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HP0017

Victor ID 355
Gene Name HP0017
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 899097
NCBI Protein GI 15644650
Locus Tag HP0017
Protein Accession NP_206819.1
Other Database IDs UniProtKB-ID: O24862_HELPY
UniRef100: UniRef100_O24862
UniRef90: UniRef90_B5Z687
UniRef50: UniRef50_Q17VD3
UniParc: UPI00000D3089
EMBL: AE000511
EMBL-CDS: AAD07086.1
RefSeq_NT: NC_000915.1
DIP: DIP-3110N
MINT: MINT-174442
GenomeReviews: AE000511_GR
KEGG: hpy:HP0017
NMPDR: fig|85962.1.peg.17
TIGR: HP_0017
HOGENOM: HBG501516
OMA: LMHANRE
ProtClustDB: CLSK694578
Taxonomy ID 85962
Gene Starting Position 14247
Gene Ending Position 16610
Gene Strand (Orientation) +
Protein Name virB4 homolog (virB4)
DNA Sequence 
>gi|15644634:14247-16610 Helicobacter pylori 26695, complete genome
AATGTTAGAAAAGCTTTTAAGCGCTATCAAACAAAAGGTTTCAAACTATTTTTTAGGGGTTTTGCCTAAA
AGCTATTCTATGAGCGAAGAAAACAACATTTTAGGCTTGTATGATGAGCATTTCTTGCTCACTAAAAACG
AAAACTTAGTGGGCATCCTCCGTTTAGAAGGGGTTAGCTACACCCATTTAAGCACAGAGCAATTGCAAGA
TCTTTTCACCGAGCGCCAGATGGCGTTGGATTCTTTAGAAAAAGTCGTGGCGCGCCTTGTGGTTAAAAGG
CGTAAAATTGATCACCAACAAAACATTCAATCTGATTCTCAATACTTGCAAGCGATTTTGAATCAATTTG
AAAACAAAGAAGTGTATGAAAATCAGTATTTTTTAGTTTTAGAAAGCACTCACTCTTTGCATGGCGTTTT
GGAGCATAAGAAAAAATCTCTCATGCATGCTAATAGGGAAAATTTTAAGGATATTCTCTCTTATAAAGCG
CATTTTTTGCAAGAAACTTTAAAAAGCTTAGAAATCCAGCTCAAAAATTATGCCCCCAAACTCTTAAGCT
CCAAAGAGGTTTTGAATTTTTATGCGGAATACATTAATGGGTTTGATCTCCCCTTAAAACCCTTAGTAGG
GGGGTATTTGAGCGATAGCTATATCGCTAGTTCTATCACTTTTGAAAAAGATTATTTCATTCAAGAAAGC
TTTAATCAAAAAACCTACAACCGCTTGATTGGCATTAAAGCTTATGAGAGCGAAAGGATCACTTCTATAG
CGATCGGAGCGCTTTTATACCAAGAAACGCCTTTAGATATTATCTTCTCTATAGAGCCTATGAGTGTGCA
TAAAACGCTGAGTTTTTTAAAAGAGAGGGCCAAGTTTAGCATGTCCAATCTCGTTAAAAACGAGCTATTA
GAATACCAAGAACTGGTCAAAACCAAACGCCTATCCATGCAAAAATTCGCCCTAAACATTCTTATCAAAG
CCCCTAGTTTAGAGAATTTAGACGCTCAAACAAGCTTGGTTTTAGGGCTTTTATTTAAAGAAAATTTAGT
GGGCGTTATAGAAACTTTTGGCTTGAAGGGGGGGTATTTTTCCTTTTTCCCTGAACGCATCCACTTAAAC
CACCGCTTGCGTTTTTTAACCTCTAAAGCCTTAGCGTGTTTAATGGTGTTTGAAAGGCAAAATTTAGGTT
TTAAGGCTAATTCATGGGGGAATAGCCCTTTGAGCGTGTTTAAAAATTTGGATTATTCCCCTTTTTTATT
CAATTTCCACAACCAAGAAGTGAGCCACAAGAACGCCAAAGAAATCGCCAGAGTGAATGGGCATACTTTA
ATCATAGGGGCTACTGGGAGCGGTAAAAGCACGCTGATTAGCTTTTTAATGATGAGCGCTTTGAAATACC
AAAACATGCGCCTTTTAGCTTTTGATAGGATGCAGGGGCTGTATTCTTTCACAAAATTTTTTAAAGGGCA
TTACCATGACGGCCAATCTTTTAGCATCAACCCCTTTTGTTTAGAGCCTAATTTGCAGAATCTAGAATTT
TTGCAATCCTTCTTTTTGAGCATGTTTGATCTTGCCCCTTCAAGGGATAAAGAAGCCTTGGAAGATATGA
ATGCGATTTCTAGCGCGATTAAGAGCCTTTATGAGACCTTATACCCTAAAGCTTTTAGTTTGCTAGACTT
TAAAGAAACGCTTAAAAGAACTTCATCTAACCAATTGGGTTTGAGTTTAGAGCCGTATTTGAATAACCCC
CTTTTTAACGCTTTGAATGATGCGTTCAACTCCAACGCTTTTTTAAATGTGATAAACCTGGATACTATCA
CCCAAAATCCTAAAGACTTAGGGCTTTTAGCCTATTATTTGTTTTATAAAATCTTAGAAGAATCCAGGAA
AAACGACAGCGGCTTTTTGGTTTTTTTAGACGAGTTTAAATCCTATGTGGAAAACGATTTATTGAACACT
AAAATCAACGCTTTAATCACGCAAGCCAGAAAAGCTAATGGCGTGGTGGTGTTGGCCTTGCAAGATATTT
ACCAATTAAGCGGGGTTAAAAACGCTCATAGTTTTTTAAGCAACATGGGGACTCTCATTTTGTACCCGCA
AAAAAACGCTAGGGAGTTGAAACACAATTTCAATGTGCCTTTGAGCGAAACTGAAATTTCTTTTTTAGAA
AACACCCCTTTGTATGCCAGGCAGGTTTTAGTCAAAAATCTGGGTAACGGGAGCTCTAACATGATTGATG
TGAGTTTGGAGAGTTTGGGGCGTTATTTGAAAATCTTTAATTCGGATTCTAGCCATGTGAGTAAAGTGAA
AGCGTTACAAAAAGACTACCCTACAGAGTGGCGCGAGAAACTTTTGAGGAGCTA
Protein Sequence 
>gi|15644650|ref|NP_206819.1| protein VirB4 [Helicobacter pylori 26695] MLEKLLSAIKQKVSNYFLGVLPKSYSMSEENNILGLYDEHFLLTKNENLVGILRLEGVSYTHLSTEQLQDLFTERQMALDSLEKVVARLVVKRRKIDHQQNIQSDSQYLQAILNQFENKEVYENQYFLVLESTHSLHGVLEHKKKSLMHANRENFKDILSYKAHFLQETLKSLEIQLKNYAPKLLSSKEVLNFYAEYINGFDLPLKPLVGGYLSDSYIASSITFEKDYFIQESFNQKTYNRLIGIKAYESERITSIAIGALLYQETPLDIIFSIEPMSVHKTLSFLKERAKFSMSNLVKNELLEYQELVKTKRLSMQKFALNILIKAPSLENLDAQTSLVLGLLFKENLVGVIETFGLKGGYFSFFPERIHLNHRLRFLTSKALACLMVFERQNLGFKANSWGNSPLSVFKNLDYSPFLFNFHNQEVSHKNAKEIARVNGHTLIIGATGSGKSTLISFLMMSALKYQNMRLLAFDRMQGLYSFTKFFKGHYHDGQSFSINPFCLEPNLQNLEFLQSFFLSMFDLAPSRDKEALEDMNAISSAIKSLYETLYPKAFSLLDFKETLKRTSSNQLGLSLEPYLNNPLFNALNDAFNSNAFLNVINLDTITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFLDEFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKHNFNVPLSETEISFLENTPLYARQVLVKNLGNGSSNMIDVSLESLGRYLKIFNSDSSHVSKVKALQKDYPTEWREKLLRS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a HP0017 mutant was attenuated for gastric colonization in a gerbil model (Kavermann et al., 2003)
COG COG3451U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Kavermann et al., 2003: Kavermann H, Burns BP, Angermuller K, Odenbreit S, Fischer W, Melchers K, Haas R. Identification and characterization of Helicobacter pylori genes essential for gastric colonization. The Journal of experimental medicine. 2003; 197(7); 813-822. [PubMed: 12668646].