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HI1459

Victor ID 2860
Gene Name HI1459
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 950350
NCBI Protein GI 30995451
Locus Tag HI1459
Genbank Accession L42023
Protein Accession NP_439610
Other Database IDs UniProtKB-ID: Y1459_HAEIN
UniRef100: UniRef100_P45215
UniRef90: UniRef90_P45215
UniRef50: UniRef50_P45215
UniParc: UPI000011DD90
EMBL: L42023
EMBL-CDS: AAC23107.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI1459
NMPDR: fig|71421.1.peg.1391
TIGR: HI_1459
HOGENOM: HBG296729
OMA: WIFAILK
ProtClustDB: PRK12530
BioCyc: HINF71421:HI_1459-MONOMER
Taxonomy ID 71421
Gene Starting Position 1542230
Gene Ending Position 1542775
Gene Strand (Orientation) -
Protein Name RNA polymerase sigma factor
Protein pI 4.81
Protein Weight 20843.18
Protein Length 181
Protein Note Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
DNA Sequence 
>gi|16271976:1542230-1542775 Haemophilus influenzae Rd KW20 chromosome, complete genome
CCTAAAGTTTTTTTGAAAGACAGTTTTGCAACTGTAAACGAGCCCGATAAAGGGTGGTATGTAAATTAGA
CGAAGTTAAATGTGTTTCTTGACAAATTTCTTCAGATGAAAGCTCTAAAAACTCTCGCATCATAAAAATT
TTTGCCTGTTTAGCAGGTAAACAATTCAAACAAGTTTCAAAAATCAGCCAAAATTCATCGGAATAAACCG
TTTCTTCTTCGCCTTGTAATTCACTCGGGTGATATTCTGGTTTCCAATGCCCCTTTTCATCAAAAAATGA
ATTATTAGTATTTTCATCTTCAAGTTCACTTTCTAAAACAAACCGCCCTTTCTGACGTAAATAATCAATA
ATCTTATTTTTAAGAATCGCAAAAATCCAAGTCTTAAATGCAGATTGACGCTTAAAATTAGCGAGATTTT
TGAATGCACTTAAAAAAGCTTCTTGTACTAAATCTTCAGCAAGATCGGCTTGATTTACTTGCAATTGTGC
AAATGTCAGCATTTGAGTGCGAATTTGCTGAAGCTCAAGATCAGAAATAACATTCA
Protein Sequence 
>gi|30995451|ref|NP_439610.2| RNA polymerase sigma factor [Haemophilus influenzae Rd KW20]
MNVISDLELQQIRTQMLTFAQLQVNQADLAEDLVQEAFLSAFKNLANFKRQSAFKTWIFAILKNKIIDYL
RQKGRFVLESELEDENTNNSFFDEKGHWKPEYHPSELQGEEETVYSDEFWLIFETCLNCLPAKQAKIFMM
REFLELSSEEICQETHLTSSNLHTTLYRARLQLQNCLSKKL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: HI1459 mutant is attenuated in rats (Herbert et al., 2002).
COG COG1595K, under K: Transcription
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].