Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

HI1677

Victor ID 2870
Gene Name HI1677
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 950862
NCBI Protein GI 16273564
Locus Tag HI1677
Genbank Accession L42023
Protein Accession NP_439819
Other Database IDs UniProtKB-ID: Y1677_HAEIN
UniRef100: UniRef100_P45312
UniRef90: UniRef90_P45312
UniRef50: UniRef50_A7MM70
UniParc: UPI000013C139
EMBL: L42023
EMBL-CDS: AAC23322.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI1677
NMPDR: fig|71421.1.peg.1590
TIGR: HI_1677
HOGENOM: HBG308681
OMA: GNPINAM
ProtClustDB: PRK10992
BioCyc: HINF71421:HI_1677-MONOMER
Taxonomy ID 71421
Gene Starting Position 1745681
Gene Ending Position 1746352
Gene Strand (Orientation) +
Protein Name iron-sulfur cluster repair di-iron protein
Protein pI 4.72
Protein Weight 24496.03
Protein Length 223
Protein Note Involved in anaerobic NO protection and iron metabolism
DNA Sequence 
>gi|16271976:1745681-1746352 Haemophilus influenzae Rd KW20 chromosome, complete genome
TATGTCTTTTGCCCAACAAAAACTTAGCGAACTCGCTGTTTCAATTCCAGGTGCAACTAAAATTTTTCGT
GAATATGATTTAGATTTTTGCTGCGGAGGTTCTGTATTATTAGAAGTCGCAGCACAACAAAAGAATCTTA
ACCTTGCTGAAATTGAAAAACGTTTAACTGATTTACAACAAAGTAAAGCAGAAAATAATGATAAAGATTG
GACTTCGGCATCTTATGCGGAGATGATCGATCACATTATTACTCGTTTTCATAATCGCCACCGTGAACAA
CTCCCTGAATTAATTACATTGGCGGAGAAAGTAGAAAATATACATGGTGATCGTGATGACTGTCCTATAG
GCGTAGTCGCACAGTTAGAAAAAATTTATGCTGAACTTAGCCAGCATTTAATGAAAGAAGAACAAATTTT
GTTCCCAATGATCAAAATGGGGAATTATGCTATGGCCTCAATGCCAATTCGTGTAATGGAAATGGAACAC
GATGAAGCAGGACAAGATGTGGAAGTGATCAAATCGCTTACTAATAACTGCACGCCACCAGCAGATGCTT
GTTTCAGTTGGAAAGCCTTATATAGCGGTATTAATGAATTTATTGATGATTTAATGCATCATATTCATTT
GGAAAATAATATTTTATTTCCACGTGTATTAAACGAAAAATA
Protein Sequence 
>gi|16273564|ref|NP_439819.1| iron-sulfur cluster repair di-iron protein [Haemophilus influenzae Rd KW20]
MSFAQQKLSELAVSIPGATKIFREYDLDFCCGGSVLLEVAAQQKNLNLAEIEKRLTDLQQSKAENNDKDW
TSASYAEMIDHIITRFHNRHREQLPELITLAEKVENIHGDRDDCPIGVVAQLEKIYAELSQHLMKEEQIL
FPMIKMGNYAMASMPIRVMEMEHDEAGQDVEVIKSLTNNCTPPADACFSWKALYSGINEFIDDLMHHIHL
ENNILFPRVLNEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Compared to the wild-type strain, the ytfE (HI1677) mutant exhibited decreased survival when exposed to macrophages, a defect that was more pronounced after prior stimulation of macrophages with IFN-gamma or lipopolysaccharide. Complementation restored survival of the mutant to the level in the parental strain (Harrington et al., 2009).
COG COG2846D, under D: Cell cycle control, cell division, chromosome partitioning
References
Harrington et al., 2009: Harrington JC, Wong SM, Rosadini CV, Garifulin O, Boyartchuk V, Akerley BJ. Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene. Infection and immunity. 2009; 77(5); 1945-1958. [PubMed: 19289513].