| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
ompP2 from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3429565
|
|
68248747
|
NTHI0225 |
|
YP_247859.1 |
OMP P2 |
Virulence factor |
MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels [Ref6736:Sanders et al., 1993]. P2 mutants are unable to produce detectable bacteremia in infant rats [Ref6737:Cope et al., 1990]. |
7689543
2169463
|
|
|
dam from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3429634
|
|
68248814
|
NTHI0307 |
|
YP_247926.1 |
deoxyadenosyl-methyltransferase; DNA adenine methyltransferase; M.HindIV |
Virulence factor |
MUTATION: dam mutants is attenuated in invasion of of human brain microvascular endothelial cells (HBMECs) and human respiratory epithelial cells (NCI-H292) [Ref6738:Watson et al., 2004]. |
15228541
|
|
|
lgtC |
Haemophilus influenzae 86-028NP |
3429690
|
|
68248865
|
NTHI0365 |
CP000057 |
YP_247977 |
UDP-galactose--lipooligosaccharide galactosyltransferase |
Virulence factor |
MUTATION: lgtC mutant is attenuated in infant rat model [Ref6739:Hood et al., 1996]. |
8855319
|
|
|
oapA from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3429769
|
|
68248935
|
NTHI0448 |
|
YP_248047.1 |
opacity associated protein OapA |
Virulence factor |
MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type [Ref6740:Prasadarao et al., 1999]. |
10417187
|
|
|
lic3A |
Haemophilus influenzae 86-028NP |
3429791
|
|
68248957
|
NTHI0472 |
CP000057 |
YP_248069 |
CMP-Neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase |
Virulence factor |
MUTATION: lic3A mutant is attenuated in chinchilla [Ref6741:Bouchet et al., 2003]. |
12855765
|
|
|
accA from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3429845
|
|
68249008
|
NTHI0528 |
|
YP_248120.1 |
acetyl-CoA carboxylase carboxyltransferase subunit alpha |
Virulence factor |
MUTATION: accA mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
rpoE from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3430027
|
|
68249183
|
NTHI0719 |
|
YP_248295.1 |
Sigma-24 |
Virulence factor |
MUTATION: ropE mutants are unable to survive intracellularly in macrophages [Ref6743:Craig et al., 2002]. |
11796603
|
|
|
pgmB |
Haemophilus influenzae 86-028NP |
3430211
|
|
68249340
|
NTHI0899 |
CP000057 |
YP_248452 |
phosphoglucomutase |
Virulence factor |
MUTATION: pgmB mutant is had reduced adherence and invasion of human bronchial epithelial cells (16HBE14) [Ref6744:Swords et al., 2000]. |
10931302
|
|
|
dsbA from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3430315
|
|
68249440
|
NTHI1012 |
|
YP_248552.1 |
thiol:disulfide interchange protein DsbA |
Virulence factor |
MUTATION: dsbA mutant is attenuated in mice [Ref6745:Rosadini et al., 2008]. |
18212083
|
|
|
hbpA |
Haemophilus influenzae 86-028NP |
3430322
|
|
68249447
|
NTHI1021 |
CP000057 |
YP_248559 |
heme-binding protein A |
Virulence factor |
MUTATION: hbpA mutant is attenuated in mice [Ref6745:Rosadini et al., 2008]. |
18212083
|
|
|
hktE from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3430392
|
|
68249515
|
NTHI1099 |
|
YP_248627.1 |
catalase |
Virulence factor |
MUTATION: ktkE mutant has attenuated virulence in interperitoneal infection in infant rats [Ref6746:Bishai et al., 1994]. |
7927766
|
|
|
licD |
Haemophilus influenzae 86-028NP |
3430833
|
|
68249945
|
NTHI1594 |
CP000057 |
YP_249057 |
phosphorylcholine transferase |
Virulence factor |
MUTATION: licD mutant is more rapidly cleared in mouse pulmonary infection than the wild type [Ref6747:Pang et al., 2008]. |
18347044
|
|
|
siaB |
Haemophilus influenzae 86-028NP |
3431148
|
|
68250197
|
NTHI1891 |
CP000057 |
YP_249309 |
acylneuraminate cytidylyltransferase |
Virulence factor |
MUTATION: siaB mutant is attenuated in chinchillas [Ref6741:Bouchet et al., 2003]. |
12855765
|
|
|
tehB from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3431152
|
|
68250201
|
NTHI1895 |
|
YP_249313.1 |
tellurite resistance protein TehB |
Virulence factor |
MUTATION: tehB mutant is attenuated in rats [Ref6748:Whitby et al., 2010]. |
20075041
|
|
|
ptsI from Haemophilus influenzae 86-028NP |
Haemophilus influenzae 86-028NP |
3431268
|
|
68250314
|
NTHI2021 |
|
YP_249426.1 |
phosphotransferase system, enzyme I |
Virulence factor |
MUTATION: ptsI is attenuated in mice [Ref6749:Kok et al., 2003]. |
12949188
|
|
|
HI0364 |
Haemophilus influenzae Rd KW20 |
949374
|
|
16272312
|
HI0364 |
L42023 |
NP_438525 |
penicillin-binding protein 7 |
Virulence factor |
MUTATION: HI0364 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
oapA from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
949442
|
|
16272282
|
HI0330 |
|
NP_438494.1 |
opacity associated protein |
Virulence factor |
MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type [Ref6740:Prasadarao et al., 1999]. |
10417187
|
|
|
HI1018 |
Haemophilus influenzae Rd KW20 |
949460
|
|
0
|
HI1018 |
|
- |
pseudo |
Virulence factor |
MUTATION: HI1018 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
accA from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
949505
|
|
16272355
|
HI0406 |
|
NP_438568.1 |
acetyl-CoA carboxylase carboxyltransferase subunit alpha |
Virulence factor |
MUTATION: accA mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
nudC |
Haemophilus influenzae Rd KW20 |
949531
|
|
16272380
|
HI0432 |
L42023 |
NP_438593 |
NADH pyrophosphatase |
Virulence factor |
MUTATION: nudC mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI1245 |
Haemophilus influenzae Rd KW20 |
949562
|
|
16273164
|
HI1245 |
L42023 |
NP_439401 |
malic enzyme |
Virulence factor |
MUTATION: HI1245 mutant is attenuated in rats [Ref6742:Herbert et al., 2002] |
12473436
|
|
|
fdx-2 |
Haemophilus influenzae Rd KW20 |
949590
|
|
16272471
|
HI0527 |
L42023 |
NP_438685 |
ferredoxin |
Virulence factor |
MUTATION: fdx-2 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
oapA from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
949701
|
|
16272604
|
HI0661 |
|
NP_438821.1 |
hemoglobin-binding protein |
Virulence factor |
MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type [Ref6740:Prasadarao et al., 1999]. |
10417187
|
|
|
HI0700 |
Haemophilus influenzae Rd KW20 |
949725
|
|
16272641
|
HI0700 |
L42023 |
NP_438859 |
hypothetical protein |
Virulence factor |
MUTATION: HI0700 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
arcA |
Haemophilus influenzae Rd KW20 |
949839
|
|
16272824
|
HI0884 |
L42023 |
NP_439045 |
two-component response regulator |
Virulence factor |
MUTATION: arcA mutant is attenuated in mice [Ref6750:De et al., 2003]. |
12496162
|
|
|
obgE |
Haemophilus influenzae Rd KW20 |
949885
|
|
16272817
|
HI0877 |
L42023 |
NP_439038 |
GTPase ObgE |
Virulence factor |
MUTATION: obgE mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
emrA |
Haemophilus influenzae Rd KW20 |
949904
|
|
16272836
|
HI0898 |
L42023 |
NP_439059 |
multidrug resistance protein A |
Virulence factor |
MUTATION: emrA mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
hktE from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
949926
|
|
16272865
|
HI0928 |
|
NP_439088.1 |
catalase |
Virulence factor |
MUTATION: htkE mutant has attenuated virulence in interperitioneal infection of infant rats [Ref6746:Bishai et al., 1994]. |
7927766
|
|
|
tehB from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
949980
|
|
16273190
|
HI1275 |
|
NP_439428.1 |
tellurite resistance protein TehB |
Virulence factor |
MUTATION: tehB mutant is attenuated in rats [Ref6748:Whitby et al., 2010]. |
20075041
|
|
|
pmbA |
Haemophilus influenzae Rd KW20 |
950115
|
|
16273077
|
HI1152 |
L42023 |
NP_439310 |
hypothetical protein |
Virulence factor |
MUTATION: pmbA mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
ompA |
Haemophilus influenzae Rd KW20 |
950124
|
|
16273088
|
HI1164 |
L42023 |
NP_439322 |
outer membrane protein P5 |
Virulence factor |
MUTATION: ompA mutant had reduced adherence to human oropharyngeal cells in vitro, augmented clearance from the tympanum post-transbullar inoculation, and significantly reduced induction of OM post-intranasal inoculation in a chinchilla model compared to the wild type [Ref6751:Sirakova et al., 1994]. |
7909539
|
|
|
dsbA from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
950165
|
|
30995432
|
HI1215 |
|
NP_439371.2 |
thiol-disulfide interchange protein |
Virulence factor |
MUTATION: dsbA mutant is attenuated in mice [Ref6745:Rosadini et al., 2008]. |
18212083
|
|
|
HI0561 |
Haemophilus influenzae Rd KW20 |
950224
|
|
16272504
|
HI0561 |
L42023 |
NP_438718 |
hypothetical protein |
Virulence factor |
MUTATION: HI0561 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI1459 |
Haemophilus influenzae Rd KW20 |
950350
|
|
30995451
|
HI1459 |
L42023 |
NP_439610 |
RNA polymerase sigma factor |
Virulence factor |
MUTATION: HI1459 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
parE |
Haemophilus influenzae Rd KW20 |
950390
|
|
16273428
|
HI1528 |
L42023 |
NP_439677 |
DNA topoisomerase IV subunit B |
Virulence factor |
MUTATION: parE mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
licA |
Haemophilus influenzae Rd KW20 |
950399
|
|
16273437
|
HI1537 |
L42023 |
NP_439686 |
lic-1 operon protein |
Virulence factor |
MUTATION: licA mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI1598 |
Haemophilus influenzae Rd KW20 |
950454
|
|
16273488
|
HI1598 |
L42023 |
NP_439740 |
hypothetical protein |
Virulence factor |
MUTATION: HI1598 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI1368 |
Haemophilus influenzae Rd KW20 |
950673
|
|
16273278
|
HI1368 |
L42023 |
NP_439519 |
putative zinc protease |
Virulence factor |
MUTATION: HI1368 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI0936 |
Haemophilus influenzae Rd KW20 |
950731
|
|
16272873
|
HI0936 |
L42023 |
NP_439096 |
cytochrome C-type biogenesis |
Virulence factor |
MUTATION: HI0936 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
lctP |
Haemophilus influenzae Rd KW20 |
950748
|
|
16273137
|
HI1218 |
L42023 |
NP_439374 |
L-lactate permease |
Virulence factor |
MUTATION: lctP mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
alaS |
Haemophilus influenzae Rd KW20 |
950776
|
|
16272755
|
HI0814 |
L42023 |
NP_438974 |
alanyl-tRNA synthetase |
Virulence factor |
MUTATION: alaS mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
rpoE from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
950801
|
|
16272571
|
HI0628 |
|
NP_438788.1 |
RNA polymerase sigma factor RpoE |
Virulence factor |
MUTATION: ropE mutants are unable to survive intracellularly in macrophages [Ref6743:Craig et al., 2002]. |
11796603
|
|
|
dsbB |
Haemophilus influenzae Rd KW20 |
950809
|
|
16272376
|
HI0428 |
L42023 |
NP_438589 |
disulfide bond formation protein B |
Virulence factor |
MUTATION: dsbB mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
HI1677 |
Haemophilus influenzae Rd KW20 |
950862
|
|
16273564
|
HI1677 |
L42023 |
NP_439819 |
iron-sulfur cluster repair di-iron protein |
Virulence factor |
MUTATION: Compared to the wild-type strain, the ytfE (HI1677) mutant exhibited decreased survival when exposed to macrophages, a defect that was more pronounced after prior stimulation of macrophages with IFN-gamma or lipopolysaccharide. Complementation restored survival of the mutant to the level in the parental strain [Ref6752:Harrington et al., 2009]. |
19289513
|
|
|
ptsI from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
950872
|
|
16273599
|
HI1712 |
|
NP_439854.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsl mutant is attenuated in mice [Ref6749:Kok et al., 2003]. |
12949188
|
|
|
HI1732 |
Haemophilus influenzae Rd KW20 |
950878
|
|
0
|
HI1732 |
|
- |
- |
Virulence factor |
MUTATION: HI1732 mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
metB |
Haemophilus influenzae Rd KW20 |
950982
|
|
16272060
|
HI0086 |
L42023 |
NP_438259 |
cystathionine gamma-synthase |
Virulence factor |
MUTATION: metB mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
afuB |
Haemophilus influenzae Rd KW20 |
951037
|
|
16272097
|
HI0129 |
L42023 |
NP_438299 |
ferric transport system permease-like protein |
Virulence factor |
MUTATION: afuB mutant is attenuated in rats [Ref6742:Herbert et al., 2002]. |
12473436
|
|
|
ompP2 |
Haemophilus influenzae Rd KW20 |
951048
|
|
16272106
|
HI0139 |
L42023 |
NP_438308 |
outer membrane protein P2 |
Virulence factor |
MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels [Ref6736:Sanders et al., 1993]. P2 mutants are unable to produce detectable bacteremia in infant rats [Ref6737:Cope et al., 1990]. |
7689543
2169463
|
|
|
dam from Haemophilus influenzae Rd KW20 |
Haemophilus influenzae Rd KW20 |
951117
|
|
16272172
|
HI0209 |
|
NP_438378.1 |
DNA adenine methylase |
Virulence factor |
MUTATION: dam mutants is attenuated in invasion of of human brain microvascular endothelial cells (HBMECs) and human respiratory epithelial cells (NCI-H292) [Ref6738:Watson et al., 2004]. |
15228541
|
|
|
LPS |
Haemophilus influenzae |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: isogenic sialic acid-deficient LPS mutants (disrupted sialyltransferase or CMP-acetylneuraminic acid synthetase genes) were profoundly attenuated in chinchillas [Ref6741:Bouchet et al., 2003]. |
12855765
|
|
|
type b polysaccharide capsule |
Haemophilus influenzae |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: mutations in the genes hcsA and/or hcsB resulted in diminished polysaccharide b capsule, and were attenuated in neonatal mice [Ref7311:Sukupolvi-Petty et al., 2006]. |
16707679
|
