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ompP2 from Haemophilus influenzae 86-028NP

Victor ID 2827
Gene Name ompP2 from Haemophilus influenzae 86-028NP
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
NCBI Gene ID 3429565
NCBI Protein GI 68248747
Locus Tag NTHI0225
Protein Accession YP_247859.1
Other Database IDs UniProtKB-ID: Q4QP48_HAEI8
UniRef100: UniRef100_Q4QP48
UniRef90: UniRef90_Q48218
UniRef50: UniRef50_P46026
UniParc: UPI000053E042
EMBL: CP000057
EMBL-CDS: AAX87199.1
RefSeq_NT: NC_007146.2
GenomeReviews: CP000057_GR
KEGG: hit:NTHI0225
eggNOG: COG3203
HOGENOM: HBG495715
OMA: QYELMED
ProtClustDB: CLSK892359
BioCyc: HINF281310:NTHI0225-MONOMER
Taxonomy ID 281310
Gene Starting Position 216248
Gene Ending Position 217345
Gene Strand (Orientation) +
Protein Name OMP P2
DNA Sequence 
>gi|162960935:216248-217345 Haemophilus influenzae 86-028NP, complete genome
TATGAAAAAAACACTTGCAGCATTAATCGTTGGTGCATTCGCAGCTTCAGCAGCAAACGCAGCTGTTGTT
TATAACAACGAAGGGACTAACGTAGAATTAGGTGGTCGTTTAAGCATTATCGCAGAACAAAGTAATAGCA
CTATAAAGGATCAAAAACAGCAACACGGTGCATTACGCAATCAAAGTTCACGTTTCCACATTAAAGCAAC
TCATAACTTCGGTGATGGTTTCTATGCACAAGGTTATTTAGAAACTCGTTTAGTTTCAGCTCAATCTGGA
ACCGAGTCAGATAACTTCGGTCATATTATAACCAAATATGCTTATGTCACTTTAGGAAATAAAGCATTGG
GTGAAGTAAAACTTGGTCGTGCGAAAACTATTGCTGATGGCATAACAAGCGCAGAAGATAAAGAATATGG
TGTTCTCAACAATAGCAAATATATTCCTACTAATGGTAATACCGTTGGCTACACTTTTAAAGGTATCGAT
GGTTTAGTATTAGGTGCTAATTATTTATTAGCACAAGAGCGTCATAAGTATACTACTGCTGCTGGTACTC
GTGCTGTTACTGTTGCAGGAGAAGTTTATCCACAAAAAATCAGCAATGGCGTTCAGGTTGGTGCAAAATA
TGATGCAAACAACATTATTGCAGGTATTGCTTATGGTCGTACAAATTATAGAGAAGATATTGTTGACCCA
GATTTAGGTAAAAAACAACAAGTAAACGGTGCGCTTTCAACTTTAGGCTATCGTTTTAGTGATTTAGGCT
TATTAGTGTCTCTAGATAGTGGCTATGCAAAAACTAAAAACTATAAAGATAAACACGAAAAAAGCTATTT
CGTATCTCCAGGTTTCCAATATGAATTAATGGAAGATACTAATGTCTATGGCAACTTCAAATATGAACGC
GATTCTGTAGATCAAGGTAAAAAAACACGTGAACAAGCAGTGTTATTCGGTGTAGATCATAAACTTCACA
AACAAGTATTAACCTATATTGAAGGTGCTTACGCTAGAACTAGAACAACTGAGCAAGCTAAAGGCGTAAA
AACTGAAAAAGAAAAATCAGTGGGTGTAGGTTTACGCGTTTACTTCTA
Protein Sequence 
>gi|68248747|ref|YP_247859.1| outer membrane protein P2 [Haemophilus influenzae 86-028NP] MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSIIAEQSNSTIKDQKQQHGALRNQSSRFHIKATHNFGDGFYAQGYLETRLVSAQSGTESDNFGHIITKYAYVTLGNKALGEVKLGRAKTIADGITSAEDKEYGVLNNSKYIPTNGNTVGYTFKGIDGLVLGANYLLAQERHKYTTAAGTRAVTVAGEVYPQKISNGVQVGAKYDANNIIAGIAYGRTNYREDIVDPDLGKKQQVNGALSTLGYRFSDLGLLVSLDSGYAKTKNYKDKHEKSYFVSPGFQYELMEDTNVYGNFKYERDSVDQGKKTREQAVLFGVDHKLHKQVLTYIEGAYARTRTTEQAKGVKTEKEKSVGVGLRVYF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels (Sanders et al., 1993). P2 mutants are unable to produce detectable bacteremia in infant rats (Cope et al., 1990).
COG COG3203M, under M: Cell wall/membrane/envelope biogenesis
References
Cope et al., 1990: Cope LD, Pelzel SE, Latimer JL, Hansen EJ. Characterization of a mutant of Haemophilus influenzae type b lacking the P2 major outer membrane protein. Infection and immunity. 1990; 58(10); 3312-3318. [PubMed: 2169463].
Sanders et al., 1993: Sanders JD, Cope LD, Jarosik GP, Maciver I, Latimer JL, Toews GB, Hansen EJ. Reconstitution of a porin-deficient mutant of Haemophilus influenzae type b with a porin gene from nontypeable H. influenzae. Infection and immunity. 1993; 61(9); 3966-3975. [PubMed: 7689543].