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oapA from Haemophilus influenzae Rd KW20

Victor ID 2843
Gene Name oapA from Haemophilus influenzae Rd KW20
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 949442
NCBI Protein GI 16272282
Locus Tag HI0330
Protein Accession NP_438494.1
Other Database IDs UniProtKB-ID: OAPA_HAEIN
UniRef100: UniRef100_P44415
UniRef90: UniRef90_P44415
UniRef50: UniRef50_P44415
UniParc: UPI0000130B61
EMBL: U17037
EMBL: L42023
EMBL-CDS: AAA56761.1
EMBL-CDS: AAC21992.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI0330
NMPDR: fig|71421.1.peg.309
TIGR: HI_0330
HOGENOM: HBG297166
OMA: ENISAVD
ProtClustDB: CLSK869964
BioCyc: HINF71421:HI_0330-MONOMER
Taxonomy ID 71421
Gene Starting Position 357366
Gene Ending Position 358661
Gene Strand (Orientation) +
Protein Name opacity associated protein
DNA Sequence 
>gi|16271976:357366-358661 Haemophilus influenzae Rd KW20, complete genome
AGTGAATTCTATGGATAAAAATCAACAATCATCTCAAAATGAATTGGATTTAGGGCTTAATCAAGAGCCA
ATTACACCAAAGAAAACAATTCAGCCAAGTTCGTCAATTTTAGGTAAAGCAAAAGGGTTATTTGCCAAAA
AAAATCACGTGCAAACTAACTTTCAGCAACGTAAAGAACCTACTTTTGGCGATTCATCAACGCAAGAAAA
TGATCCTTTAATTCCGAGTGAAAATTTGAAAAAAGTGCAAAAGCCTGTTCTTCAAACTTCTTCCACAGAA
GAAAATATTTCTGCGGTTGATGAAGAAATCAGTGCTGAAAATAACGCGGATGAACCCGTCGAAAAGGCTG
AAAAACCTATTTTAGCTCAACCAGAAAAATGGAAAATATTACAAGTATTGCCAGCAAAACATCGCCGTTT
ATTTATGGCTATTTTTGTGTTGGTTATTTTATTGATTATTTTCTTCGCATTAAAACCAAGTTCTGACACC
GTTGAGTCTTTTACTCAATCTAACAGCAATGAAGTTCCTGTGCAGTTCCAATCGTTAGATCAAAGTCAGC
CACTGGAAACCACGATTTTAGATAATCCTCCTGCACAAAATCAAATGGCTGTAGAACAAGCTAACCAATC
TGAATTTGCACCAAAAGCAGAGGAAGCGGCGAATAATACGACGGCTCAAAACCCATTAGTAGAAAATGCG
CCAATGCAACAAAATGTTGTTCAATCTCCAAGTCAAATGCCAAATGAAATGGCTGCGGCATCTGTTGCGC
CTATGCAACCAGCTCAAGCGGAACAGCCAAAAGCAACTGTGCCAGTTCAGCCGATGAAAAAAGCGGTAGA
GCCACAAGTTGCGCATAAAGATACAGTGAAAAAAGAAGTGAAAGTGGCGGAGAAAGCACAGGCTCCAGCA
AAAGCAACGGAACAAAACGTCGCTAAAACAGCAGGAAACGCACCGATTGTTGAAGCCAAACCTGTTCAAG
CTAAAAAAGAAAAGAAAGTTCAAATCGTTGATGCAAAACCTGTGAGTAAATCTACAGCTTCTCGCCTTTC
AGCAAAAACATTAACTGTGCCGAAAGGTGTTTCGCTGATGCAACTCTTCCGTGATAATCAACTTAATATT
TCCGATGTAAACGCAATGAGCAAAGCGACAGGGGCGGGAAATGTTTTAAGTAGCTTTAAATCTGGCGATA
AAGTAACGGTATCTGTGAATAATCAAGGGCGAGTAAATGAAATGCGTTTATCCAATGGTGCGCGTTTTGT
GCGTCAGTCTGATGGTTCTTATCAATATAAAAAATA
Protein Sequence 
>gi|16272282|ref|NP_438494.1| opacity associated protein [Haemophilus influenzae Rd KW20] MNSMDKNQQSSQNELDLGLNQEPITPKKTIQPSSSILGKAKGLFAKKNHVQTNFQQRKEPTFGDSSTQENDPLIPSENLKKVQKPVLQTSSTEENISAVDEEISAENNADEPVEKAEKPILAQPEKWKILQVLPAKHRRLFMAIFVLVILLIIFFALKPSSDTVESFTQSNSNEVPVQFQSLDQSQPLETTILDNPPAQNQMAVEQANQSEFAPKAEEAANNTTAQNPLVENAPMQQNVVQSPSQMPNEMAAASVAPMQPAQAEQPKATVPVQPMKKAVEPQVAHKDTVKKEVKVAEKAQAPAKATEQNVAKTAGNAPIVEAKPVQAKKEKKVQIVDAKPVSKSTASRLSAKTLTVPKGVSLMQLFRDNQLNISDVNAMSKATGAGNVLSSFKSGDKVTVSVNNQGRVNEMRLSNGARFVRQSDGSYQYKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type (Prasadarao et al., 1999).
COG COG3061M, under M: Cell wall/membrane/envelope biogenesis
References
Prasadarao et al., 1999: Prasadarao NV, Lysenko E, Wass CA, Kim KS, Weiser JN. Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells. Infection and immunity. 1999; 67(8); 4153-4160. [PubMed: 10417187].