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ciaB from Campylobacter jejuni subsp. jejuni NCTC 11168

Victor ID 817
Gene Name ciaB from Campylobacter jejuni subsp. jejuni NCTC 11168
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905214
NCBI Protein GI 218562533
Locus Tag Cj0914c
Genbank Accession AL111168
Protein Accession YP_002344312
Other Database IDs UniProtKB-ID: Q0P9Y5_CAMJE
UniRef100: UniRef100_A3ZI91
UniRef90: UniRef90_A1VZP7
UniRef50: UniRef50_A7ZFI0
UniParc: UPI00000C1D8D
EMBL: AL111168
EMBL-CDS: CAL35034.1
RefSeq_NT: NC_002163.1
GenomeReviews: AL111168_GR
KEGG: cje:Cj0914c
HOGENOM: HBG320874
OMA: QVVPNDE
ProtClustDB: CLSK878990
BioCyc: CJEJ192222:CJ0914C-MONOMER
Taxonomy ID 192222
Gene Starting Position 849833
Gene Ending Position 851665
Gene Strand (Orientation) -
Protein Name CiaB protein
Protein pI 5.17
Protein Weight 70469.64
Protein Length 610
Protein Note Original (2000) note: Cj0914c, ciaB, unknown function, len: 610 aa; no Hp match. Product is translocated into host cells. Mutants fail to translocate,and fail to translocate other proteins. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature~Updated (2006) note: Papers attached giving further information regarding this CDS. Functional classification - Pathogenicity~PMID:10361274, PMID:10540297, PMID:10659361,PMID:15722140
DNA Sequence 
>gi|15791399:849833-851665 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
ATTATTTTTTCTTATATCTTTCAAATTCTCCACTATTATCAATTTCATTACCAATTTTCTCGTATAAATC
ATAATAAAATTTAACAAATTCTTTACACTTAGGCATAATAGGAAGAAAAATATTATCTTCAATTTCACAA
AATCTACTTAAAAACTCTTTTGCATCAAGTCTTAAAGCATAGTGTTTTGCCAATTCATGATAATTTTTTA
AAGTTAGCTCTTTAAATTTTTCATAATACCCTAAATCAAAATTTATCTTCAAATTATTATTTTCAAAAAT
CAATACTTCGCTTTCAAAAAGCAAGCTAAGATGAATAAGTCCTTCCGTATAATAAGGTCTAACTTCATCA
ACCCTTTGCCAAGAAATAAGTCCAATAGCTCTTTTTATAAGTTCATGAAAAACAGGCATTATCAAGTCAT
CTTGTTCATGATAAAAGAAATTTATAAGTCCACCTGTAGTAGCTTTATATTCTTCTATATTTTTAAAAAA
ACCACTCTGATTCATTGTTTTTTCGGTATCATTAGCAATAAAAAATATATGACCAAATTCATGGCCTATA
GTTGATACTTCATAAACCCTTTTCCAAATTTTTTCCTGATAAAATAAAATATTTCTTCCAAAATCCAAAA
ATTCTTTATCAAAAACCTCGCTAGAAATTTTCATAAAAGGCTTTGTTTTAGCATTTTCATATACAAAATT
TATAAAGGCAAATATTTTTTTGCCCGCCTTAGAACTTACAAACTCATCATTTGGAACGACTTGAGCTGAG
AATAAACCTTTAAGTTCAGCACCATAAAATATCATCGGAGTGCAAATATAAAGTTGAGTTTTTTCTATAT
TAGATAAAACTTCTTTTTCTAATTCACAATCTTCAAGTCCTATATTTTTATAAACATGTTCAAAACTTTC
CTTAATTTCATTACCAAATTTCAAAACATCAAAATCATTTTCATCTTCTATTCTTATATCCCATTCTAAT
GCCACCGCATGAGTATAATTATCTTCATAATATTCTAAAGGATGTCCCACTTGTAAAGGTGATTTTACTT
TCATCCAAGCAAATTCAGCTTCTTGCCAAGCTTTTATAACCCTATCTTCATCTTTTTCACAAAACGCTAA
TTTTAATTTTTCAAAATATTCTATATAAGCTTTTTCCTCTTCGCTGCTAGCAAATATTTTAAGCTGATCA
ATCATATTTTCAAAAGCAAATTCTAATTTTAAAATTTCATTCTCGAAAAATCTCGCATAAGGAACAAATT
TCCATAAATTTCCTATTCTAACTAAAACACCATAGCTTCGCTCACAAATTTCTCCTTCTGGAGTTTTTTG
ATATAAATGATTTTTACGTAAAAATTCCATTGCATCATCTAAATTTGGAAATTGAGTAGATAAAATTTTA
TTATTTTTTTCTATAATTTCTTTAGTCCAAGAAATTTCAAAAATATTCATAATTAAACCTATATTATGCA
CTCCTTGTATTAAGGACTGATAAAAATTATTTAAAAGTTTTTTCTCTTTTATTTCATTAATTAAATTTTG
ATGTTCTTTTTCATAAAACTTTCTAACCTCTTCATAGAACTTATGTTTTAACTCTATAATCTTATCTTCC
TTAAAGTTGTTTTTTTTCCACTCTTGAACTAAATTTTCTTCTTTTAAATCAATCAAACGCCTAAGTATGG
CTAGCATAGTTGTTTTATCTTGTTTTAACTCACTTAAAGAAATCAAAGATCTAAAATACTCGCCCACATC
TTCTTTGTCTAAAAACTCATATAACGCATTATTTCTTTCTTTGTATTTTCTAACCAATTTAGCTATTTCT
TTAAAATTATTCA
Protein Sequence 
>gi|218562533|ref|YP_002344312.1| CiaB protein [Campylobacter jejuni subsp. jejuni NCTC 11168]
MNNFKEIAKLVRKYKERNNALYEFLDKEDVGEYFRSLISLSELKQDKTTMLAILRRLIDLKEENLVQEWK
KNNFKEDKIIELKHKFYEEVRKFYEKEHQNLINEIKEKKLLNNFYQSLIQGVHNIGLIMNIFEISWTKEI
IEKNNKILSTQFPNLDDAMEFLRKNHLYQKTPEGEICERSYGVLVRIGNLWKFVPYARFFENEILKLEFA
FENMIDQLKIFASSEEEKAYIEYFEKLKLAFCEKDEDRVIKAWQEAEFAWMKVKSPLQVGHPLEYYEDNY
THAVALEWDIRIEDENDFDVLKFGNEIKESFEHVYKNIGLEDCELEKEVLSNIEKTQLYICTPMIFYGAE
LKGLFSAQVVPNDEFVSSKAGKKIFAFINFVYENAKTKPFMKISSEVFDKEFLDFGRNILFYQEKIWKRV
YEVSTIGHEFGHIFFIANDTEKTMNQSGFFKNIEEYKATTGGLINFFYHEQDDLIMPVFHELIKRAIGLI
SWQRVDEVRPYYTEGLIHLSLLFESEVLIFENNNLKINFDLGYYEKFKELTLKNYHELAKHYALRLDAKE
FLSRFCEIEDNIFLPIMPKCKEFVKFYYDLYEKIGNEIDNSGEFERYKKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: C. jejuni ciaB null mutants had a significant reduction in internalization (Konkel et al., 1999)
References
Konkel et al., 1999: Konkel ME, Kim BJ, Rivera-Amill V, Garvis SG. Bacterial secreted proteins are required for the internaliztion of Campylobacter jejuni into cultured mammalian cells. Molecular microbiology. 1999; 32(4); 691-701. [PubMed: 10361274].