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siaB

Victor ID 2839
Gene Name siaB
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
NCBI Gene ID 3431148
NCBI Protein GI 68250197
Locus Tag NTHI1891
Genbank Accession CP000057
Protein Accession YP_249309
Other Database IDs UniProtKB-ID: Q4QJZ8_HAEI8
UniRef100: UniRef100_Q4QJZ8
UniRef90: UniRef90_Q57140
UniRef50: UniRef50_Q57140
UniParc: UPI000053E2CA
EMBL: CP000057
EMBL-CDS: AAX88649.1
RefSeq_NT: NC_007146.2
GenomeReviews: CP000057_GR
KEGG: hit:NTHI1891
eggNOG: COG1083
HOGENOM: HBG656811
OMA: IKDKNLQ
ProtClustDB: CLSK789358
BioCyc: HINF281310:NTHI1891-MONOMER
Taxonomy ID 281310
Gene Starting Position 1728849
Gene Ending Position 1729523
Gene Strand (Orientation) -
Protein Name acylneuraminate cytidylyltransferase
Protein pI 6.13
Protein Weight 23913.67
Protein Length 224
Protein Note Similar to: HI1279, NEUA_HAEIN
DNA Sequence 
>gi|162960935:1728849-1729523 Haemophilus influenzae 86-028NP chromosome, complete genome
TTTAGAATTCTTTTGAAATTAAACTTTCGGCTAATTGCAAATCAAGTGTGGAGTCAATATCAATGGAACG
ATAAGTTGGCATTAAATAAAAACGCATTGGCGCAATAAAAAAGCGTTTTTCTTCAAAGAGACTTTCGATG
TCATTAATATAAATTGCGCCATTTGCACGATAAGATTTGGGTAATTTTTGACGAGGGGCTTCAAAATCCG
TTAATTCGTGAATAGGCTGAACTTCGGTACCTTCTAAAGTGAAGGATTTATAAGGATGATGCTCACATTC
GCAAGCGGAAACCACTGACTTATATTTGCCGCCAAGGAAAATTTCCATTGCATTACGAATATCTAAAGCA
TTACGCAATGGGCTGGTTGGTTGCAAAAGTGCAGCGGTGCCTTGTGAAATATTAAGTGTTTCTAAGCAAT
GCAAAATTGCATCAATGGTGCGTGTATCACTTTGCGCCAAACTTTCAGGGCGTGCCACTGGTTTTGCGCC
GTATTTTGTGGCTTCTTTTAAAATATTTTCACCGTCTGATGTCACCACAATTTGATCAAACATACCCGAT
TCTTGCGCTGCCAAAATCGCACGCCCCACCAAAGAAACACCACCCACAAGCTGTAAATTTTTGTCTTTAA
TTCCTTTAGAACCCGCTCTCGCAGGAATAATTGCAATTCTTGTCA
Protein Sequence 
>gi|68250197|ref|YP_249309.1| acylneuraminate cytidylyltransferase [Haemophilus influenzae 86-028NP]
MTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARP
ESLAQSDTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYK
SFTLEGTEVQPIHELTDFEAPRQKLPKSYRANGAIYINDIESLFEEKRFFIAPMRFYLMPTYRSIDIDST
LDLQLAESLISKEF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: siaB mutant is attenuated in chinchillas (Bouchet et al., 2003).
COG COG1083M, under M: Cell wall/membrane/envelope biogenesis
References
Bouchet et al., 2003: Bouchet V, Hood DW, Li J, Brisson JR, Randle GA, Martin A, Li Z, Goldstein R, Schweda EK, Pelton SI, Richards JC, Moxon ER. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(15); 8898-8903. [PubMed: 12855765].