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parE

Victor ID 2861
Gene Name parE
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 950390
NCBI Protein GI 16273428
Locus Tag HI1528
Genbank Accession L42023
Protein Accession NP_439677
Other Database IDs UniProtKB-ID: PARE_HAEIN
UniRef100: UniRef100_P43703
UniRef90: UniRef90_P43703
UniRef50: UniRef50_P43703
UniParc: UPI00000512CE
EMBL: L42023
EMBL-CDS: AAC23174.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI1528
NMPDR: fig|71421.1.peg.1455
TIGR: HI_1528
HOGENOM: HBG304889
OMA: QARDKEF
ProtClustDB: PRK05559
BioCyc: HINF71421:HI_1528-MONOMER
Taxonomy ID 71421
Gene Starting Position 1598288
Gene Ending Position 1600186
Gene Strand (Orientation) +
Protein Name DNA topoisomerase IV subunit B
Protein pI 5.86
Protein Weight 65608.45
Protein Length 632
Protein Note decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
DNA Sequence 
>gi|16271976:1598288-1600186 Haemophilus influenzae Rd KW20 chromosome, complete genome
CATGACAACCAATTATTCAGCTCAAGAAATTACCGTTCTTAAAGATCTCGAACCAGTGCAAATTCGCCCG
GGAATGTACACTGACACTACTCGCCCTAATCATTTAGCACAAGAAGTTATTGATAACAGTGTGGATGAAG
CCCTTGCCGGTTTTGCCACAAAAATTGAAGTAATTTTACACCCTGATCAATCCATTGAAGTCACAGACAA
TGGTCGCGGTATGCCTGTGGATATTCATCCTACGGAAGGCGTTTCTGGCGTAGAAGTGATCCTGACTAAA
CTGCATGCTGGTGGTAAATTCTCCAATAAAAATTATGAATTTGCGGGAGGTTTACACGGTGTGGGGATTT
CTGTGGTAAATGCGCTTTCTGAACGCGTGGATATTCAAGTCAAACGCAATGGCGAAATCTATAAAATTGC
CTTTGAAAACGGCAGTAAAGTAGAAGAATTGGAAATTATCGGGACTTGTGGTAGACGCACAACTGGAACA
ATCGTTCACTTCAAACCAAATCCAAAATATTTTGACAGCGCAAAATTTTCCGTTAGCCGCCTACGCCATT
TATTAAGAGCGAAAGCAGTCCTCTGTTCAGGGCTTGAAATCAAATTCATTGATAAAGTAAACAATACTCA
AGACATTTGGTTATATGAAGATGGGCTTTCCGATTACCTTATCGAAGCAGTAAATGGCTTTGAAACCCTT
CCGAAAAAACCATTTGTTGGCGAATTTAAAGGAGCAAATGAAGCGGTTAGCTGGGCATTACTTTGGTTGC
CAGAAGGTGGCGAACTAATCGGCGAAAGCTACGTAAACTTAATTCCGACTATTCAAGGCGGAACGCATGT
TAATGGCCTACGCCAAGGTTTATTAGATGCTATTCGTGAATTTTGCGAATTTAGAAATCTATTACCACGT
GGGGTAAAACTTACCGCCGATGATATTTGGGATCGCTGTTCTTACATTCTTTCCCTTAAAATGCAGGATG
CGCAATTCGCAGGGCAAACAAAGGAACGCTTATCATCACGCCAAAGTGCGGTGTTTGTCAGCGGTGTTTT
AAAAGATGCGTTCAGCCTATGGCTAAATCAAAATGTACAAGATGCTGAAAAATTGGCAGAAATTGCTATT
AGTTCTGCACAACGCCGATTACGTGCAGCAAAAAAAGTCGTGCGAAAAAAACTCGTTAGTGGCCCTGCAT
TACCAGGAAAATTAGCTGATTGTGGCTCACAGGATTTAGAAAAAACGGAATTATTTTTAGTGGAGGGCGA
CTCTGCGGGCGGTTCAGCAAAACAAGCGCGTGATCGCGAATATCAAGCGATTTTGCCGTTACGTGGGAAA
ATCTTAAACACATGGGAAGTTTCCCCTGATCAAGTATTAGGTTCAACCGAAATTCACGATATCGCCGTGG
CTCTAGGGATCGATCCTGACAGCAATGATTTATCACAACTTCGCTATGGTAAAGTCTGTATTCTCGCGGA
TGCTGACTCCGATGGTCTGCATATTGCCACCCTACTCTGTGCCCTGTTCTTACGTCATTTTCCGAAATTG
GTACAAGACGGTCACGTTTACGTAGCAATGCCACCACTTTATCGCATTGACTTAAATAAAGAAGTCTTCT
ACGCATTAGATGAAAATGAAAAAGAGGCGATTTTAGATCGGTTGAAAAACAAAAAAGGCAAACCGAATGT
TCAACGCTTTAAAGGTTTAGGTGAAATGAACCCATCGCAATTGCGTGAAACAACAATGGATCCTAATACG
CGCCGTCTCGTTCAATTAACTTATGATTTAGGGGAAGATCAAGGCTCAGATACATTAGAACTGATGGATA
TGTTATTAGCGAAAAAACGTTCCGAAGACCGTAAAAATTGGTTACAAGCGAAAGGCGATCAGGTTGATTT
ATCTGTTTA
Protein Sequence 
>gi|16273428|ref|NP_439677.1| DNA topoisomerase IV subunit B [Haemophilus influenzae Rd KW20]
MTTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFATKIEVILHPDQSIEVTDN
GRGMPVDIHPTEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQVKRNGEIYKIA
FENGSKVEELEIIGTCGRRTTGTIVHFKPNPKYFDSAKFSVSRLRHLLRAKAVLCSGLEIKFIDKVNNTQ
DIWLYEDGLSDYLIEAVNGFETLPKKPFVGEFKGANEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHV
NGLRQGLLDAIREFCEFRNLLPRGVKLTADDIWDRCSYILSLKMQDAQFAGQTKERLSSRQSAVFVSGVL
KDAFSLWLNQNVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGKLADCGSQDLEKTELFLVEGD
SAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQLRYGKVCILAD
ADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALDENEKEAILDRLKNKKGKPNV
QRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSDTLELMDMLLAKKRSEDRKNWLQAKGDQVDL
SV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: parE mutant is attenuated in rats (Herbert et al., 2002).
COG COG0187L, under L: Replication, recombination and repair
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].