| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
pCJ01p4 |
Campylobacter jejuni |
4362678
|
|
115534244
|
pCJ01p4 |
AF301164 |
YP_783826 |
hypothetical protein |
Virulence factor |
MUTATION: Mutation of plasmid gene ORF3 (comB3) reduced adherence/invasion of INT407 cells to approximately 1/3 of wild type strain 81-176 [Ref6227:Bacon et al., 2000].
|
10899834
|
|
|
Cj0019c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904357
|
|
218561712
|
Cj0019c |
AL111168 |
YP_002343491 |
putative MCP-domain signal transduction protein |
Virulence factor |
MUTATION: a Cj0019c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0020c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904360
|
|
218561713
|
Cj0020c |
AL111168 |
YP_002343492 |
cytochrome C551 peroxidase |
Virulence factor |
MUTATION: a Cj0020c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
fliA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904393
|
|
218561746
|
Cj0061c |
AL111168 |
YP_002343525 |
flagellar biosynthesis sigma factor |
Virulence factor |
MUTATION: fliA mutants showed reduced motility (25% that of the wild type) and did not colonize a chicken cecum [Ref6406:Fernando et al., 2007] |
17761334
|
|
|
Cj0248 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904574
|
|
218561911
|
Cj0248 |
AL111168 |
YP_002343690 |
hypothetical protein |
Virulence factor |
MUTATION: a Cj0248 C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
motB from Campylobacter jejuni subsp. jejuni NCTC 11168 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904660
|
|
15791704
|
Cj0336c |
|
NP_281527.1 |
flagellar motor protein MotB |
Virulence factor |
MUTATION: a Cj0336c mutant C. jejuni was attenuated for colonization of the chicken caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
motA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904661
|
|
218561996
|
Cj0337c |
AL111168 |
YP_002343775 |
flagellar motor protein MotA |
Virulence factor |
MUTATION: a Cj0337c C. jejuni mutant was attenuated for colonization of the chicken caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0415 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904739
|
|
218562073
|
Cj0415 |
AL111168 |
YP_002343852 |
putative GMC oxidoreductase subunit |
Virulence factor |
MUTATION: a cj0415 mutant was impaired in establishing chicken colonization [Ref6407:Pajaniappan et al., 2008] |
18284594
|
|
|
Cj0454c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904777
|
|
218562109
|
Cj0454c |
AL111168 |
YP_002343888 |
hypothetical protein |
Virulence factor |
MUTATION: a Cj0454c C. jejuni mutant was attenuated for colonziation of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0456c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904779
|
|
218562111
|
Cj0456c |
AL111168 |
YP_002343890 |
hypothetical protein |
Virulence factor |
MUTATION: a Cj0456c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0618 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904945
|
|
218562269
|
Cj0618 |
AL111168 |
YP_002344048 |
hypothetical protein |
Virulence factor |
MUTATION: a Cj0618 C. jejuni mutant was attenuated for the colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0629 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904959
|
|
15791989
|
Cj0629 |
|
NP_281812 |
lipoprotein |
Virulence factor |
MUTATION: Cj0629 (capA) mutant had a significantly reduced capacity for association with and invasion of Caco-2 cells and failed to colonize and persist in chickens [Ref6408:Ashgar et al., 2007]. |
17172331
|
|
|
rpoN |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
904991
|
|
218562314
|
Cj0670 |
AL111168 |
YP_002344093 |
RNA polymerase factor sigma-54 |
Virulence factor |
MUTATION: rpoN mutant cells lacked the spiral shape of C. jejuni and motility was reduced to 10% of the wild-type, mutants also showed significant colonization defects of a chicken cecum [Ref6406:Fernando et al., 2007] |
17761334
|
|
|
pta |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905007
|
|
218562327
|
Cj0688 |
AL111168 |
YP_002344106 |
putative phosphate acetyltransferase |
Virulence factor |
MUTATION: a Cj0688 C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
flaC |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905038
|
|
218562359
|
Cj0720c |
AL111168 |
YP_002344138 |
flagellin |
Virulence factor |
MUTATION: Invasion of HEp-2 cells by flaC null mutants was reduced to a level of 14% compared with wild type [Ref6409:Song et al., 2004] |
15228533
|
|
|
Cj0903c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905201
|
|
218562523
|
Cj0903c |
AL111168 |
YP_002344302 |
putative amino-acid transport protein |
Virulence factor |
MUTATION: a Cj0903c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
ciaB from Campylobacter jejuni subsp. jejuni NCTC 11168 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905214
|
|
218562533
|
Cj0914c |
AL111168 |
YP_002344312 |
CiaB protein |
Virulence factor |
MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization [Ref6410:Konkel et al., 1999] |
10361274
|
|
|
aas |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905232
|
|
218562557
|
Cj0938c |
AL111168 |
YP_002344336 |
2-acyl-glycerophospho-ethanolamine acyltransferase |
Virulence factor |
MUTATION: a Cj0938c (aas) C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
Cj0977 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905268
|
|
218562593
|
Cj0977 |
AL111168 |
YP_002344372 |
hypothetical protein |
Virulence factor |
MUTATION: A Cj0977 mutant strain is fully motile but significantly reduced in the invasion of intestinal epithelial cells in vitro [Ref6411:Yokoyama et al., 2008] |
18835274
|
|
|
livJ |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905311
|
|
218562635
|
Cj1019c |
AL111168 |
YP_002344414 |
branched-chain amino-acid ABC transporter periplasmic binding protein |
Virulence factor |
MUTATION: a Cj1019c (livJ) C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
cheY from Campylobacter jejuni subsp. jejuni NCTC 11168 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905409
|
|
15792443
|
Cj1118c |
|
NP_282266.1 |
chemotaxis regulatory protein |
Virulence factor |
MUTATION: a Cj1118c (cheY) C. jejuni mutant was attenuated for the colonization of chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
pglF |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905411
|
|
218562734
|
Cj1120c |
AL111168 |
YP_002344513 |
UDP-GlcNAc C4,6 dehydratase |
Virulence factor |
MUTATION: a Cj1120c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
pglE from Campylobacter jejuni subsp. jejuni NCTC 11168 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905412
|
|
218562735
|
Cj1121c |
HC990639 |
YP_002344514 |
UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase |
Virulence factor |
MUTATION: a cj1121c knock-out mutant is impaired for flagella-mediated motility, for invasion of intestinal epithelial cells, and for persistence in the chicken intestine (Vijayakumar et al., 2006) |
|
|
|
pglH from Campylobacter jejuni subsp. jejuni NCTC 11168 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905420
|
|
218562743
|
Cj1129c |
AL111168 |
YP_002344522 |
GalNAc transferase/polymerase |
Virulence factor |
MUTATION: a Cj1129c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
fliR |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905469
|
|
218562791
|
Cj1179c |
AL111168 |
YP_002344570 |
flagellar biosynthesis protein FliR |
Virulence factor |
MUTATION: a Cj1179c C. jejuni mutant was attenuated for colonization of the chick caeca [Ref6405:Hendrixson and DiRita, 2004] |
15066034
|
|
|
dccR |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905513
|
|
218562835
|
Cj1223c |
AL111168 |
YP_002344614 |
two-component regulator |
Virulence factor |
MUTATION: A DeltadccR (Delta Cj1223c) response regulator mutant exhibited significantly reduced colonization of immunocompetent limited flora (I-LF) mice [Ref6412:MacKichan et al., 2004] |
15554967
|
|
|
hspR |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905521
|
|
218562842
|
Cj1230 |
AL111168 |
YP_002344621 |
heat shock transcriptional regulator |
Virulence factor |
MUTATION: hspR mutant was unable to form colonies at 44 degrees C [Ref6413:Andersen et al., 2005] |
15758235
|
|
|
dnaJ |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905551
|
|
218562872
|
Cj1260c |
AL111168 |
YP_002344651 |
chaperone protein DnaJ |
Virulence factor |
MUTATION: a C. jejuni DnaJ mutant was unable to colonize newly hatched Leghorn chickens [Ref6414:Konkel et al., 1998] |
9673247
|
|
|
Cj1279c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905570
|
|
218562891
|
Cj1279c |
AL111168 |
YP_002344670 |
putative fibronectin domain-containing lipoprotein |
Virulence factor |
MUTATION: Cj1279c mutants had a significantly reduced adherence to chicken epithelial cells [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
pseA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905608
|
|
218562927
|
Cj1316c |
AL111168 |
YP_002344706 |
pseudaminic acid biosynthesis PseA protein |
Virulence factor |
MUTATION: Mutation of Cj1316c or pseA had been shown to result in loss of PseAm. C jejuni that produced flagella lacking PseAm failed to autoagglutinate. Mutants (81-176) defective in autoagglutination showed a modest reduction in adherence and invasion of INT407 cells [Ref6416:Guerry et al., 2006] |
16573682
|
|
|
Cj1321 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905613
|
|
218562932
|
Cj1321 |
AL111168 |
YP_002344711 |
putative transferase |
Virulence factor |
MUTATION: colonization of chick ceca by a Δ(Cj1321-Cj1325/6) mutant was reduced [Ref6417:Howard et al., 2009] |
19307210
|
|
|
Cj1322 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905614
|
|
218562933
|
Cj1322 |
AL111168 |
YP_002344712 |
hypothetical protein |
Virulence factor |
MUTATION: colonization of chick ceca by a Δ(Cj1321-Cj1325/6) mutant was reduced (Howard et al., 2009) |
|
|
|
Cj1323 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905615
|
|
218562934
|
Cj1323 |
AL111168 |
YP_002344713 |
hypothetical protein |
Virulence factor |
MUTATION: colonization of chick ceca by a Δ(Cj1321-Cj1325/6) mutant was reduced (Howard et al., 2009) |
|
|
|
Cj1324 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905616
|
|
218562935
|
Cj1324 |
AL111168 |
YP_002344714 |
hypothetical protein |
Virulence factor |
MUTATION: A motile ΔCj1324 mutant with intact flagella was considerably less hydrophobic, less able to autoagglutinate and form biofilms, and less able to colonize chickens than the parent strain [Ref6417:Howard et al., 2009] |
19307210
|
|
|
Cj1325 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905617
|
|
218562936
|
Cj1325 |
AL111168 |
YP_002344715 |
putative methyltransferase |
Virulence factor |
MUTATION: colonization of chick ceca by a Δ(Cj1321-Cj1325/6) mutant was reduced (Howard et al., 2009) |
|
|
|
Cj1326 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905618
|
|
15792649
|
Cj1326 |
|
NP_282472 |
hypothetical protein |
Virulence factor |
MUTATION: colonization of chick ceca by a Δ(Cj1321-Cj1325/6) mutant was reduced (Howard et al., 2009) |
|
|
|
flaB |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905630
|
|
218562947
|
Cj1338c |
AL111168 |
YP_002344726 |
flagellin |
Virulence factor |
MUTATION: nonflagellated, nonmotile (flaA flaB Mot-) mutants of C. jejuni had a 30%-40% decrease in INT 407 cell internalization (Grant et al., 1993) |
|
|
|
flaA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905631
|
|
218562948
|
Cj1339c |
AL111168 |
YP_002344727 |
flagellin |
Virulence factor |
MUTATION: nonflagellated, nonmotile (flaA flaB Mot-) mutants of C. jejuni had a 30%-40% decrease in INT 407 cell internalization [Ref6418:Grant et al., 1993] |
8478066
|
|
|
Cj1349c |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905641
|
|
218562958
|
Cj1349c |
AL111168 |
YP_002344737 |
putative fibronectin/fibrinogen-binding protein |
Virulence factor |
MUTATION: Cj1349c mutants had a significantly reduced ability to colonize chicken epithelial cells [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
pldA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905643
|
|
218562960
|
Cj1351 |
AL111168 |
YP_002344739 |
phospholipase A |
Virulence factor |
MUTATION: a mutation in the pldA gene impairs the ability of C. jejuni to colonize the cecum [Ref6419:Ziprin et al., 2001] |
11569726
|
|
|
Cj1461 |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905749
|
|
218563064
|
Cj1461 |
AL111168 |
YP_002344843 |
putative DNA methylase |
Virulence factor |
MUTATION: A Deltacj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type [Ref6420:Kim et al., 2008] |
18689478
|
|
|
flgK |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905754
|
|
218563069
|
Cj1466 |
AL111168 |
YP_002344848 |
flagellar hook-associated protein FlgK |
Virulence factor |
MUTATION: a flgK mutant of C. jejuni expressing only the hook filament junction protein showed diminished motility and was completely attenuated for cecal colonization in chickens [Ref6406:Fernando et al., 2007] |
17761334
|
|
|
pflA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905864
|
|
218563154
|
Cj1565c |
AL111168 |
YP_002344934 |
paralysed flagellum protein |
Virulence factor |
MUTATION: a Cj1565c C. jejuni mutant was attenuated for colonization of the chick caeca |
|
|
|
sdaA |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
905896
|
|
218563213
|
Cj1624c |
AL111168 |
YP_002344993 |
L-serine dehydratase |
Virulence factor |
MUTATION: sdaA mutants completely failed to colonize 3-week-old chickens as assayed both by cloacal swabs taken over a 6-week period and by cecal colony counts postmortem [Ref6421:Velayudhan et al., 2004] |
14688104
|
|
|
peb1A |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
906008
|
|
218562540
|
Cj0921c |
AL111168 |
YP_002344319 |
bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein |
Virulence factor |
MUTATION: reduced adherence to epithelial cells, attenuated in mice [Ref6422:Pei et al., 1998]. |
9488379
|
|
|
ciaB from Campylobacter jejuni RM1221 |
Campylobacter jejuni RM1221 |
3231503
|
|
57237742
|
CJE0992 |
|
YP_178990.1 |
invasion antigen B |
Virulence factor |
MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization (Konkel et al., 1999) |
|
|
|
CJE0997 |
Campylobacter jejuni RM1221 |
3231508
|
|
57237747
|
CJE0997 |
CP000025 |
YP_178995 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEP1 mutants had a significantly reduced in vivo colonization of broiler chicks [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
CJE0998 |
Campylobacter jejuni RM1221 |
3231509
|
|
57237748
|
CJE0998 |
CP000025 |
YP_178996 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chicks [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
pebC from Campylobacter jejuni RM1221 |
Campylobacter jejuni RM1221 |
3231511
|
|
57237750
|
CJE1000 |
|
YP_178998.1 |
amino acid ABC transporter, ATP-binding protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colinization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
jlpA from Campylobacter jejuni RM1221 |
Campylobacter jejuni RM1221 |
3231574
|
|
57237810
|
CJE1065 |
|
YP_179058.1 |
surface-exposed lipoprotein |
Virulence factor |
MUTATION: adherence of deletion mutants of jlpA to HEp-2 epithelial cells was reduced compared with that of parental C. jejuni [Ref6423:Jin et al., 2001] |
11251839
|
|
|
pglH from Campylobacter jejuni RM1221 |
Campylobacter jejuni RM1221 |
3231778
|
|
57238010
|
CJE1271 |
|
YP_179259.1 |
general glycosylation pathway protein |
Virulence factor |
MUTATION: reduce ability to adhere to human epithelial Caco-2 cells [Ref6424:Karlyshev et al., 2004]. |
15184581
|
|
|
pebC from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4682094
|
|
121612723
|
CJJ81176_0929 |
|
YP_001000596.1 |
amino acid ABC transporter, ATP-binding protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
motB from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4682104
|
|
121612816
|
CJJ81176_0358 |
|
YP_001000046.1 |
flagellar motor protein MotB |
Virulence factor |
MUTATION: A motB insertion-deletion mutant failed to establish colonization in LF mice [Ref6587:Chang and Miller, 2006] |
16926420
|
|
|
cheY from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4682456
|
|
121613202
|
CJJ81176_1136 |
|
YP_001000796.1 |
chemotaxis protein CheY |
Virulence factor |
MUTATION: Insertional inactivation of the cheY gene in 81-176 resulted in an approx. threefold increase in adherence and invasion in vitro, but this strain was unable to colonize or cause disease in animals [Ref6588:Yao et al., 1997] |
9076738
|
|
|
cheA |
Campylobacter jejuni subsp. jejuni 81-176 |
4682610
|
|
121613274
|
CJJ81176_0310 |
CP000538 |
YP_999998 |
chemotaxis protein CheA |
Virulence factor |
MUTATION: A cheA insertion-deletion mutant failed to establish colonization in LF mice [Ref6587:Chang and Miller, 2006] |
16926420
|
|
|
jlpA from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4682683
|
|
121613448
|
CJJ81176_1002 |
|
YP_001000663.1 |
surface-exposed lipoprotein |
Virulence factor |
MUTATION: adherence of deletion mutants of jlpA to HEp-2 epithelial cells was reduced compared with that of parental C. jejuni [Ref6423:Jin et al., 2001] |
11251839
|
|
|
ciaB from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4682759
|
|
121612338
|
CJJ81176_0921 |
|
YP_001000588.1 |
invasion antigen B |
Virulence factor |
MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization (Konkel et al., 1999) |
|
|
|
pglB |
Campylobacter jejuni subsp. jejuni 81-176 |
4682880
|
|
121612188
|
CJJ81176_1143 |
NZ_AASL01000001 |
YP_001000803 |
general glycosylation pathway protein |
Virulence factor |
MUTATION: pglB impaired in glycosylation showed reduced ability to adhere to INT407 cells and colonize in mice [Ref6589:Szymanski et al., 2002]. |
11895996
|
|
|
CJJ81176_0927 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683249
|
|
121612211
|
CJJ81176_0927 |
NZ_AASL01000001 |
YP_001000594 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
kpsC |
Campylobacter jejuni subsp. jejuni 81-176 |
4683284
|
|
121612738
|
CJJ81176_1413 |
NZ_AASL01000001 |
YP_001001069 |
capsule polysaccharide export protein KpsC |
Virulence factor |
MUTATION: kpsC mutants were defective in colonization and virulence [Ref6590:Grant et al., 2005] |
16332783
|
|
|
CJJ81176_1165 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683357
|
|
121613507
|
CJJ81176_1165 |
AY423899 |
YP_001000825 |
LPS glycosyltransferase subfamily protein |
Virulence factor |
MUTATION: knockout strains showed reduced ability to invade epithelial cells [Ref6591:Louwen et al., 2008]. |
18644887
|
|
|
fliI |
Campylobacter jejuni subsp. jejuni 81-176 |
4683388
|
|
121613240
|
CJJ81176_0226 |
NZ_AASL01000001 |
YP_999914 |
flagellum-specific ATP synthase |
Virulence factor |
MUTATION: A flil insertion-deletion mutant failed to establish colonization in LF mice [Ref6587:Chang and Miller, 2006] |
16926420
|
|
|
ggt from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683465
|
|
121613257
|
CJJ81176_0067 |
|
YP_999755.1 |
gamma-glutamyltransferase |
Virulence factor |
MUTATION: mutations in ggt showed it to be required for persistent colonization of the avian gut [Ref6592:Barnes et al., 2007] |
17600669
|
|
|
cadF |
Campylobacter jejuni subsp. jejuni 81-176 |
4683585
|
|
121612147
|
CJJ81176_1471 |
NZ_AASL01000001 |
YP_001001127 |
fibronectin-binding protein |
Virulence factor |
MUTATION: cadF mutants had reduced binding to immobilized Fn as compared to wt strains [Ref6593:Monteville et al., 2003] |
12576589
|
|
|
pglH from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683595
|
|
121613657
|
CJJ81176_1146 |
|
YP_001000806.1 |
general glycosylation pathway protein |
Virulence factor |
MUTATION: reduce ability to adhere to human epithelial Caco-2 cells [Ref6424:Karlyshev et al., 2004]. |
15184581
|
|
|
CJJ81176_0926 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683648
|
|
121613743
|
CJJ81176_0926 |
NZ_AASL01000001 |
YP_001000593 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
pglE from Campylobacter jejuni subsp. jejuni 81-176 |
Campylobacter jejuni subsp. jejuni 81-176 |
4683652
|
|
121612710
|
CJJ81176_1139 |
AF108897 |
YP_001000799 |
general glycosylation pathway protein |
Virulence factor |
MUTATION: knockout mutant impaired for flagella-mediated motility and invasion of intestinal epithelial cells [Ref6594:Vijayakumar et al., 2006]. |
16690622
|
|
|
JJD26997_0895 |
Campylobacter jejuni subsp. doylei 269.97 |
5388635
|
|
153952480
|
JJD26997_0895 |
CP000768 |
YP_001398011 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
jlpA from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5388922
|
|
153952037
|
JJD26997_0805 |
|
YP_001397934.1 |
surface-exposed lipoprotein |
Virulence factor |
MUTATION: adherence of deletion mutants of jlpA to HEp-2 epithelial cells was reduced compared with that of parental C. jejuni [Ref6423:Jin et al., 2001] |
11251839
|
|
|
pebC from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5389528
|
|
153951397
|
JJD26997_0892 |
|
YP_001398008.1 |
amino acid ABC transporter, ATP-binding protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
pebA from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5389725
|
|
153952077
|
JJD26997_0893 |
|
YP_001398009.1 |
amino acid ABC transporter, periplasmic amino acid-binding protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
ciaB from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5390001
|
|
153952319
|
JJD26997_0900 |
|
YP_001398016.1 |
invasion antigen B |
Virulence factor |
MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization (Konkel et al., 1999) |
|
|
|
JJD26997_0894 |
Campylobacter jejuni subsp. doylei 269.97 |
5390171
|
|
153951698
|
JJD26997_0894 |
CP000768 |
YP_001398010 |
amino acid ABC transporter, permease protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
ggt from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5390397
|
|
153951153
|
JJD26997_0042 |
|
YP_001397302.1 |
gamma-glutamyltransferase |
Virulence factor |
MUTATION: mutations in ggt showed it to be required for persistent colonization of the avian gut (Barnes et al., 2007) |
|
|
|
pglH from Campylobacter jejuni subsp. doylei 269.97 |
Campylobacter jejuni subsp. doylei 269.97 |
5390593
|
|
153951965
|
JJD26997_0592 |
|
YP_001397761.1 |
general glycosylation pathway protein |
Virulence factor |
MUTATION: reduce ability to adhere to human epithelial Caco-2 cells [Ref6424:Karlyshev et al., 2004]. |
15184581
|
|
|
racR |
Campylobacter jejuni subsp. jejuni 81116 |
5617154
|
|
157415525
|
C8J_1205 |
CP000814 |
YP_001482781 |
DNA-binding response regulator |
Virulence factor |
MUTATION: A mutation of the response regulator gene racR reduced the organism's ability to colonize the chicken intestinal tract [Ref6596:Brás et al., 1999] |
10322038
|
|
|
C8J_0850 |
Campylobacter jejuni subsp. jejuni 81116 |
5617830
|
|
157415170
|
C8J_0850 |
CP000814 |
YP_001482426 |
invasion antigen B |
Virulence factor |
MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization (Konkel et al., 1999) |
|
|
|
pebA from Campylobacter jejuni subsp. jejuni 81116 |
Campylobacter jejuni subsp. jejuni 81116 |
5618176
|
|
157415178
|
C8J_0858 |
|
YP_001482434.1 |
amino acid ABC transporter, periplasmic amino acid-binding protein PEB1 |
Virulence factor |
MUTATION: PEB1 mutants had a significantly reduced in vivo colonization of broiler chickens [Ref6415:Flanagan et al., 2009] |
19349427
|
|
|
LPS |
Campylobacter jejuni |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: A galE mutant which expressed a lipid A-core molecule of reduced molecular weight that did not react with antiserum raised against the parental strain. The galE mutant also showed a reduction in its ability to adhere to and invade INT407 cells [Ref7297:Fry et al., 2000]. |
10768949
|
|
|
kpsM |
Campylobacter jejuni subsp. jejuni 81-176 |
4683743
|
|
121613575
|
CJJ81176_1441 |
CP000538 |
YP_001001097 |
capsular polysaccharide ABC transporter, permease protein |
Virulence factor |
MUTATION: kpsM mutant is significantly reduced in invasion of INT407 cells and reduced in virulence in a ferret diarrhoeal disease model [Ref7300:Bacon et al., 2001]. |
11359581
|
|
|
kpsE |
Campylobacter jejuni subsp. jejuni 81116 |
5617759
|
|
157415671
|
C8J_1352 |
CP000814 |
YP_001482927 |
capsular polysaccharide ABC transporter |
Virulence factor |
MUTATION: the capacity of a kpsE mutant to adhere to the INT-407 cells was reduced 20-fold, and the invasion capability of the kpsE mutant was two-fold lower than that of the wild type [Ref7301:Bachtiar et al., 2007]. |
17266722
|
