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oapA from Haemophilus influenzae 86-028NP

Victor ID 2830
Gene Name oapA from Haemophilus influenzae 86-028NP
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
NCBI Gene ID 3429769
NCBI Protein GI 68248935
Locus Tag NTHI0448
Protein Accession YP_248047.1
Other Database IDs UniProtKB-ID: Q4QNL0_HAEI8
UniRef100: UniRef100_Q4QNL0
UniRef90: UniRef90_P44415
UniRef50: UniRef50_P44415
UniParc: UPI000053E091
EMBL: CP000057
EMBL-CDS: AAX87387.1
RefSeq_NT: NC_007146.2
GenomeReviews: CP000057_GR
KEGG: hit:NTHI0448
eggNOG: COG3061
HOGENOM: HBG297166
OMA: ENISAVD
ProtClustDB: CLSK869964
BioCyc: HINF281310:NTHI0448-MONOMER
Taxonomy ID 281310
Gene Starting Position 425767
Gene Ending Position 427062
Gene Strand (Orientation) +
Protein Name opacity associated protein OapA
DNA Sequence 
>gi|162960935:425767-427062 Haemophilus influenzae 86-028NP, complete genome
AGTGAATTCTATGGATAAAAATCAACAATCATCTCAAAATGAATTGGATTTAGGGCTTAATCAAGAGCCA
ATTACACCAAAGAAAACAATTCAGCCAAGTTCGTCAATTTTAGGTAAAGCAAAAGGGTTATTTGCCAAAA
AAAATCACGTGCAAACTAACTTTCAGCAACGTAAAGAACCTACTTTTGGCGATTCATCAACGCAAGAAAA
TGATCCTTTAATTCCGAGTGAAAATTTGAAAAAAGTGCAAAAGCCTGTTCTTCAAACTTCTTCCACAGAA
GAAAATATTTCTGCGGTTGATGAAGAAATCAGTGCTGAAAATAACGCGGATGAACCCGTCGAAAAGGCTG
AAAAACCTATTTTAGCTCAACCAGAAAAATGGAAAATATTACAAGTATTGCCAGCAAAACATCGCCGTTT
ATTTATGGCTATTTTTGTGTTGGTTATTTTATTGATTATTTTCTTCGCATTAAAACCAAGTTCTGACACC
GTTGAGTCTTTTACTCAATCTAACAGCAATGAAGTTCCTGTGCAGTTCCAATCGTTAGATCAAAGTCAGC
CACTGGAAACCACGATTTTAGATAATCCTCCTGCACAAAATCAAATGGCTGTAGAACAAGCTAACCAATC
TGAATTTGCACCAAAAGCAGAGGAAGCGGCGAATAATACGACGGCTCAAAACCCATTAGTAGAAAATGCG
CCAATGCAACAAAATGTTGTTCAATCTCCAAGTCAAATGCCAAATGAAATGGCTGCGGCATCTGTTATGC
CTATGCAACCAGCTCAAGCGGAACAGCCAAAAGCAACTGTGCCAGTTCAGCCGATGAAAAAAGCGGTAGA
GCCACAAGTTGCGCATAAAGATACTGTGAAAAAAGAAGTGAAAGTGGCGGAGAATGCACAGGCTCCATCA
AAAGCAACGGAACAAAACGTCGCTAAAACAGCAGGAAACGCACCGATTGTTGAAGCCAAACCTGTTCAAG
TAAAAAAAGAAAAGAAAGTTCAAATCGTTGATGCAAAACCTGTGAGTAAATCTGCAGCCTCTCGTCTTTC
TGCGAAAACATTAACTGTGCCGAAAGGTGTTTCGCTGATGCAAGTCTTCCGTGATAATCAACTTAATATT
TCCGATGTAAACGCAATGAGCAAAGCAGCAGGGGCGGGCAATGTTTTAAGTAGCTTTAAATCTGGCGATA
AAGTAACGGTATCTGTGAATAATCAAGGGCGAGTAAATGAAATGCGTTTATCCAATGGTGCGCGTTTTGT
GCGTCAGTCTGATGGTTCTTATCAATATAAAAAATA
Protein Sequence 
>gi|68248935|ref|YP_248047.1| opacity associated protein [Haemophilus influenzae 86-028NP] MNSMDKNQQSSQNELDLGLNQEPITPKKTIQPSSSILGKAKGLFAKKNHVQTNFQQRKEPTFGDSSTQENDPLIPSENLKKVQKPVLQTSSTEENISAVDEEISAENNADEPVEKAEKPILAQPEKWKILQVLPAKHRRLFMAIFVLVILLIIFFALKPSSDTVESFTQSNSNEVPVQFQSLDQSQPLETTILDNPPAQNQMAVEQANQSEFAPKAEEAANNTTAQNPLVENAPMQQNVVQSPSQMPNEMAAASVMPMQPAQAEQPKATVPVQPMKKAVEPQVAHKDTVKKEVKVAENAQAPSKATEQNVAKTAGNAPIVEAKPVQVKKEKKVQIVDAKPVSKSAASRLSAKTLTVPKGVSLMQVFRDNQLNISDVNAMSKAAGAGNVLSSFKSGDKVTVSVNNQGRVNEMRLSNGARFVRQSDGSYQYKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type (Prasadarao et al., 1999).
COG COG3061M, under M: Cell wall/membrane/envelope biogenesis
References
Prasadarao et al., 1999: Prasadarao NV, Lysenko E, Wass CA, Kim KS, Weiser JN. Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells. Infection and immunity. 1999; 67(8); 4153-4160. [PubMed: 10417187].