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alpA

Victor ID 3381
Gene Name alpA
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 7010048
NCBI Protein GI 210135103
Locus Tag HPP12_0910
Protein Accession YP_002301542.1
Other Database IDs UniProtKB-ID: B6JMD4_HELP2
UniRef100: UniRef100_B6JMD4
UniRef90: UniRef90_B2UU63
UniRef50: UniRef50_B2UU63
UniParc: UPI00018336A4
EMBL: CP001217
EMBL-CDS: ACJ08062.1
RefSeq_NT: NC_011498.1
GenomeReviews: CP001217_GR
KEGG: hpp:HPP12_0910
HOGENOM: HBG501865
ProtClustDB: CLSK496273
Taxonomy ID 570508
Gene Starting Position 962719
Gene Ending Position 964275
Gene Strand (Orientation) +
Protein Name outer membrane protein HopC/AlpA
DNA Sequence 
>gi|210134201:962719-964275 Helicobacter pylori P12 chromosome, complete genome
CATGATAAAGAAAAATGGAACGCTGTTTCTTAGTCTAGCCCTTTGTGCTAGCATAAGTTATGCCGAAGAT
GATGGAGGGTTTTTCACCGTCGGTTATCAGCTTGGGCAAGTCATGCAAGATGTCCAAAACCCAGGTGGCG
CTAAAAGCGACGAACTCGCCAGAGAGCTTAACGCTGATGTAACGAACAACATTTTAAACAACAACACCGG
AGGCAATGTCGCAGGGGCGTTGAGTAACGCTTTCTCCCAATACCTTTATTCGCTTTTAGGGGCGTATCCC
ACGAAACTCAATAGTAACGATGTGTCTGCGAACGCTCTTTTAAGTGGTGCGGTAGGCTCTGGGACTTGCG
CGGCTGCAGGGACGGCTGGTGGCTCAACTCTTAACACTCAAAGCGCTTGCACCGCTGCGGGCTATTACTG
GCTCCCTAGCTTGACTGACAGGATTTTAAGCACGATCGGCAGCCAGACTAACTACGGCACGAACACCAAT
TTCCCCAACATGCAACAACAGCTCACCTACTTGAACGCGGGGAATGTGTTTTTTAATGCGATGAATAAGG
CTTTAGAGAAGAATGGAACTACTAATGGTGCTAGTGGAACTAATGGTGCGACTGGTTCAGATGGTCAAAC
TTACTCTCAACAAGCCATCCAATACCTTCAAGGCCAACAAAATATTCTCAATAACGCAGCGAACTTGCTC
AAGCAAGATGAATTGCTCTTAGAAGCTTTCAACTCTGCTGTAGCCGCCAACATTGGGAATAAGGAATTCA
ATTCGGCCGCTTTTACAGGTTTGGTGCAAGGCATTATTGATCAATCTCAATTGGTTTATAACGAGCTCAC
TAAAAACACCATTAGCGGGAGCGCGGTTAATAGCGCTGGGATAAACTCCAACCAAGCTAACGCTGTGCAA
GGGCGCGCTAGTCAGCTCCCTAACGCTCTTTATAACGCGCAAGTAACTTTGGATAAAATCAATGCGCTCA
ACAATCAAGTGAGAAGCATGCCTTACTTGCCCCAATTCAGAGCCGGGAACAGCCGTTCAACGAATATTTT
GAACGGGTTTTACACCAAAATAGGCTATAAGCAATTCTTCGGGAAGAAAAGGAATATCGGTTTGCGCTAT
TATGGTTTCTTTTCTTATAACGGAGCGAGCGTGGGCTTTAGATCCACTCAAAATAATGTAGGGTTATACA
CTTATGGGGTGGGGACTGATGTGTTGTATAACATCTTTAGCCGCTCCTATCAAAACCGCTCTGTGGATAT
GGGCTTTTTTAGCGGTATCCAATTAGCCGGTGAGACCTTCCAATCCACGCTCAGAGATGATCCCAATGTG
AAATTGCATGGGAAAATCAATAACACGCACTTCCAGTTTCTCTTTGACTTCGGTATGAGGATGAACTTCG
GTAAGTTGGACGGGAAATCCAACCGCCACAACCAGCACACGGTGGAATTTGGCGTAGTGGTGCCTACGAT
TTATAACACTTATTACAAATCCGCAGGGACTACCGTGAAGTATTTCCGTCCTTATAGCGTTTATTGGTCT
TATGGGTATTCATTCTA
Protein Sequence 
>gi|210135103|ref|YP_002301542.1| outer membrane protein HopC/AlpA [Helicobacter pylori P12] MIKKNGTLFLSLALCASISYAEDDGGFFTVGYQLGQVMQDVQNPGGAKSDELARELNADVTNNILNNNTGGNVAGALSNAFSQYLYSLLGAYPTKLNSNDVSANALLSGAVGSGTCAAAGTAGGSTLNTQSACTAAGYYWLPSLTDRILSTIGSQTNYGTNTNFPNMQQQLTYLNAGNVFFNAMNKALEKNGTTNGASGTNGATGSDGQTYSQQAIQYLQGQQNILNNAANLLKQDELLLEAFNSAVAANIGNKEFNSAAFTGLVQGIIDQSQLVYNELTKNTISGSAVNSAGINSNQANAVQGRASQLPNALYNAQVTLDKINALNNQVRSMPYLPQFRAGNSRSTNILNGFYTKIGYKQFFGKKRNIGLRYYGFFSYNGASVGFRSTQNNVGLYTYGVGTDVLYNIFSRSYQNRSVDMGFFSGIQLAGETFQSTLRDDPNVKLHGKINNTHFQFLFDFGMRMNFGKLDGKSNRHNQHTVEFGVVVPTIYNTYYKSAGTTVKYFRPYSVYWSYGYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant showed severe reduction in ability to bind to gastric cell line (Odenbreit et al., 1999).
References
Odenbreit et al., 1999: Odenbreit S, Till M, Hofreuter D, Faller G, Haas R. Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue. Molecular microbiology. 1999; 31(5); 1537-1548. [PubMed: 10200971].