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vacA

Victor ID 3379
Gene Name vacA
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 7010020
NCBI Protein GI 210135077
Locus Tag HPP12_0884
Protein Accession YP_002301516.1
Other Database IDs UniProtKB-ID: B6JMA8_HELP2
UniRef100: UniRef100_B6JMA8
UniRef90: UniRef90_Q48247
UniRef50: UniRef50_Q9ZKW5
UniParc: UPI000183364B
EMBL: CP001217
EMBL-CDS: ACJ08036.1
RefSeq_NT: NC_011498.1
GenomeReviews: CP001217_GR
KEGG: hpp:HPP12_0884
HOGENOM: HBG501852
ProtClustDB: CLSK477705
Taxonomy ID 570508
Gene Starting Position 936185
Gene Ending Position 940075
Gene Strand (Orientation) +
Protein Name vacuolating cytotoxin VacA
DNA Sequence 
>gi|210134201:936185-940075 Helicobacter pylori P12 chromosome, complete genome
AATGGAAATACAACAAACACACCGCAAAATCAATCGCCCTCTGGTTTCTCTCGCTTTAGTAGGAGCATTG
GTCAGCATCACACCGCAACAAAGTCATGCCGCCTTTTTCACAACCGTAATCATTCCAGCCATTGTTGGGG
GTATCGCTTCAGGCGCTGCTGTAGGAACGGTCTCAGGGCTTCTTGGCTGGGGGCTAAAACAAGCCGAAGA
AGCCAATAAAACCCCAGATAAACCCGATAAAGTTTGGCGCATTCAAGCAGGAAAAGGCTTTAATGAATTC
CCTAACAAGGAATACGACTTATACAGATCCCTTTTATCCAGTAAGATTGATGGAGGTTGGGATTGGGGGA
ATGCCGCTACGCATTATTGGGTCAAAGGCGGGCAATGGAACAAGCTTGAAGTGGATATGAAAGACGCTGT
AGGGACTTATAACCTCTCAGGGCTTAGAAACTTTACTGGTGGGGATTTGGATGTCAATATGCAAAAAGCC
ACTTTACGCTTGGGCCAATTCAATGGCAATTCTTTTACAAGCTATAAGGATAGCGCTGATCGCACCACGA
GAGTGGATTTCAACGCTAAAAATATCTCAATTGATAATTTTTTAGAAATCAATAATCGTGTGGGTTCTGG
AGCCGGGAGGAAAGCCAGCTCTACGGTTTTAACTTTGCAAGCTTCAGAAGGGATCACTAGCAGTAAAAAC
GCTGAAATTTCTCTTTATGATGGCGCCACGCTCAATTTGGCTTCAAGCAGCGTTAAATTAATGGGTAATG
TGTGGATGGGCCGTTTGCAATATGTGGGAGCGTATCTGGCCCCTTCATACAGCACGATAAACACTTCAAA
AGTGACAGGGGAAGTGAATTTTAACCATCTCACTGTGGGTGATAGAAACGCCGCTCAAGCAGGCATTATC
GCTAGCAACAAGACTCATATTGGCACACTGGATTTGTGGCAAAGCGCCGGGTTAAACATTATCGCTCCTC
CAGAAGGTGGCTATAAGGATAAACCCAATAATACCCCTTCTCAAAGTGGCGCTAAAAACGACAAAAATGA
AAGCGCCAAAAACGACAAACAAGAGAGCAGTCAAAATAATAGTAACACTCAGGTCATTAACCCACCCAAT
AGCGCGCAAAAAACAGAAGTTCAACCCACGCAAGTCATTGATGGGCCTTTTGCTGGCGGCAAAGACACGG
TGGTCAATATCAACCGCATCAACACTAACGCTGATGGCACGATTAGAGTGGGAGGGTATAAAGCTTCTCT
TACCACCAATGCGGCTCATTTGCATATCGGCAAAGGCGGTGTCAATCTGTCCAATCAAGCGAGCGGGCGC
ACCCTTTTAGTGGAAAATCTAACCGGGAATATCACCGTTGATGGGCCTTTAAGAGTGAATAATCAAGTGG
GTGGTTATGCTTTGGCAGGCTCAAGCGCGAATTTTGAGTTTAAGGCTGGTACGGATACCAAAAACGGCAC
AGCCACTTTTAATAACGATATTAGTTTGGGAAGATTTGTGAATTTAAAAGTGGATGCTCATACAGCTAAT
TTTAAAGGTATTGATACTGGTAATGGTGGTTTCAACACCTTAGATTTTAGTGGCGTTACAGACAAAGTCA
ATATCAACAAGCTCATTACAGCTTCCACTAATGTGGCCATTAAAAACTTCAACATTAATGAATTGTTGGT
TAAGACCAATGGGGTGAGTGTGGGGGAATACACTCATTTTAGCGAAGATATAGGCAGTCAATCGCGCATC
AACACCGTGCGTTTAGAAACTGGCACTAGGTCAATCTTTTCTGGCGGTGTTAAATTTAAAGGCGGTGAAA
AACTGGTTATCAATGATTTTTACTACGCCCCTTGGAATTATTTTGACGCTAGAAACATTAAAAATGTTGA
AATCACCAATAAACTTGCTTTTGGACCTCAAGGAAGCCCTTGGGGTACATCAAAACTTATGTTCAATAAT
CTAACCCTAGGTCAAAATGCGGTCATGGACTATAGCCAATTTTCAAATTTAACCATTCAAGGGGATTTTG
TCAACAATCAAGGCACTATCAATTATTTGGTCCGAGGCGGGCAAGTAGCCACCTTGAATGTAGGCAATGC
AGCGGCTATGTTCTTTAATAATAATGTGGATAGTGCGACTGGGTTTTACCAACCGCTCATGAAGATTAAC
AGCGCTCAAGATCTCATTAAAAATAAAGAACATGTCTTATTGAAAGCGAAAATCATCGGTTATGGCAATG
TTTCTGCGGGCACTAACAGCATTAGTAATGTTAATCTAATAGAGCAATTCAAAGAGCGCCTAGCCCTTTA
TGAACACAACAACCGCATGGATATTTGTGTGGTGCGAAATACTGATGATATTAAAGCATGCGGGACGGCT
ATCGGCAATCAAAGCATGGTGAATAACCCTGACAATTACAAGTATCTTATCGGTAAGGCATGGAAAAATA
TAGGGATCAGCAAAACGGCTAACGGCTCTAAAATTTCGGTGCATTATTTAGGCAATTCTACGCCTACTGA
GAATAGTGGCAATACCACAAATTTACCTACAAACACCACTAGCAATGCGCGTTCTGCCAAAAACGCCCTT
GCGCAAAACGCTCCCTTCGCTCAACCTAGCGCCACTCCTAGTTTAGTCGCTATCAATCAGCATGATTTTG
GCACCATTGAAAGCGTGTTTGAATTGGCTAACCGCTCTAAAGATATTGACACGCTTTATACTCATTCAGG
CGCACAAGGCAGGAATCTCTTACAAACCTTATTGATTGATAGCCATGATGCGGGTTATGCCAGACAAATG
ATTGATAACACAAGCACCGGTGAAATCATCAAGCAATTGAATGCAGCCACTACCACTTTAAACAATGTAG
CTAGTTTAGAGCATAAACAAAGCGGCTTACAAACTTTGAGCTTGAGTAATGCGATGATTTTAAATTCTCG
TTTAGTCAATCTCTCCAGAAGGCACACCAACAATATTGACTCGTTCGCCCAACGCTTGCAAGCTTTAAAA
GACCAAAAATTCGCTTCTTTAGAAAGCGCAGCAGAAGTGTTGTATCAATTTGCTCCTAAATATGAAAAAC
CCACCAATGTTTGGGCTAACGCTATTGGAGGAACAAGCTTGAATAATGGCGGCAACGCTTCATTGTATGG
CACAAGCGCCGGCGTAGACGCTTACCTTAACGGGGAAGTGGAAGCCATTGTGGGCGGTTTTGGAAGCTAT
GGTTATAGCTCCTTTAGTAATCAAGCGAACTCCCTTAACTCTGGAGCCAATAACACTAATTTTGGCGTGT
ATAGCCGTCTCTTTGCTAACCAGCATGAATTTGACTTTGAAGCTCAAGGGGCGCTAGGGAGTGATCAATC
AAGCTTGAATTTCAAAAGCGCTTTATTGCGAGATTTGAATCAAAGCTATAATTACTTAGCCTATAGCGCT
GCAACAAGAGCGAGCTATGGTTATGACTTCGCGTTTTTTAGGAACGCTTTAGTGTTAAAACCAAGCGTGG
GTGTGAGCTATAACCATTTAGGTTCAACCAACTTTAAAAGCAACAGCACCAATCAAGTGGCTTTGAAAAA
TGGCTCTAGCAGTCAGCATTTATTCAACGCTAGCGCTAATGTAGAAGCGCGCTATTATTATGGGGACACT
TCATACTTCTATATGAACGCTGGAGTTTTACAAGAATTCGCTAACTTTGGTTCTAGCAATGCGGTGTCTT
TAAACACCTTTAAAGTGAATGCCGCTCGCAACCCTTTAAATACCCATGCCAGAGTGATGATGGGTGGGGA
ATTAAAATTAGCTAAAGAAGTGTTTTTGAATTTGGGCTTTGTTTATTTGCACAATTTGATTTCCAATATA
GGCCATTTCGCTTCCAATTTAGGAATGAGGTATAGTTTCTA
Protein Sequence 
>gi|210135077|ref|YP_002301516.1| vacuolating cytotoxin VacA [Helicobacter pylori P12] MEIQQTHRKINRPLVSLALVGALVSITPQQSHAAFFTTVIIPAIVGGIASGAAVGTVSGLLGWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYRSLLSSKIDGGWDWGNAATHYWVKGGQWNKLEVDMKDAVGTYNLSGLRNFTGGDLDVNMQKATLRLGQFNGNSFTSYKDSADRTTRVDFNAKNISIDNFLEINNRVGSGAGRKASSTVLTLQASEGITSSKNAEISLYDGATLNLASSSVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFNHLTVGDRNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNNTPSQSGAKNDKNESAKNDKQESSQNNSNTQVINPPNSAQKTEVQPTQVIDGPFAGGKDTVVNINRINTNADGTIRVGGYKASLTTNAAHLHIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVGGYALAGSSANFEFKAGTDTKNGTATFNNDISLGRFVNLKVDAHTANFKGIDTGNGGFNTLDFSGVTDKVNINKLITASTNVAIKNFNINELLVKTNGVSVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKGGEKLVINDFYYAPWNYFDARNIKNVEITNKLAFGPQGSPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFVNNQGTINYLVRGGQVATLNVGNAAAMFFNNNVDSATGFYQPLMKINSAQDLIKNKEHVLLKAKIIGYGNVSAGTNSISNVNLIEQFKERLALYEHNNRMDICVVRNTDDIKACGTAIGNQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVHYLGNSTPTENSGNTTNLPTNTTSNARSAKNALAQNAPFAQPSATPSLVAINQHDFGTIESVFELANRSKDIDTLYTHSGAQGRNLLQTLLIDSHDAGYARQMIDNTSTGEIIKQLNAATTTLNNVASLEHKQSGLQTLSLSNAMILNSRLVNLSRRHTNNIDSFAQRLQALKDQKFASLESAAEVLYQFAPKYEKPTNVWANAIGGTSLNNGGNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNQANSLNSGANNTNFGVYSRLFANQHEFDFEAQGALGSDQSSLNFKSALLRDLNQSYNYLAYSAATRASYGYDFAFFRNALVLKPSVGVSYNHLGSTNFKSNSTNQVALKNGSSSQHLFNASANVEARYYYGDTSYFYMNAGVLQEFANFGSSNAVSLNTFKVNAARNPLNTHARVMMGGELKLAKEVFLNLGFVYLHNLISNIGHFASNLGMRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: knockout did not cause gastric ulcers in mice compared to wild type (Isomoto et al., 2010).
References
Isomoto et al., 2010: Isomoto H, Moss J, Hirayama T. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. The Tohoku journal of experimental medicine. 2010; 220(1); 3-14. [PubMed: 20046046].