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nudC

Victor ID 2846
Gene Name nudC
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 949531
NCBI Protein GI 16272380
Locus Tag HI0432
Genbank Accession L42023
Protein Accession NP_438593
Other Database IDs UniProtKB-ID: NUDC_HAEIN
UniRef100: UniRef100_P44710
UniRef90: UniRef90_Q4QNB3
UniRef50: UniRef50_Q65W71
UniParc: UPI00000512C0
EMBL: L42023
EMBL-CDS: AAC22091.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI0432
NMPDR: fig|71421.1.peg.406
TIGR: HI_0432
HOGENOM: HBG736436
OMA: SPCIIVA
ProtClustDB: PRK00241
BioCyc: HINF71421:HI_0432-MONOMER
Taxonomy ID 71421
Gene Starting Position 454735
Gene Ending Position 455529
Gene Strand (Orientation) -
Protein Name NADH pyrophosphatase
Protein pI 4.82
Protein Weight 28773.35
Protein Length 264
Protein Note can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
DNA Sequence 
>gi|16271976:454735-455529 Haemophilus influenzae Rd KW20 chromosome, complete genome
ATTAATCGCATTTATGTTCCGCTTTACAAAGTTCAAGCGTCACATGAATTAATTTGCGAGCGATAGTACC
CGTTGGCGGTAATTCTGGCAAGGGTTGATCATAAGAAAACCATTGTGCATCGTGAATTTCACTTTCCTGC
AATGTTATTTCTCCGCTTTCATAATCAGCAAGAAAGCCGACCATTTGAGAGTTTGGAAATGCCCAAGGCT
GGCTACCGAAATAACGAAGATTTTTTATTGAAATCCCTGTTTCTTCAAAAACCTCTCTCTGCACTGCTTG
TTCAAATGTTTCCCCTACTTCGACAAAACCTGCAAGCGTCGTGTATATTCCTCCGTTAGGACTATAATGT
CGCTTATGATTTGCCAATAGAATTTCGTGACCACGACGAACCGCAACAATAATTGATGGGCAAATCACAG
GATAAGTTTGATACCCACAGTGAATACATTGCACAGCAAGTTCATCTTGAGTTTGTTGTGTTTTATGACC
GCACTTTCCACAGAATTTATGGGTTTTCAGAAAATGATTAATTTCCACACCTCGGCTTAATATATGGAAT
TCATCCTCTGGCAGTGAAAGCAAGTTACTCAAACTCACATATTCTCGTTCATCACTTTCTTGCTCAGCCA
CAAGCCACAACGGATAATTTTTCCATTCCCCAATTTGCATTGCCTGCAATCCTTCCAAATCAATATCTTT
AGCGATACCAAAAGGCAATTCATTATTCACTAAATACAGATTAGAACCTTGTGTAAGCAACCAATAACCA
AAATCATCTTGTTGAAGTATTTTCA
Protein Sequence 
>gi|16272380|ref|NP_438593.1| NADH pyrophosphatase [Haemophilus influenzae Rd KW20]
MKILQQDDFGYWLLTQGSNLYLVNNELPFGIAKDIDLEGLQAMQIGEWKNYPLWLVAEQESDEREYVSLS
NLLSLPEDEFHILSRGVEINHFLKTHKFCGKCGHKTQQTQDELAVQCIHCGYQTYPVICPSIIVAVRRGH
EILLANHKRHYSPNGGIYTTLAGFVEVGETFEQAVQREVFEETGISIKNLRYFGSQPWAFPNSQMVGFLA
DYESGEITLQESEIHDAQWFSYDQPLPELPPTGTIARKLIHVTLELCKAEHKCD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nudC mutant is attenuated in rats (Herbert et al., 2002).
COG COG2816L, under L: Replication, recombination and repair
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].