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HI1245

Victor ID 2847
Gene Name HI1245
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 949562
NCBI Protein GI 16273164
Locus Tag HI1245
Genbank Accession L42023
Protein Accession NP_439401
Other Database IDs UniProtKB-ID: MAO2_HAEIN
UniRef100: UniRef100_P43837
UniRef90: UniRef90_P43837
UniRef50: UniRef50_Q9ZFV8
UniParc: UPI00000512CB
EMBL: L42023
EMBL-CDS: AAC22896.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI1245
NMPDR: fig|71421.1.peg.1191
TIGR: HI_1245
HOGENOM: HBG289132
OMA: IELAEND
ProtClustDB: PRK07232
BioCyc: HINF71421:HI_1245-MONOMER
Taxonomy ID 71421
Gene Starting Position 1318035
Gene Ending Position 1320305
Gene Strand (Orientation) +
Protein Name malic enzyme
Protein pI 6.52
Protein Weight 76719.98
Protein Length 756
Protein Note NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
DNA Sequence 
>gi|16271976:1318035-1320305 Haemophilus influenzae Rd KW20 chromosome, complete genome
TATGACCGAACAATTACGTCAAGCAGCCTTAGATTTCCACGAATTTCCAATTCCTGGAAAAATCGAAGTT
ACCCCAACAAAATCATTAGCAACCCAACGTGATCTTGCCTTAGCTTATTCACCGGGTGTGGCAGAGCCTT
GTTTAGAAATTGAAAAAGATCCTGCAGCCTCTTACAAATATACAGCACGTGGCAATTTAGTGGCGGTGAT
TTCCAATGGTACAGCGGTGCTTGGGCTTGGCAATATTGGCGCGCTTGCCGGCAAACCTGTAATGGAAGGA
AAGGGCGTGTTGTTCAAAAAATTCGCAGGCATCAACGTGTTTGATATTGAAGTGAATGAACATGATCCCG
ATAAACTTGTAGATATTATTGCCTCGTTAGAGCCAACTTTCGGTGGGGTAAATCTTGAAGATATTAAAGC
ACCGGAATGTTTCTATATTGAACAAAAATTGCGTGAGAGAATGAATATTCCTGTATTCCATGATGACCAA
CATGGCACGGCGATCATCAGCGCTGCCGCGATCATCAATTCTCTTCGTATTGTAGGTAAAAAAATTGAAG
ATGTACGCTTAGTGGCTTCTGGTGCGGGTGCTGCATCTATTGCGTGTTTGAACTTATTGCTTTCTTTAGG
TATGAAACGTGAAAACATCACGGTTTGTGACTCGAAAGGCGTGGTATATAAAGGCCGTGATGACAAAATG
GATCAAACCAAAAAAGAGTATGCAATTGAAGATAATGGCTGGCGTAAACTTGCTGATGCGATTCCAAATG
CAGATATTTTCTTAGGTTGTTCTGCGGCTGGTGCGCTTACACAAGATATGGTTAAAAGTATGGCTGCGCA
TCCAATTATTCTTGCTTTGGCTAATCCAAATCCTGAAATTACCCCGCCAGAAGCAAAAGCAGTTCGTCCT
GATGCGATTGTATGTACAGGCCGCTCTGATTATCCAAACCAAGTAAATAACGTGCTTTGTTTCCCATTTA
TTTTCCGTGGTGCATTAGATGTGGGCGCAACCACTATTAATGAAGAAATGAAACGTGCGGCAGTTTATGC
TATCGCAGACCTTGCATTAGAAGAGCAAAACGAAGTGGTAACCTCTGCTTACGGTGGCGAAGGGGCAACA
TTTGGTGCGGATTATGTGATTCCTCGTCCATTTGATCCTCGCTTGATTGTGCGTATTGCACCAGCGGTAG
CAAAAGCTGCAATGGAATCTGGTGTGGCAACTCGTCCAATTCAAAATTGGGATGCTTATGTTGAAAAACT
CACTCAGTTTGTTTACAAAACGAGCTTGTTTATGCGTCCTATTTTCAGCCAAGCAAAATCGGCAAAACAA
CGCATTATTTTAGCGGAAGGGGAAGAAAATAAAGCATTACATGCCACCCAAGAAGTGATTTCAATGGGCT
TGGCAAATCCAATTTTAATTGGTCGCCGCAGCGTGATTGAAGAAAAAATTAAAAAACTTGGTTTACGTTT
AACTGCAGGTGTAGATTTTGAAATTGTGGATAACGAAGATAATCCTCGCTATGAAGAATGTTGGAAACAC
TATTACGAACTTACTAAACGTAAAGGCATTACACCTGCAATCGCAAAACGTGTCGTGCGTTCTAACACCA
CCGTATTAGCTTCTACATTGCTTAGCTTAGGTTATGCAGACGCTTTAGTATGTGGCTTATTTGGTTCATA
CGGAAAACACCTTGCCTCTATTCGAGATATTATTGGCTTAAAAGACGGTGTGAAAACTGCCGCTGCTTTA
AATAGTCTTGTATTACCGACGGGTAACGTATTCTTAACAGATACTCACGTAAACAGTAATCCTACAGCAG
AAGAATTAGCTGAAATTACCTTAATGGCAGCAGAAGAAATTCATCGTTTTGGTATTGAACCTGCAGTTGC
ATTGCTTTCTCATTCTAATTTTGGTTCATCTGATTCATTAGGCGCACCAAAAATGCGCGAAGTATTACAG
ATCGTCAAAGAGCGCAATCCACATTTAATGATTGATGGGGAAATGCGTGGCGATTTAGCGATGAATGAAG
CACACAGAAAAGAATTAATGCCTGATAGCCCATTGAAAGGAAGCGCAAATTTATTAGTGTTCCCTGATTT
GAGTGCATCACGTATTAGTTATAGCTTATTACGCGGCACTACTACGGCAATTACCGTTGGCCCGATCTTA
ATGGGAATGAATAAATCTGCGCATATTCTTAATCCAGGTGCATCTGTTCGTCGTATTATCAATATGATTG
CCTATGCAGCAGTGAAAGCACAACAAGAGTA
Protein Sequence 
>gi|16273164|ref|NP_439401.1| malic enzyme [Haemophilus influenzae Rd KW20]
MTEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVI
SNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKA
PECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLG
MKRENITVCDSKGVVYKGRDDKMDQTKKEYAIEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAH
PIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYA
IADLALEEQNEVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAAMESGVATRPIQNWDAYVEKL
TQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIEEKIKKLGLRL
TAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSY
GKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVA
LLSHSNFGSSDSLGAPKMREVLQIVKERNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDL
SASRISYSLLRGTTTAITVGPILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: HI1245 mutant is attenuated in rats (Herbert et al., 2002)
COG COG0281C, under C: Energy production and conversion
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].