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dccR

Victor ID 826
Gene Name dccR
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905513
NCBI Protein GI 218562835
Locus Tag Cj1223c
Genbank Accession AL111168
Protein Accession YP_002344614
Other Database IDs UniProtKB-ID: Q0P933_CAMJE
UniRef100: UniRef100_A1W0K6
UniRef90: UniRef90_A1W0K6
UniRef50: UniRef50_B9KEK9
UniParc: UPI00000C1E72
EMBL: AL111168
EMBL-CDS: CAL35338.1
RefSeq_NT: NC_002163.1
GenomeReviews: AL111168_GR
KEGG: cje:Cj1223c
HOGENOM: HBG753323
OMA: LKIRINA
ProtClustDB: CLSK879148
BioCyc: CJEJ192222:CJ1223C-MONOMER
Taxonomy ID 192222
Gene Starting Position 1152337
Gene Ending Position 1153002
Gene Strand (Orientation) -
Protein Name two-component regulator
Protein pI 4.68
Protein Weight 25135.9
Protein Length 221
Protein Note Original (2000) note: Cj1223c, probable two-component regulator, len: 221 aa; similar to many e.g. CIAR_STRPN transcriptional regulatory protein CIAR (224 aa), fasta scores; opt: 426 z-score: 522.6 E(): 8.2e-22,37.0% identity in 219 aa overlap. 39.4% identity to HP1365. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal~Updated (2006) note: Characterised in Campylobacter jejuni. Literature search identified characterisation paper where Cj1222c and Cj1223c were shown to required for optimal colonization and were termed dccRS (diminished capacity to colonize) two-component system. Functional classification - Signal transduction~PMID:15554967
DNA Sequence 
>gi|15791399:1152337-1153002 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
TTTAGCCATAGCAATATCCCCTGCCTCTTTGATTTATAATTTTTTCTTTTCCTAAAATTTTACGTAAATT
TTTCACATAAGCCCTTAAACTTAGCTCACTAGGCTCCTCATCATAATCCCAGAGTTCTTCAAAAATTCTC
TCTGTACTTAAAAAGTTGTTTTTATTTTTAAGTAATAAAGACAAAAGCTTAATTTCTTTACTCGGTAAAG
TCAAGGCTTTATTATTATGGTAAAGAATTTGTGTAGTAAATTCAAATCTAAATCCATCTCCTAAATCTTC
AAAATCTTCATTTTTATGTGAAAAAGCTCTTTTAAGCAAAGCTTTAACCCTGATAGATAACTCGGCAAGT
TCAAAAGGTTTTTTTATATAATCATCACAACCTGCGTCAAAGCCTTGTTTTAAATCATTTGTTGTGTTTA
AAGAAGTCATGAAAATTGCTGGAGTTTGCTTTCCGCTTTTTCTTAATTCTTTAAGTAATGAAAATCCATC
TCCTAAAGGAACTTTTACATCTAAAATCCAAAGATCAAAATATCTTTCATAAGCCATATCTAAAGCTTCT
TGCGCATTATCGCATAAAAATACTTCATATCCCTCATCGTTTAAAAACTCTTCAATGATCTCACTCAAGC
TCAAATCATCTTCTAAAAGTAAAATTTTAGCAGCCA
Protein Sequence 
>gi|218562835|ref|YP_002344614.1| two-component regulator [Campylobacter jejuni subsp. jejuni NCTC 11168]
MAAKILLLEDDLSLSEIIEEFLNDEGYEVFLCDNAQEALDMAYERYFDLWILDVKVPLGDGFSLLKELRK
SGKQTPAIFMTSLNTTNDLKQGFDAGCDDYIKKPFELAELSIRVKALLKRAFSHKNEDFEDLGDGFRFEF
TTQILYHNNKALTLPSKEIKLLSLLLKNKNNFLSTERIFEELWDYDEEPSELSLRAYVKNLRKILGKEKI
INQRGRGYCYG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A DeltadccR (Delta Cj1223c) response regulator mutant exhibited significantly reduced colonization of immunocompetent limited flora (I-LF) mice (MacKichan et al., 2004)
References
MacKichan et al., 2004: MacKichan JK, Gaynor EC, Chang C, Cawthraw S, Newell DG, Miller JF, Falkow S. The Campylobacter jejuni dccRS two-component system is required for optimal in vivo colonization but is dispensable for in vitro growth. Molecular microbiology. 2004; 54(5); 1269-1286. [PubMed: 15554967].