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alaS

Victor ID 2867
Gene Name alaS
Sequence Strain (Species/Organism) Haemophilus influenzae Rd KW20
NCBI Gene ID 950776
NCBI Protein GI 16272755
Locus Tag HI0814
Genbank Accession L42023
Protein Accession NP_438974
Other Database IDs UniProtKB-ID: SYA_HAEIN
UniRef100: UniRef100_P43815
UniRef90: UniRef90_Q4QM86
UniRef50: UniRef50_Q1LTQ4
UniParc: UPI00000512C4
EMBL: L42023
EMBL-CDS: AAC22473.1
RefSeq_NT: NC_000907.1
GenomeReviews: L42023_GR
KEGG: hin:HI0814
NMPDR: fig|71421.1.peg.782
TIGR: HI_0814
HOGENOM: HBG354397
OMA: TLMFTNS
ProtClustDB: PRK00252
BioCyc: HINF71421:HI_0814-MONOMER
Taxonomy ID 71421
Gene Starting Position 863519
Gene Ending Position 866143
Gene Strand (Orientation) -
Protein Name alanyl-tRNA synthetase
Protein pI 6.14
Protein Weight 90051.94
Protein Length 874
Protein Note Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
DNA Sequence 
>gi|16271976:863519-866143 Haemophilus influenzae Rd KW20 chromosome, complete genome
ACTACAGATTTTTGTTTAACCAGTCTTGTGCTACTTTAATTGCTTGTGTCACATTTTCTAGTTGGGAACC
TCCTGCCATTGCCATATCTGGACGACCACCGCCTTTTCCTCCAACTTGTTGAGCCATTAAATTAACAAGT
TCTCCAGCTTTTATTTTGGCGGTTAGATCATTTGTCACTCCAACGACGAGATTAACTTTTTCATCTAATA
TTGATGCAAATGCAATTACGCCTGATCCGAGTTGATTTTTTAAATCATCGACCATTACGCGTAATGATTT
TGTTTCTATACCATCTAATTGTTGTGCGATAACAGAAACACCATTGATTTTTACCGCACTTTTTACAAAA
TAAGAACCTGCCTGCATTGCGGCTTTTTCTTTTAGACCTTGCAATTCTTTTTCCACTTTCTTCGCTTTGT
CTTGAAGTTGCTGGATTTTTTCCGCTAAGGTATTTACGTCTGATTTTAATAAGTCTGCGCTTTGGGTCAG
AATGCGTTGTTGATTATGTAACCAGTCAATGGCATTTTGACCTGTTACAGCTTCAATACGACGAATGCCT
GCAGCCACTGCGTTTTCAGTAATAATTTTAAATAAACCAATATCGCCTGTGCGTTTTGCGTGAATACCGC
CACACAGCTCAATTGAGAAATCGCCCATGGTTAATACACGAACCTTATCGCCATATTTTTCGCCAAAGAG
AGCCATTGCTCCTTTCGCTTTTGCGGAATCAATATCCATAATATCTGTTTGAACTGGAAAGTTAGCGCGG
ATTTTTTGGTTTACTAATGTTTCAATTTCACTCAATTGCTCTTTGGTAATGGCTTCTGGTTGCGCAAAGT
CAAAACGTAAGGCTTTATCTGAAACAAGCGAACCTTTTTGCACAACGTGTAAACCTAGAATTTGACGTAA
GGCAGCGTGCAATAAGTGTGTCGCTGAGTGATTGAGTGATGTGTTGTGGCGACGTTTAGCATCCACAATC
GCATTCACTGATTGTCCAACTTTCAAACTTCCTTGCGTTAATTCTCCAATGTGTCCAAATACTTGCCCAT
ATTTTTGGGTATCTTTCACATTAAAGGTTACACTTTGTGTGCTTAAATATCCGCTATCGCCAATCTGACC
ACCTGATTCTGCATAAAATGGCGTATTTTCTAAAATAACGACCGCACTTTGACCTGCTTCGATACTTTCC
ACTGATTTACCATCATAGAAAAGTGCGGTAATTTTTGCCTGAGATTCTACTTCAGTATAGCCTTCAAACT
TAGTTTCGCCATCTACACGAATAACGCTGTTGTAGTCCACACCAAACTGGCTCGCTGCTTGAGCACGAGT
ACGTTGCGCTTCCATTTTACGGTCAAACGCTTGTTCATCAATAGTAATATTGCGCTCACGACATACATCA
GCCGTTAAATCCAATGGGAAACCATAAGTATCATAAAGTTTGAATGCAACTTCACCTGAAAGAATGCCAT
CTTTCACTTGAGAAAGGGCTTCATCTAATAAGCTCAACCCACGTTCTAGAGTGCGAGCAAATTGTTCTTC
TTCTAGACGTAATAGTTTTTCAACATTTGTTTGTTTTGCTTTTACATCTTTTCCAGCTTCAGCCATTACA
TCAATTAGAGTTGGCACGAGTTTATAGAAAAAAGATTCTTTAGCACCTAATAGGTGACCGTGACGAACTG
CGCGGCGAATAATACGACGTAAGACATAACCACGCCCTTCATTTGATGGGATAACGCCATCGGCGATTAA
ATATGCACAAGAACGAATATGGTCAGCAATAACACGTAGTGATTTGTTAGTTAAATCTGTTGCGCCTACA
ATTTCCGCCGTTTTTGCGATTAATGTTTTGAAAATATCAATCTCGTAGTTTGAGTTCACATGTTGCAACA
CAGCAGAAATACGCTCTAAACCCATACCTGTATCAACAGACGGACGAGGTAATTTTTCCATTGTGCCATC
TGCTAAACGGTTGAACTGCATAAACACAACGTTCCAGATTTCAATATAACGGTCGCCATCTTCTTCTGGT
GAGCCTGGAGGCCCGCCCCAAATATGATCGCCGTGATCGTAGAAAATTTCAGTACAAGGACCGCAAGGAC
CTGTGTCGCCCATTGCCCAGAAGTTGTCTGATGCGTAAGGTGAGCCTTTATTGTCACCAATGCGAATAAT
GCGTTCAGCAGGAACACCAACATCTTTATTCCAAATATTATAGGCTTCGTCGTCAGTTTCATACACGGTT
ACCCAGAGTTTTTCTTTAGGTAAACCAAGCCATTGTGGAGAAGTTAAATATTCCCAAGCAAAATTAATGG
CATCCTGTTTAAAGTAATCACCAAAACTGAAGTTACCGAGCATTTCAAAGAAAGTATGGTGACGTGCGGT
ATAACCAACATTTTCTAAGTCGTTATGCTTACCACCAGGACGTACGCAACGTTGCGCGGTGGTGGCTCGA
GAATAAGGGCGTTTATCCATTCCAAGGAACACATCCTTAAATTGGTTCATCCCAGCGTTCGTGAAAAGCA
AAGTCGGATCATTTTCCGGCACAAGTGAGCTACTCTCAACTACTTGGTGACCTTTGCTATGGAAAAAATC
AAGGAATGATTGTCTTATTTCTGCTGTTGTTTTCA
Protein Sequence 
>gi|16272755|ref|NP_438974.1| alanyl-tRNA synthetase [Haemophilus influenzae Rd KW20]
MKTTAEIRQSFLDFFHSKGHQVVESSSLVPENDPTLLFTNAGMNQFKDVFLGMDKRPYSRATTAQRCVRP
GGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKQDAINFAWEYLTSPQWLGLPKEKLWVTVYETDDEAYN
IWNKDVGVPAERIIRIGDNKGSPYASDNFWAMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEI
WNVVFMQFNRLADGTMEKLPRPSVDTGMGLERISAVLQHVNSNYEIDIFKTLIAKTAEIVGATDLTNKSL
RVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGHLLGAKESFFYKLVPTLIDVMAEAGKDVKA
KQTNVEKLLRLEEEQFARTLERGLSLLDEALSQVKDGILSGEVAFKLYDTYGFPLDLTADVCRERNITID
EQAFDRKMEAQRTRAQAASQFGVDYNSVIRVDGETKFEGYTEVESQAKITALFYDGKSVESIEAGQSAVV
ILENTPFYAESGGQIGDSGYLSTQSVTFNVKDTQKYGQVFGHIGELTQGSLKVGQSVNAIVDAKRRHNTS
LNHSATHLLHAALRQILGLHVVQKGSLVSDKALRFDFAQPEAITKEQLSEIETLVNQKIRANFPVQTDIM
DIDSAKAKGAMALFGEKYGDKVRVLTMGDFSIELCGGIHAKRTGDIGLFKIITENAVAAGIRRIEAVTGQ
NAIDWLHNQQRILTQSADLLKSDVNTLAEKIQQLQDKAKKVEKELQGLKEKAAMQAGSYFVKSAVKINGV
SVIAQQLDGIETKSLRVMVDDLKNQLGSGVIAFASILDEKVNLVVGVTNDLTAKIKAGELVNLMAQQVGG
KGGGRPDMAMAGGSQLENVTQAIKVAQDWLNKNL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: alaS mutant is attenuated in rats (Herbert et al., 2002).
COG COG0013J, under J: Translation, ribosomal structure and biogenesis
References
Herbert et al., 2002: Herbert MA, Hayes S, Deadman ME, Tang CM, Hood DW, Moxon ER. Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microbial pathogenesis. 2002; 33(5); 211-223. [PubMed: 12473436].