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metB

Victor ID 2873
Gene Name metB
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 950982
NCBI Protein GI 16272060
Locus Tag HI0086
Genbank Accession L42023
Protein Accession NP_438259
Other Database IDs UniProtKB-ID: METB_HAEIN
UniRef100: UniRef100_P44502
UniRef90: UniRef90_P44502
UniRef50: UniRef50_P44502
UniParc: UPI000012EF5E
EMBL: L42023
EMBL-CDS: AAC21764.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI0086
NMPDR: fig|71421.1.peg.85
TIGR: HI_0086
HOGENOM: HBG754729
OMA: MRQHEEN
ProtClustDB: PRK08247
BioCyc: HINF71421:HI_0086-MONOMER
Taxonomy ID 71421
Gene Starting Position 90189
Gene Ending Position 91334
Gene Strand (Orientation) -
Protein Name cystathionine gamma-synthase
Protein pI 5.11
Protein Weight 39427.79
Protein Length 381
Protein Note catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity
DNA Sequence 
>gi|16271976:90189-91334 Haemophilus influenzae Rd KW20 chromosome, complete genome
ATTATTTTAAGTTTGCAAAAGCTTGTAATAAGTCCGCTTTAATATCTTCTACATCTTCAATACCGACTGA
AAAACGCAACAAGGTATTAGTAATCCCACGAGCTACACGCTCGGATTCTGGAATATCCATATGAGTTTGA
GTGGCAGGATAAGTAATAAAACTTTCTGTGCCGCCTAGACTTTCTGCAAAAGTAATCAATTTGATGGATT
TTAAAAATGTATTAACCCAAGCTTCATCTTGCAAACGGAAAGACAACATCCCACCTTTATTCGGATAAAG
CACCGATTCCACTTGTGGTTGAGCTTTTAAAAATTCCGCAATAGCTTGTGCATTTTCTTGATGGCGTTTC
ATACGCAAAGAAAGGGTCTTCATACCACGAATAGTCAGCCAAGAATCAAAAGGAGAAAGCACCGCCCCTG
CACCATTTTGAATATAAGCAATGCGATCACAAAGTTCTTGCCCTTTCGCAACAATTAAACCAACAAGTGC
ATCATTATGCCCAGCAATATATTTAGTTCCGCTGTGAATTACCACATCCGCACCTAAATCTAATGGACGA
GAAAGCACAGGCGTTAAAAACGTATTATCCACGATCAACATTAAGTTATGTTTTTTCGCAAGTTTTGCAA
TTTCAACCACATCACATTCTTCCATTAAAGGATTCGATGGGGTTTCAATAAAAATCGCTTTCGTATTTGG
GTTAATGGCAGCCTCAATTGCTGAAGCAGATGCTGTATTAACATAAACAGGTTTTACACTATTGTTATTT
TTATAAGAAAAATCTAATAATCGATAAGTACCACCATACACATCGCTAGAAACAATCCATTCATCTGGGG
CGGTAAAAAGCGTCATCAAAACTTGAATTGCAGCCATACCAGAAGAAAACGCAAAACCACGATCTCCATT
CTCTAATTTAGCTATCGTTTCTTCTAATACTGTGCGAGTTGGATTTTTGGTACGTGTGTAATCAAATCCC
GTACTTTCACCGATACCACAATGACCATAAGCCGTAGAAAGAAAAATTGGTGCAGAAACCGCGCCCGTAC
GCTCATCACTGCGATTGCCTGCTTGAGCTAATAAAGTATCGATAGCATATTGTTGTGTCATAACATCCTC
TAAAAATAATGAAAAAATTGACCGCA
Protein Sequence 
>gi|16272060|ref|NP_438259.1| cystathionine gamma-synthase [Haemophilus influenzae Rd KW20]
MRSIFSLFLEDVMTQQYAIDTLLAQAGNRSDERTGAVSAPIFLSTAYGHCGIGESTGFDYTRTKNPTRTV
LEETIAKLENGDRGFAFSSGMAAIQVLMTLFTAPDEWIVSSDVYGGTYRLLDFSYKNNNSVKPVYVNTAS
ASAIEAAINPNTKAIFIETPSNPLMEECDVVEIAKLAKKHNLMLIVDNTFLTPVLSRPLDLGADVVIHSG
TKYIAGHNDALVGLIVAKGQELCDRIAYIQNGAGAVLSPFDSWLTIRGMKTLSLRMKRHQENAQAIAEFL
KAQPQVESVLYPNKGGMLSFRLQDEAWVNTFLKSIKLITFAESLGGTESFITYPATQTHMDIPESERVAR
GITNTLLRFSVGIEDVEDIKADLLQAFANLK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: metB mutant is attenuated in rats (Herbert et al., 2002).
COG COG0626E, under E: Amino acid transport and metabolism
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].