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ompP2

Victor ID 2875
Gene Name ompP2
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 951048
NCBI Protein GI 16272106
Locus Tag HI0139
Genbank Accession L42023
Protein Accession NP_438308
Other Database IDs UniProtKB-ID: OPP21_HAEIN
UniRef100: UniRef100_P43839
UniRef90: UniRef90_P20149
UniRef50: UniRef50_P20149
UniParc: UPI0000130D3B
EMBL: L42023
EMBL-CDS: AAC21810.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI0139
NMPDR: fig|71421.1.peg.130
TIGR: HI_0139
HOGENOM: HBG495715
OMA: QYELMED
ProtClustDB: CLSK892359
BioCyc: HINF71421:HI_0139-MONOMER
Taxonomy ID 71421
Gene Starting Position 154038
Gene Ending Position 155117
Gene Strand (Orientation) +
Protein Name outer membrane protein P2
Protein pI 9.41
Protein Weight 36894.11
Protein Length 359
Protein Note similar to GB:J03359 SP:P20149
DNA Sequence 
>gi|16271976:154038-155117 Haemophilus influenzae Rd KW20 chromosome, complete genome
TATGAAAAAAACACTTGCAGCATTAATCGTTGGTGCATTCGCAGCTTCAGCAGCAAACGCAGCTGTTGTT
TATAACAACGAAGGGACTAACGTAGAATTAGGTGGTCGTTTAAGCATTATCGCAGAACAAAGTAATAGCA
CTGTAGATAATCAAAAACAGCAACACGGTGCATTACGCAATCAAGGTTCACGTTTCCACATTAAAGCAAC
TCATAACTTCGGTGATGGTTTCTATGCACAAGGTTATTTAGAAACTCGTTTTGTTACAAAAGCCTCTGAA
AACGGTTCAGATAACTTCGGTGATATTACAAGCAAATATGCTTATGTTACTTTAGGAAATAAAGCATTCG
GTGAAGTAAAACTTGGTCGTGCGAAAACTATTGCTGATGGCATAACAAGCGCAGAAGATAAAGAATATGG
CGTTCTCAACAATAGTGACTATATTCCTACTAGTGGTAATACCGTTGGCTATACTTTTAAAGGTATTGAT
GGTTTAGTATTAGGCGCTAATTATTTATTAGCACAAAAGCGTGAGGGTGCAAAAAATACAAATAAGCAGC
CTAATGATAAGGCTGGTGAAGTACGTATAGGTGAAATCAATAATGGAATTCAAGTTGGTGCAAAATATGA
TGCAAACGACATCGTTGCAAAAATTGCTTATGGTAGAACTAACTACAAATATAACGAAGCTGACGAGCAT
ACACAGCAATTAAATGGTGTATTAGCAACTTTAGGCTATCGTTTTAGTGATTTAGGCTTATTAGTGTCTC
TAGATAGTGGCTATGCAAAAACTAAAAACTATAAAACTAAACACGAAAAACGCTATTTCGTATCTCCAGG
TTTCCAATATGAATTAATGGAAGATACTAATGTCTATGGCAACTTCAAATATGAACGCACTTCTGTAGAT
CAAGGTGAAAAAACACGTGAACAAGCAGTATTATTCGGTGTAGATCATAAACTTCACAAACAACTATTAA
CCTATATTGAAGGTGCTTACGCTAGAACTAAAACAACTAATGGAGGCGTAAAAACTGAAAAAGAAAAATC
AGTGGGTGTAGGTTTACGCGTTTACTTCTA
Protein Sequence 
>gi|16272106|ref|NP_438308.1| outer membrane protein P2 [Haemophilus influenzae Rd KW20]
MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSIIAEQSNSTVDNQKQQHGALRNQGSRFHIKAT
HNFGDGFYAQGYLETRFVTKASENGSDNFGDITSKYAYVTLGNKAFGEVKLGRAKTIADGITSAEDKEYG
VLNNSDYIPTSGNTVGYTFKGIDGLVLGANYLLAQKREGAKNTNKQPNDKAGEVRIGEINNGIQVGAKYD
ANDIVAKIAYGRTNYKYNEADEHTQQLNGVLATLGYRFSDLGLLVSLDSGYAKTKNYKTKHEKRYFVSPG
FQYELMEDTNVYGNFKYERTSVDQGEKTREQAVLFGVDHKLHKQLLTYIEGAYARTKTTNGGVKTEKEKS
VGVGLRVYF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels (Sanders et al., 1993). P2 mutants are unable to produce detectable bacteremia in infant rats (Cope et al., 1990).
COG COG3203M, under M: Cell wall/membrane/envelope biogenesis
References
Cope et al., 1990: Cope LD, Pelzel SE, Latimer JL, Hansen EJ. Characterization of a mutant of Haemophilus influenzae type b lacking the P2 major outer membrane protein. Infection and immunity. 1990; 58(10); 3312-3318. [PubMed: 2169463].
Sanders et al., 1993: Sanders JD, Cope LD, Jarosik GP, Maciver I, Latimer JL, Toews GB, Hansen EJ. Reconstitution of a porin-deficient mutant of Haemophilus influenzae type b with a porin gene from nontypeable H. influenzae. Infection and immunity. 1993; 61(9); 3966-3975. [PubMed: 7689543].