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sabA |
| Victor ID |
3398 |
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Gene Name |
sabA |
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Sequence Strain (Species/Organism) |
Helicobacter |
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NCBI Gene ID |
6963569
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NCBI Protein GI |
208434635
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Locus Tag |
HPG27_680 |
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Protein Accession |
YP_002266301.1 |
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Other Database IDs |
UniProtKB-ID: B5Z786_HELPG
UniRef100: UniRef100_B5Z786
UniRef90: UniRef90_D7FE80
UniRef50: UniRef50_D7FE80
UniParc: UPI000181C396
EMBL: CP001173
EMBL-CDS: ACI27435.1
RefSeq_NT: NC_011333.1
GenomeReviews: CP001173_GR
KEGG: hpg:HPG27_680
HOGENOM: HBG501479
OMA: QNANNIE
ProtClustDB: CLSK496176
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Taxonomy ID |
563041
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Gene Starting Position |
746188 |
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Gene Ending Position |
748143 |
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Gene Strand (Orientation) |
- |
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Protein Name |
outer membrane protein |
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DNA Sequence |
>gi|208433976:746188-748143 Helicobacter pylori G27, complete genome
TTTAATAAGCGAACACATAATTGAGATACACGCTATAGAGCCTTCGGTATTGCAATTGAGTGCCTAGAAA
AGAATAGTAATTCGTGTTAATGGTGGGGATTTTAATGCCTAATTCTATGCCATGTTGCGCGGAATGTTCG
CTGTCTTTTTTCTTAGCTGTAGCGAGATTCGTCCTCAAGCCGAGATTGAACAAAAATTGGAAATTAGAAG
TATTGACTTTCGCGCTATAAGGGTTATTGAACGCGGTTAAATTCACATATTGAGAATTAAGCCATGTAGT
CCCTGCTAGTTGGATACCTCCAAAAAGACCCACGGAGAGCTTGTTGTTCTTTCTTGTAATGCTATCGTTG
ATAATATTCACTAACAAATCGCTCCCACCGCCATAAGTCCATATATCAGAAGACGAATTAAAAAAGCTGG
ATTTGATATAGCCGTGGTTGTAATCAAAGAAGCCGTAATACCTTAATCCCCATCTTTTGCTTTCGCCAAA
GAATTGCTTATAACCCACTTGAACGCCAAGCCCATTCATTGCGCCGTTATTGTTTTGAGAGCTGATCATG
CCCACTTTTTTAAAGGGGTTATTGCTCATCGCCGCTAAAGCTTGGTTAAGATTGGATTGCTGCTCTGGAT
TGATTTGGTAGTTGTATTGGCCCGCTGCTGGGGCGTTTTTATCGTGAGGTAGCGTAACAATGTCTTTTGT
ATTGACTTGGTTATAGGGGAGTTTAGAAATTTCTTCGCTCAAATTATTAGCGTTGCTATAGGCTGTTACA
ATGTTTGCTTGATTGGATTTTAGGTTATAAACATCTCTAGCCACGCTTAAAGCCGCATCCACCCGGTTAC
CATAATAACTCACGTTGTTTTTAATCGTCTGAACTTCTTGGTTCAAATTCACCTCCTGTCTGTAAGGGTT
AGTAGGCGTTTGACCCAAATTGGGTATTTTCAAGTAGGCTTTCTCTAAATAACGATACTGATCTTTAGGG
ATGGAATTAAAGAGGTTGAAAATGTCTTTGGCGTAAGAGATGATTTGCTTTTGGTTTTGAGCGAAAGTGT
AGATGTCTTTAGCGAAATTAGGGTTTGTTTGAGTCCCTGTGGCTTGAGCTTGCAAACTAGCAGATAGGGT
GTGGTTATTTTGAGAAAGCGTAACCGCTTGTTGCAAAATAGGTATCATCGCCTTAATGTTGTTAAACACC
GCGTATTGCGTTGGGTAATTAGTGGATGTGATAGCGCCGGACGCGTTTGAAACGCCACTGATGACGATAT
TTTTCCACATCATAGCCGTCTTAGTGTTTGCGATCAAGTCCATAAGCTGTTGCGCCAAATTAAGAGCGTT
GCTCACGGTTGAGTTTGGCGGGTTTGATGCTGAGTCTGTTGCAGCGCATCCGGATAAAGCGCAAAGATTG
TTGCCTTTAGTGGTAGCGTTTTGTTGAGCTGCTTGGAGGTTTTCAGCGAGTTTTTTCATCTCATCATAAG
TGGTTTGATTCATAGCGCAGTTTTCAGGTCCTGAGCAGTTTTCTACAATCGTTTTAAAATGAGGGTTACC
CTGAACTCTAGAGGCTTGTTTACCACTGCCCACAAAAAAAGTGAAGTAGTTCCCCGCATAAAGACTCCAA
AAACCCAATACCGAAGTGATAACGGCTTGCACGGCGTTGAAGATGGGCGATTGGGTGGTGCTGTTATAGT
TGTTGTTGGTAAAGCTTTTTAAATAGTTTAAAGAGCTATTGACCAGCTCAATGTTGTTGGCGTTTTGAAT
GCTTTGCTTCAACGAAGCCACTTGATTTAAATACTGGTTTAATTGCTCGTATTTTTCGTTCAAGTTTTTC
AATTCGCCGGTGTTTTTGACCATTTGCACCGCTTCGCCGATTTGATAGCCCGCGCTCACAAAAAAGCCAT
TGTCTTCAGCGTGCAAGAGCGATGAAGCGAGAGAGAGAGAGAGAGAGAGTAAAATTGTCTTTTTCA
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Protein Sequence |
>gi|208434635|ref|YP_002266301.1| outer membrane protein [Helicobacter pylori G27] MKKTILLSLSLSLASSLLHAEDNGFFVSAGYQIGEAVQMVKNTGELKNLNEKYEQLNQYLNQVASLKQSIQNANNIELVNSSLNYLKSFTNNNYNSTTQSPIFNAVQAVITSVLGFWSLYAGNYFTFFVGSGKQASRVQGNPHFKTIVENCSGPENCAMNQTTYDEMKKLAENLQAAQQNATTKGNNLCALSGCAATDSASNPPNSTVSNALNLAQQLMDLIANTKTAMMWKNIVISGVSNASGAITSTNYPTQYAVFNNIKAMIPILQQAVTLSQNNHTLSASLQAQATGTQTNPNFAKDIYTFAQNQKQIISYAKDIFNLFNSIPKDQYRYLEKAYLKIPNLGQTPTNPYRQEVNLNQEVQTIKNNVSYYGNRVDAALSVARDVYNLKSNQANIVTAYSNANNLSEEISKLPYNQVNTKDIVTLPHDKNAPAAGQYNYQINPEQQSNLNQALAAMSNNPFKKVGMISSQNNNGAMNGLGVQVGYKQFFGESKRWGLRYYGFFDYNHGYIKSSFFNSSSDIWTYGGGSDLLVNIINDSITRKNNKLSVGLFGGIQLAGTTWLNSQYVNLTAFNNPYSAKVNTSNFQFLFNLGLRTNLATAKKKDSEHSAQHGIELGIKIPTINTNYYSFLGTQLQYRRLYSVYLNYVFAY
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Molecule Role |
Virulence factor |
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Molecule Role Annotation |
MUTATION: deletion mutant lost ability to bind to sialyl-Lewis antigens (Aspholm et al., 2006), and had no neutrophil-activating capacity (Unemo et al., 2005). |
| References |
Aspholm et al., 2006: Aspholm M, Olfat FO, Nordén J, Sondén B, Lundberg C, Sjöström R, Altraja S, Odenbreit S, Haas R, Wadström T, Engstrand L, Semino-Mora C, Liu H, Dubois A, Teneberg S, Arnqvist A, Borén T. SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. PLoS pathogens. 2006; 2(10); e110. [PubMed: 17121461].
Unemo et al., 2005: Unemo M, Aspholm-Hurtig M, Ilver D, Bergström J, Borén T, Danielsson D, Teneberg S. The sialic acid binding SabA adhesin of Helicobacter pylori is essential for nonopsonic activation of human neutrophils. The Journal of biological chemistry. 2005; 280(15); 15390-15397. [PubMed: 15689619].
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