicobacter 899006 15644798 HP0169 NP_206968.1 collagenase (prtC) Virulence factor MUTATION: a HP0169 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0826O, under O: Posttranslational modification, protein turnover, chaperones 12668646 354 HP0254 Helicobacter 899058 15644882 HP0254 NP_207052.1 outer membrane protein (omp8) Virulence factor MUTATION: a HP0254 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 355 HP0017 Helicobacter 899097 15644650 HP0017 NP_206819.1 virB4 homolog (virB4) Virulence factor MUTATION: a HP0017 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport 12668646 356 ureC Helicobacter 899104 15644702 HP0072 NP_206872.1 urease subunit alpha Virulence factor MUTATION: a ureC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0804E, under E: Amino acid transport and metabolism 12668646 357 hemC Helicobacter 899174 15644865 HP0237 NP_207035.1 porphobilinogen deaminase Virulence factor MUTATION: a hemC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0181H, under H: Coenzyme transport and metabolism 12668646 358 HP0055 Helicobacter 899191 15644686 HP0055 NP_206856.1 proline permease (putP) Virulence factor MUTATION: a HP0055 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0591ER, under E: Amino acid transport and metabolism; R: General function prediction only 12668646 359 HP0289 Helicobacter 899197 15644917 HP0289 NP_207087.1 toxin-like outer membrane protein Virulence factor MUTATION: a HP0289 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG5651N, under N: Cell motility 12668646 360 HP0360 Helicobacter 899217 15644988 HP0360 NP_207158.1 UDP-glucose 4-epimerase Virulence factor MUTATION: a HP0360 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1087M, under M: Cell wall/membrane/envelope biogenesis 12668646 361 HP0366 Helicobacter 899219 15644994 HP0366 NP_207164.1 spore coat polysaccharide biosynthesis protein C Virulence factor MUTATION: a HP0366 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0399M, under M: Cell wall/membrane/envelope biogenesis 12668646 362 fliS Helicobacter 899333 15645372 HP0753 NP_207546.1 flagellar protein FliS Virulence factor MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. COG1516NUO, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport; O: Posttranslational modification, protein turnover, chaperones 12018657 363 HP0788 Helicobacter 899346 15645407 HP0788 NP_207581.1 hypothetical protein Virulence factor MUTATION: a HP0788 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 364 flgE Helicobacter 899399 15645489 HP0870 NP_207664.1 flagellar hook protein FlgE Virulence factor MUTATION: a flgE mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1749N, under N: Cell motility 12668646 365 flgD Helicobacter 899436 15645523 HP0907 NP_207699.1 flagellar basal body rod modification protein Virulence factor MUTATION: a flgD mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1843N, under N: Cell motility 12668646 366 surE Helicobacter 899459 15645546 HP0930 NP_207722.1 stationary phase survival protein SurE Virulence factor MUTATION: a surE mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0496R, under R: General function prediction only 12668646 367 HP0973 Helicobacter 899505 15645588 HP0973 NP_207764.1 hypothetical protein Virulence factor MUTATION: a HP0973 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 368 fliM Helicobacter 899566 15645645 HP1031 NP_207821.1 flagellar motor switch protein FliM Virulence factor MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. COG1868N, under N: Cell motility 12018657 369 HP1082 Helicobacter 899618 15645696 HP1082 NP_207873.1 multidrug resistance protein (msbA) Virulence factor MUTATION: a HP1082 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1132V, under V: Defense mechanisms 12668646 370 HP1091 Helicobacter 899627 15645705 HP1091 NP_207882.1 alpha-ketoglutarate permease (kgtP) Virulence factor MUTATION: a HP1091 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 371 HP1092 Helicobacter 899628 15645706 HP1092 NP_207883.1 flagellar basal-body rod protein (flgG) Virulence factor MUTATION: a HP1092 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG4786N, under N: Cell motility 12668646 372 flgC Helicobacter 899733 15646165 HP1558 NP_208349.1 flagellar basal body rod protein FlgC Virulence factor MUTATION: a flgC mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1558N, under N: Cell motility 12668646 373 HP1525 Helicobacter 899766 15646133 HP1525 NP_208315.1 hypothetical protein Virulence factor MUTATION: a HP1525 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 374 HP1506 Helicobacter 899785 15646115 HP1506 NP_208297.1 glutamate permease (gltS) Virulence factor MUTATION: a HP1506 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0786E, under E: Amino acid transport and metabolism 12668646 375 HP1486 Helicobacter 899806 15646095 HP1486 NP_208277.1 hypothetical protein Virulence factor MUTATION: a HP1486 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0842V, under V: Defense mechanisms 12668646 376 HP1421 Helicobacter 899874 15646030 HP1421 NP_208212.1 conjugative transfer regulon protein (trbB) Virulence factor MUTATION: a HP1421 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0630NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 12668646 377 fliI Helicobacter 899875 15646029 HP1420 NP_208211.1 flagellum-specific ATP synthase Virulence factor MUTATION: a fliI mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 12668646 378 fliQ Helicobacter 899876 15646028 HP1419 NP_208210.1 flagellar biosynthesis protein FliQ Virulence factor MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. COG1987NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 12018657 379 HP0601 Helicobacter 899977 15645226 HP0601 NP_207396.1 flagellin A Virulence factor MUTATION: a HP0601 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1344N, under N: Cell motility 12668646 380 fliP Helicobacter 899979 15645308 HP0685 NP_207479.1 flagellar biosynthesis protein FliP Virulence factor MUTATION: a fliP mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1338NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 12668646 381 HP0067 Helicobacter 899986 15644697 HP0067 NP_206867.1 urease accessory protein (ureH) Virulence factor MUTATION: a HP0067 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0829O, under O: Posttranslational modification, protein turnover, chaperones 12668646 382 HP0071 Helicobacter 899995 15644701 HP0071 NP_206871.1 urease accessory protein (ureI) Virulence factor MUTATION: a HP0071 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 383 HP0393 Helicobacter 899996 15645021 HP0393 NP_207191.1 chemotaxis protein (cheV) Virulence factor MUTATION: a HP0393 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0835NT, under N: Cell motility; T: Signal transduction mechanisms 12668646 384 fliD Helicobacter 900004 15645371 HP0752 NP_207545.1 flagellar capping protein Virulence factor MUTATION: a fliD mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1345N, under N: Cell motility 12668646 385 HP0486 Helicobacter 900059 15645113 HP0486 NP_207283.1 hypothetical protein Virulence factor MUTATION: a HP0486 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 386 HP0288 Helicobacter 900108 15644916 HP0288 NP_207086.1 hypothetical protein Virulence factor MUTATION: a HP0288 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 387 HP0245 Helicobacter 900123 15644873 HP0245 NP_207043.1 hypothetical protein Virulence factor MUTATION: a HP0245 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 388 HP0073 Helicobacter 900171 15644703 HP0073 NP_206873.1 bifunctional urease subunit gamma/beta Virulence factor MUTATION: a HP0073 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0832E, under E: Amino acid transport and metabolism 12668646 389 HP0232 Helicobacter 900177 15644860 HP0232 NP_207030.1 hypothetical protein Virulence factor MUTATION: a HP0232 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] 12668646 390 HP0302 Helicobacter 900194 15644930 HP0302 NP_207100.1 dipeptide ABC transporter, ATP-binding protein (dppF) Virulence factor MUTATION: a HP0302 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1123R, under R: General function prediction only 12668646 391 flgH Helicobacter 900196 15644953 HP0325 NP_207123.1 flagellar basal body L-ring protein Virulence factor MUTATION: a flgH mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG2063N, under N: Cell motility 12668646 392 HP0397 Helicobacter 900244 15645025 HP0397 NP_207195.1 phosphoglycerate dehydrogenase (serA) Virulence factor MUTATION: a HP0397 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG0111HE, under H: Coenzyme transport and metabolism; E: Amino acid transport and metabolism 12668646 393 HP0714 Helicobacter 900248 15645336 HP0714 NP_207508.1 RNA polymerase factor sigma-54 Virulence factor MUTATION: a HP0714 mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1508K, under K: Transcription 12668646 394 fliF Helicobacter 900354 15644979 HP0351 NP_207149.1 flagellar MS-ring protein Virulence factor MUTATION: a fliF mutant was attenuated for gastric colonization in a gerbil model [Ref6332:Kavermann et al., 2003] COG1766NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 12668646 395 flaA Helicobacter 889160 15611615 jhp0548 NP_223266.1 flagellin A Virulence factor MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 396 cagA Helicobacter 889201 15611562 jhp0495 NP_223213.1 cag island protein, CYTOTOXICITY ASSOCIATED IMMUNODOMINANT ANTIGEN Virulence factor MUTATION: attenuated in monkeys [Ref6335:Hornsby et al., 2008]. 18395086 397 cagP Helicobacter 889236 15611551 jhp0484 NP_223202.1 cag island protein Virulence factor MUTATION: mutant strain adhered less to AGS cells than wild-type strain [Ref6333:Zhang et al., 2002]. 12018657 398 napA Helicobacter 889403 15611298 jhp0228 NP_222949.1 NEUTROPHIL-ACTIVATING PROTEIN A Virulence factor MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. COG0783P, under P: Inorganic ion transport and metabolism 16758245 399 flaB Helicobacter 889505 15611177 jhp0107 NP_222828.1 flagellin Virulence factor MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 400 babA Helicobacter 890058 15611900 jhp0833 NP_223551.1 outer membrane protein - adhesin Virulence factor MUTATION: modified strain eliminated binding to LEB and gastric tissue [Ref6337:Styer et al., 2010]. 20123715 401 vacA Helicobacter 890075 15611886 jhp0819 NP_223537.1 vacuolating cytotoxin Virulence factor MUTATION: knockout did not result in gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. 20046046 402 ureG Helicobacter 890411 15611134 jhp0063 NP_222785.1 UREASE ACCESSORY PROTEIN Virulence factor MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. COG0378OK, under O: Posttranslational modification, protein turnover, chaperones; K: Transcription 8063376 3376 flaA Helicobacter 7009743 210134803 HPP12_0609 YP_002301242.1 flagellin A Virulence factor MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3377 hopH Helicobacter 7009784 210134844 HPP12_0650 YP_002301283.1 outer membrane protein HopH Virulence factor MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. 17054063 3378 homB Helicobacter 7009855 210134914 HPP12_0721 YP_002301353.1 outer membrane protein HomB Virulence factor MUTATION: knockout strains reduced damage and adherence to human gastric epithelial cells [Ref6803:Oleastro et al., 2008]. 18811585 3379 vacA Helicobacter 7010020 210135077 HPP12_0884 YP_002301516.1 vacuolating cytotoxin VacA Virulence factor MUTATION: knockout did not cause gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. 20046046 3380 babA Helicobacter 7010027 210135084 HPP12_0891 YP_002301523.1 outer membrane protein BabA Virulence factor MUTATION: strains slacking BabA cannot adhere to Leb, expressed on gastric epithelium [Ref6804:Solnick et al., 2004]. 14762173 3381 alpA Helicobacter 7010048 210135103 HPP12_0910 YP_002301542.1 outer membrane protein HopC/AlpA Virulence factor MUTATION: mutant showed severe reduction in ability to bind to gastric cell line [Ref6805:Odenbreit et al., 1999]. 10200971 3382 alpB Helicobacter 7010049 210135104 HPP12_0911 YP_002301543.1 outer membrane protein HopB/AlpB Virulence factor MUTATION: mutant showed severe reduction in ability to bind to gastric cell line [Ref6805:Odenbreit et al., 1999]. 10200971 3383 hopZ Helicobacter 7010375 210134208 HPP12_0007 YP_002300647.1 outer membrane protein HopZ Virulence factor MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. 10454640 3384 ureG Helicobacter 7010440 210134273 HPP12_0072 YP_002300712.1 urease accessory protein UreG Virulence factor MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. COG0378OK, under O: Posttranslational modification, protein turnover, chaperones; K: Transcription 8063376 3385 flaB Helicobacter 7010487 210134318 HPP12_0117 YP_002300757.1 flagellin B Virulence factor MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3386 horB Helicobacter 7010497 210134328 HPP12_0127 YP_002300767.1 outer membrane protein HorB Virulence factor MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. 17492999 3387 napA Helicobacter 7010614 210134443 HPP12_0243 YP_002300882.1 neutrophil-activating protein A Virulence factor MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. COG0783P, under P: Inorganic ion transport and metabolism 16758245 3388 cagP Helicobacter 7010918 210134738 HPP12_0543 YP_002301177.1 cag pathogenicity island protein P Virulence factor MUTATION: mutant strain adhered less to AGS cells than wild-type strain [Ref6333:Zhang et al., 2002]. 12018657 3389 cagE Helicobacter 7010926 210134746 HPP12_0551 YP_002301185.1 cag pathogenicity island protein E VirB4-like protein Virulence factor MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils [Ref6808:Ogura et al., 2000]. COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport 11104802 3390 hopZ Helicobacter 6962890 208433984 HPG27_8 YP_002265650.1 outer membrane protein Virulence factor MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. 10454640 3391 ureG Helicobacter 6962945 208434035 HPG27_63 YP_002265701.1 urease accessory protein Virulence factor MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. COG0378OK, under O: Posttranslational modification, protein turnover, chaperones; K: Transcription 8063376 3392 flaB Helicobacter 6962991 208434076 HPG27_107 YP_002265742.1 flagellin B Virulence factor MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3393 horB Helicobacter 6963000 208434085 HPG27_116 YP_002265751.1 outer membrane protein Virulence factor MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. 17492999 3394 babA Helicobacter 6963184 208434264 HPG27_298 YP_002265930.1 outer membrane protein Virulence factor MUTATION: strains lacking BabA cannot adhere to Leb, expressed on gastric epithelium [Ref6804:Solnick et al., 2004]. 14762173 3395 cagE Helicobacter 6963392 208434465 HPG27_503 YP_002266131.1 cag pathogenicity island protein E Virulence factor MUTATION: knock out deprived wild-type of the pathogenicity for gastritis and gastric ulcer in Mongolian gerbils [Ref6808:Ogura et al., 2000]. COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport 11104802 3396 flaA Helicobacter 6963451 208434522 HPG27_562 YP_002266188.1 flagellin A Virulence factor MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3397 hopH Helicobacter 6963488 208434559 HPG27_599 YP_002266225.1 outer membrane protein Virulence factor MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. 17054063 3398 sabA Helicobacter 6963569 208434635 HPG27_680 YP_002266301.1 outer membrane protein Virulence factor MUTATION: deletion mutant lost ability to bind to sialyl-Lewis antigens [Ref6809:Aspholm et al., 2006], and had no neutrophil-activating capacity [Ref6810:Unemo et al., 2005]. 17121461, 15689619 3399 vacA Helicobacter 6963731 208434795 HPG27_840 YP_002266461.1 vacuolating cytotoxin A Virulence factor MUTATION: knockout did not cause gastric ulcers in mice compared to wild type [Ref6338:Isomoto et al., 2010]. 20046046 3801 flaB Helicobacter 8207576 254778835 HELPY_0115 YP_003056940.1 Flagellin B (Flagellin N) Virulence factor MUTATION: mutant strains showed reduced motility and colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3802 napA Helicobacter 8207634 254778949 HELPY_0248 YP_003057054.1 Neutrophil activating protein NapA (bacterioferritin) Virulence factor MUTATION: deletion impaired adherence to host cells [Ref6336:Petersson et al., 2006]. COG0783P, under P: Inorganic ion transport and metabolism 16758245 3803 hopH Helicobacter 8207891 254779375 HELPY_0733 YP_003057480.1 Outer membrane protein HopH Virulence factor MUTATION: mutant strain showed reduction in bacterial adherence to gastric epithelia in vitro [Ref6802:Dossumbekova et al., 2006]. 17054063 3804 hopZ Helicobacter 8208349 254778745 HELPY_0007 YP_003056850.1 Outer membrane protein HopZ; putative signal peptide Virulence factor MUTATION: knockout strain reduced adherence to human gastric epithelial cells [Ref6806:Peck et al., 1999]. 10454640 3805 flaA Helicobacter 8208748 254779405 HELPY_0771 YP_003057510.1 Flagellin A Virulence factor MUTATION: mutant strains showed reduced colonization in piglets [Ref6334:Eaton et al., 1996]. COG1344N, under N: Cell motility 8698465 3806 tlyA Helicobacter 8208922 254779055 HELPY_0367 YP_003057160.1 Pore-forming cytolysin Virulence factor MUTATION: mutated strain showed a reduction in adherence ability [Ref6333:Zhang et al., 2002]. COG1189J, under J: Translation, ribosomal structure and biogenesis 12018657 3807 horB Helicobacter 8208956 254778844 HELPY_0126 YP_003056949.1 Outer membrane protein HorB; putative signal peptide Virulence factor MUTATION: knockout strain showed reduced adhesion and colonization in mice [Ref6807:Snelling et al., 2007]. 17492999 3808 ureG Helicobacter 8209081 254778794 HELPY_0064 YP_003056899.1 Urease accessory protein UreG Virulence factor MUTATION: urease-negative strain showed reduced colonization in gnotobiotic piglets [Ref6339:Eaton and Krakowka, 1994]. COG0378OK, under O: Posttranslational modification, protein turnover, chaperones; K: Transcription 8063376 4864 HP0859 Helicobacter pylori 26695 899388 15645478 HP0859 AE000511 NP_207653 ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) Virulence factor MUTATION: HP0859 knockout mutant exhibited a severe truncation of LPS, a decreased growth rate, and a higher susceptibility to novobiocin. Disruption of HP0859 also reduced the adhesive capacity of H. pylori to AGS cells [Ref7282:Chang et al., 2011]. COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 21256827 4870 LPS Helicobacter pylori Virulence factor MUTATION: Insertional inactivation of HP0479 resulted in formation of a truncated LPS molecule lacking an alpha-1,6-glucan-, dd-heptose-containing outer core region and O-chain polysaccharide. Introduction of the HP0479 mutation into the H. pylori mouse-colonizing Sydney (SS1) strain and the clinical isolate PJ1, which expresses dd-heptoglycan, resulted in the loss of colonization in a mouse model [Ref7296:Hiratsuka et al., 2005]. 16030209