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lic3A

Victor ID 2831
Gene Name lic3A
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
NCBI Gene ID 3429791
NCBI Protein GI 68248957
Locus Tag NTHI0472
Genbank Accession CP000057
Protein Accession YP_248069
Other Database IDs UniProtKB-ID: Q4QNI8_HAEI8
UniRef100: UniRef100_Q4QNI8
UniRef90: UniRef90_A5UI12
UniRef50: UniRef50_P24324
UniParc: UPI00003CD747
EMBL: CP000057
EMBL-CDS: AAX87409.1
RefSeq_NT: NC_007146.2
GenomeReviews: CP000057_GR
KEGG: hit:NTHI0472
HOGENOM: HBG495027
OMA: KHALKSR
ProtClustDB: CLSK789677
BioCyc: HINF281310:NTHI0472-MONOMER
Taxonomy ID 281310
Gene Starting Position 447633
Gene Ending Position 448595
Gene Strand (Orientation) -
Protein Name CMP-Neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase
Protein pI 9.16
Protein Weight 36896.76
Protein Length 320
Protein Note Similar to: HI0352, Y352_HAEIN
DNA Sequence 
>gi|162960935:447633-448595 Haemophilus influenzae 86-028NP chromosome, complete genome
TCTAATCCCATTTTCTTGATTTTAAGGCGTGTTTTATATCATTAGGTAAACGTAATATATCCCAGAACAA
CCGAAAAATCAGATTTTGGTAAATTCTTGGTTTGGAATATATACCAATTTTTTTATATACAAACTTCGGC
GGAATTAAAATATCTTGTGTGTAATTTTTCTTTTCTTCTGGAATAAAAGCAATTGGGTTATTCAGTGGTG
ATAAAGGAAAATAATTACATAGAGGACTTTCTGGCGAAATGCAATAAATATTTACTCCATAATGTTTTTG
TAAAAAATAAAGTGCATTTAAATCATATTCCATAGAATGGATATCGCTTTGACTTTTATTTTGTGAAAAA
GAAGGTAATAATTTAATAATATTTTCTTTTTGATGATGAAATGCGTAAGGATTCCCTTTTTCTTGATAAA
AATCAATACCTGTTAAATAAAGATCTTTATAACCCATTGCAGTCGCCACTGCACACATATAAACGCCTGA
TGTAATCCTCTTATTCTCATATAATTCGTGATATTGTAAATGAGCATTAAAAGCTCGTAGTTTTTTCAAA
TAGCAATGACCAAGATCAATTTGTGGCAGTAATTTTTCTAAATGCTGGATTTTCTTTAATGTTGAATCCC
CTAAATTCAGAAAAGATGCTAAGATAATATCAGCATATTCATATTTATATTCATTATTTTTAATTAATTG
CATAAACGTATAGTATTGTTCAAAAATTACAGAACAATTAAAAAATACCTTTTTTATTTTCTTGCCAAGA
AAATAATGATCTTCAAAATAAAATTGATTGCAACGGAAAACATCATAATCTTTAGGTAATAAACTATAGT
CAATTGATTTTAAACTTGTTCCATTACCTGCAATAATGACAGACTTTGATTGATTGATTGATTGATTGAT
TGATTGATTGATTGATTGATTGATTGATTGATTGATTGATTGATTGATTGACA
Protein Sequence 
>gi|68248957|ref|YP_248069.1| CMP-Neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase [Haemophilus influenzae 86-028NP]
MSINQSINQSINQSINQSINQSINQSKSVIIAGNGTSLKSIDYSLLPKDYDVFRCNQFYFEDHYFLGKKI
KKVFFNCSVIFEQYYTFMQLIKNNEYKYEYADIILASFLNLGDSTLKKIQHLEKLLPQIDLGHCYLKKLR
AFNAHLQYHELYENKRITSGVYMCAVATAMGYKDLYLTGIDFYQEKGNPYAFHHQKENIIKLLPSFSQNK
SQSDIHSMEYDLNALYFLQKHYGVNIYCISPESPLCNYFPLSPLNNPIAFIPEEKKNYTQDILIPPKFVY
KKIGIYSKPRIYQNLIFRLFWDILRLPNDIKHALKSRKWD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lic3A mutant is attenuated in chinchilla (Bouchet et al., 2003).
References
Bouchet et al., 2003: Bouchet V, Hood DW, Li J, Brisson JR, Randle GA, Martin A, Li Z, Goldstein R, Schweda EK, Pelton SI, Richards JC, Moxon ER. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(15); 8898-8903. [PubMed: 12855765].