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alpB

Victor ID 3382
Gene Name alpB
Sequence Strain (Species/Organism) Helicobacter
NCBI Gene ID 7010049
NCBI Protein GI 210135104
Locus Tag HPP12_0911
Protein Accession YP_002301543.1
Other Database IDs UniProtKB-ID: B6JMD5_HELP2
UniRef100: UniRef100_B6JMD5
UniRef90: UniRef90_E1Q024
UniRef50: UniRef50_E1Q024
UniParc: UPI00018336EB
EMBL: CP001217
EMBL-CDS: ACJ08063.1
RefSeq_NT: NC_011498.1
GenomeReviews: CP001217_GR
KEGG: hpp:HPP12_0911
HOGENOM: HBG501865
ProtClustDB: CLSK496273
Taxonomy ID 570508
Gene Starting Position 964297
Gene Ending Position 965886
Gene Strand (Orientation) +
Protein Name outer membrane protein HopB/AlpB
DNA Sequence 
>gi|210134201:964297-965886 Helicobacter pylori P12 chromosome, complete genome
CATGAAACAAAATTTAAAGCCATTCAAAATGATTAAGGAAAATTTAATGACACAATCTCAAAAAGTAAGA
TTCTTAGCCCCTTTAAGCCTAGCGTTAAGCTTGAGCTTCAATCCAGTGGGCGCTGAAGAAGATGGGGGCT
TTATGACCTTTGGGTATGAATTAGGTCAGGTGGTCCAACAAGTGAAAAACCCGGGTAAAATCAAAGCCGA
AGAATTAGCCGGCTTGTTAAACTCTAACACGACAAACAACACCAATATCAATATTGCAGGCACAGGAGGC
AATGTCGCCGGGACTTTGGGCAACCTCTTTATGAACCAATTAGGCAATTTGATTAATTTGTATCCCACTT
TGAACACTGGCAGTATCCATCAATGTGGTGCTACTAATAATGGTGGTGGTGGTGGTGTGACCGCAGCCGC
TACTACTAGCAATAGCCCTTGTTTCCAAGGTAACCTGGCTCTTTATAACGAAATGGTTGGCTCTATCAAA
ACTTTGAGTCAAAACATCAGCAAGAATATCTTTCAAGGCAACAACAACACCACGAGCCAAAATCTCTCCA
ACCAGCTCAGTGAGCTTAACACCGCTAGCGTTTATTTGACTTACATGAACTCGTTCTTAAACGCCAATAA
CCAAGCGGGTGGGATCTTTCAAAATAACACTAATCAAGTTTATGGAAGTGGTGTTACCGCCCAACAAATC
GCTTATGTCCTAAAGCAAGCTTCAATCACTATGGGGCCAAGCGGTGATAGCGGGGCTGCCGCAGCGTTTT
TGGACGCCGCTTTAGCGCAACATGTTTTCAACTCCGCTAACGCCGGGAATGATTTGAGTGCTAAGGAATT
CACTAGCTTGGTGCAAAACATCGTCAATAATTCTCAAAACGCTTTAACGCTAGCCAACAACGCTAACATC
AGCAATTCAACCGGCTATCAAGTGAGCTATGGCGGGAATATTGATCAAGCGCGCTCTACCCAACTGTTAA
ACAACACCACAAACACTTTGGCTAAAGTTACCGCTTTGAATAACGAGCTTAAAGCTAACCCATGGCTTGG
GAATTTCGCTGCCGGTAACAGCTCTCAAGTGAATGCGTTTAACGGGTTTATCACTAAAATCGGTTATAAG
CAATTCTTCGGAGAAAACAAGAATGTGGGCTTACGCTACTACGGCTTCTTCAGCTATAATGGCGCGGGCG
TGGGTAATGGCCCCACTTACAATCAAGTCAATTTGCTCACTTATGGGGTGGGGACTGATGTGCTTTACAA
TGTGTTTAGCCGCTCTTTTGGTAGCCGAAGTCTTAATGCGGGCTTCTTTGGGGGGATCCAACTTGCAGGG
GACACTTACATCAGCACGCTAAGAAACAGCCCTCAGCTTGCGAGCAGACCTACAGCGACAAAATTCCAAT
TCTTGTTTGATGTGGGCTTACGCATGAACTTTGGTATCTTGAAAAAAGACCTAAAAAGCCACAACCAGCA
TTCTATAGAAATCGGTGTGCAAATCCCTACGATTTATAACACTTATTATAAAGCTGGCGGCGCTGAAGTG
AAATACTTCCGCCCTTATAGCGTGTATTGGGTCTATGGCTACGCCTTCTA
Protein Sequence 
>gi|210135104|ref|YP_002301543.1| outer membrane protein HopB/AlpB [Helicobacter pylori P12] MKQNLKPFKMIKENLMTQSQKVRFLAPLSLALSLSFNPVGAEEDGGFMTFGYELGQVVQQVKNPGKIKAEELAGLLNSNTTNNTNINIAGTGGNVAGTLGNLFMNQLGNLINLYPTLNTGSIHQCGATNNGGGGGVTAAATTSNSPCFQGNLALYNEMVGSIKTLSQNISKNIFQGNNNTTSQNLSNQLSELNTASVYLTYMNSFLNANNQAGGIFQNNTNQVYGSGVTAQQIAYVLKQASITMGPSGDSGAAAAFLDAALAQHVFNSANAGNDLSAKEFTSLVQNIVNNSQNALTLANNANISNSTGYQVSYGGNIDQARSTQLLNNTTNTLAKVTALNNELKANPWLGNFAAGNSSQVNAFNGFITKIGYKQFFGENKNVGLRYYGFFSYNGAGVGNGPTYNQVNLLTYGVGTDVLYNVFSRSFGSRSLNAGFFGGIQLAGDTYISTLRNSPQLASRPTATKFQFLFDVGLRMNFGILKKDLKSHNQHSIEIGVQIPTIYNTYYKAGGAEVKYFRPYSVYWVYGYAF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant showed severe reduction in ability to bind to gastric cell line (Odenbreit et al., 1999).
References
Odenbreit et al., 1999: Odenbreit S, Till M, Hofreuter D, Faller G, Haas R. Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue. Molecular microbiology. 1999; 31(5); 1537-1548. [PubMed: 10200971].