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cagA

Victor ID 396
Gene Name cagA
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 889201
NCBI Protein GI 15611562
Locus Tag jhp0495
Protein Accession NP_223213.1
Other Database IDs UniProtKB-ID: CAGA_HELPJ
UniRef100: UniRef100_Q9ZLT1
UniRef90: UniRef90_Q9ZLT1
UniRef50: UniRef50_Q9ZLT1
UniParc: UPI0000126DD7
EMBL: AE001439
EMBL-CDS: AAD06073.1
RefSeq_NT: NC_000921.1
GenomeReviews: AE001439_GR
KEGG: hpj:jhp0495
NMPDR: fig|85963.1.peg.491
HOGENOM: HBG501747
OMA: LKRHDKV
ProtClustDB: CLSK477505
BioCyc: HPYL85963:JHP0495-MONOMER
Taxonomy ID 85963
Gene Starting Position 543604
Gene Ending Position 547107
Gene Strand (Orientation) +
Protein Name cag island protein, CYTOTOXICITY ASSOCIATED IMMUNODOMINANT ANTIGEN
DNA Sequence 
>gi|15611071:543604-547107 Helicobacter pylori J99, complete genome
AATGACTAACGAAGCCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAAT
AATCTTCAAGTGGCTTTTATTAAAGTTGATAATGTTGTCGCTTCATTTGATCCTAATCAAAAACCAATCG
TTGATAAGAATGATAGGGATAATAGGCAAGCTTTTGAGAAAATCTCGCAGCTAAGGGAGGAATTCGCTAA
TAAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAAGCTTTATCAGTAAGAGCAATGATTTA
ATCGACAAAGACAATCTCATTGATACAGGTTCTTCCATAAAGAGCTTTCAGAAATTTGGGACTCAGCGTT
ACCAAATTTTTATGAATTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCAAAAAATCCGAGG
TTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTGAGGTCTGCC
AAACAAGCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTG
ATGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGAGATCCTACTGGTGGGGA
TTGGCTTGATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAAT
CAAGAACCAGTTCCTCATGTCCAACCAGATGTAGCCACTACCACCACTGACATACAAAGCTTACCGCCTG
AAGCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGAACATGTTAGA
TGTTGAGGGAGTCGCTGACATTGATCCTAATTACAAGTTCAACCAATTATTGATCCACAATAACGCTCTG
TCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTGTTGTATGGAAACAATG
GTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACGAGGCGACAATGTGGC
TACACTCATTAATGTGCATATGAAAAATGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGATTAAC
AACCCTAGTTTTTATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGA
TCCAAAACAAAGTGGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGAA
AGAGAAAGAAAAATTCCAAAATGAGATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTA
GGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACAAAAAACATTTAGCTTTAGTTGCTGAGTTTGGTA
ATGGGGAATTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGGCAAA
AACCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACC
AACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTA
GCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTGTCGTAAGGCAGGATTT
AGAGGATAAACTAATCGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTTGTCAAAGATTTTTTGAGC
AGCAACAAAGAATTGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCA
ACTATGACGAGGTGAAACAAGCTCAGAAAGATCTTGAAAAATCTCTAAAGAAACGAGAGCGTTTGGAGAA
AGATGTAGCGAAAAATTTGGAGAGCAAAAGCGGCAACAAAAATAAAATGGAAGCAAAATCTCAAGCTAAC
AGCCAAAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGATGCAAGAGCAATCGCTTACG
CTCAGAATCTTAAAGGCATCAAAAGGGAATTGTCTGATAAACTTGAAAATATCAACAAGGATTTGAAAGA
CTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACACTA
AAAGCCCTTAAAGGCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTA
ATGCAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGA
CCTTGAAAATTCCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGATAATCTCAATCAA
GCGGTATCAGTGGCTAAAGCAACGGGTGATTTCAGTGGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATT
TCTCAAAGGAGCAATTGGCTCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGCACT
ATACCAATCCGTTAAGAATGGTGTAAACGGAACCCTAGTCGGTAATGGGTTATCTAAAGCAGAAGCCACA
ACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTGGAAATTTCAATAACAATA
ACAATAATGGACTCGAAAACAGCACAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAAAGCAAAAAT
TGACCGACTCGATCAAATAGCAAGTGGTTTGGGTGATGTAGGGCAAGCAGCGAGCTTCCTTTTGAAAAGG
CATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAGCTAACCATGAACCCATTTACGCTACGATTG
ATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTC
AAGGGAGCAAAAATTGACTCAGAAAATTGACAATCTCAACCAGGCGGTATCAGAAGCTAAAGCAAGTCAT
TTTGACAACCTAGATCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATATG
TTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAATTGGACAATTACGCTACTAACAGCCACAC
ACGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAAT
TCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGTGCTCCTTTGTCAGCGT
ATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAGGTT
GAGCAATGCCGTAAAAGACATTAAGTCTGGCTTTGTGCAATTTTTAACCAATATATTTTCTATGGGATCT
TACAGCTTGATGAAAGCAAGTGTGGAACATGGAGTCAAAAATACTAATACAAAAGGTGGTTTCCAAAAAT
CTTA
Protein Sequence 
>gi|15611562|ref|NP_223213.1| cag island protein, cytotoxicity associated immunodominant antigen [Helicobacter pylori J99] MTNEAINQQPQTEAAFNPQQFINNLQVAFIKVDNVVASFDPNQKPIVDKNDRDNRQAFEKISQLREEFANKAIKNPTKKNQYFSSFISKSNDLIDKDNLIDTGSSIKSFQKFGTQRYQIFMNWVSHQNDPSKINTQKIRGFMENIIQPPISDDKEKAEFLRSAKQAFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPVPHVQPDVATTTTDIQSLPPEARDLLDERGNFSKFTLGDMNMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYGNNGGPEARHDWNATVGYKNQRGDNVATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKVDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKKADKALDREAKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEAGFSKVAVFNLPNLNNLAITSVVRQDLEDKLIAKGLSPQEANKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKDVAKNLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENINKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKATGDFSGVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLENSTEPIYTQVAKKVKAKIDRLDQIASGLGDVGQAASFLLKRHDKVDDLSKVGLSANHEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSREQKLTQKIDNLNQAVSEAKASHFDNLDQMIDKLKDSTKKNVVNLYVESAKKVPTSLSAKLDNYATNSHTRINSNVKNGTINEKATGMLTQKNSEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNIFSMGSYSLMKASVEHGVKNTNTKGGFQKS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in monkeys (Hornsby et al., 2008).
References
Hornsby et al., 2008: Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner. Gastroenterology. 2008; 134(4); 1049-1057. [PubMed: 18395086].