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flaC

Victor ID 815
Gene Name flaC
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905038
NCBI Protein GI 218562359
Locus Tag Cj0720c
Genbank Accession AL111168
Protein Accession YP_002344138
Other Database IDs UniProtKB-ID: FLAC_CAMJE
UniRef100: UniRef100_P96747
UniRef90: UniRef90_P96747
UniRef50: UniRef50_P96747
UniParc: UPI000012A890
EMBL: U85622
EMBL: AL111168
EMBL-CDS: AAB48473.1
EMBL-CDS: CAL34857.1
RefSeq_NT: NC_002163.1
MINT: MINT-6484790
GenomeReviews: AL111168_GR
KEGG: cje:Cj0720c
HOGENOM: HBG393042
OMA: EVERIGT
ProtClustDB: CLSK878904
BioCyc: CJEJ192222:CJ0720C-MONOMER
Taxonomy ID 192222
Gene Starting Position 676226
Gene Ending Position 676975
Gene Strand (Orientation) -
Protein Name flagellin
Protein pI 4.21
Protein Weight 25513.73
Protein Length 249
Protein Note Original (2000) note: Cj0720c, flaC, flagellin,len: 249 aa; 99.6% identical to TR:P96747 (EMBL: U85622) C. jejuni flaC, and similar to the N-terminus of e.g. FLAB_CAMJE flagellin B (CJ1338) (575 aa), fasta scores; opt: 236 z-score: 261.7 E(): 2.8e-07, 27.2% identity in 202 aa overlap. No Hp ortholog~Updated (2006) note: Pfam domain PF00669 Bacterial flagellin N-terminus identified within CDS. Further support given to product function. Characterised in Campylobacter and Escherichia coli with acceptable identity score. Putative not added to product function. Literature search identified paper linking product function to adhesion and to play an important role in cell adhesion. Functional classification - Surface structures~PMID:15228533, PMID:16740937
DNA Sequence 
>gi|15791399:676226-676975 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
TTTATTGTAATAAATTAGCAATTTTGCTTTGAAGCTGCATGTTGGATTGCGCAGCAACAAAAGCAGCAGC
ATTTTCTTTTAGATAATTGGCATTAAAATCATTGACATTTTTTGCCATGTCATTATTTAGTAAATTATTT
TCAGCTGCTTTTGAGTTGATGCTATTTTGAACACTTGCATTAATATTTGATGTGATGGCATTGATACCTG
AGCCTATTTCACTTCTTAAACTTCCAAGTTGATCCATAAAATTTGTAATACTATCTTGACTATCTATGCT
TAATCCATCTGTTGCTAATGGATTTAAATTTGTAGTTTCAGTTCCGCTACCTACTACAAAATTCATAGTT
TGAAAGACATTTTTTCCATTATAAGTTGCATTATTAAAAGAATCATTGATGGATTCTTGTATGCGTGTTG
CTTCTGTTCTTAGCATTCCTTTTTGAGAATCATTAAGTGCAGCATTGTTCATTTTTACTGAAAGTTCATT
AAGTCTATCTGCGCTTTGAGAGATATTGGTAAGGCTAGCATCTGCAATTTGTAAAACCCCTATAGCATCA
TAAGCATTTGCGACACCTTGATCTATAGTGCTTGATTGAGATCTTAAAGAATCAGCAATAGCTAAATTAG
CACTATCAACTCCACTTATTGCGCGAACAGCTGCAATATTTTCTAAAGCTTTATCGCTAGCTTTTTGTGC
ATTATTTAAATAATAATTTTGTTGCATCATAGTTGCATCAGAGATCATCA
Protein Sequence 
>gi|218562359|ref|YP_002344138.1| flagellin [Campylobacter jejuni subsp. jejuni NCTC 11168]
MMISDATMMQQNYYLNNAQKASDKALENIAAVRAISGVDSANLAIADSLRSQSSTIDQGVANAYDAIGVL
QIADASLTNISQSADRLNELSVKMNNAALNDSQKGMLRTEATRIQESINDSFNNATYNGKNVFQTMNFVV
GSGTETTNLNPLATDGLSIDSQDSITNFMDQLGSLRSEIGSGINAITSNINASVQNSINSKAAENNLLNN
DMAKNVNDFNANYLKENAAAFVAAQSNMQLQSKIANLLQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Invasion of HEp-2 cells by flaC null mutants was reduced to a level of 14% compared with wild type (Song et al., 2004)
References
Song et al., 2004: Song YC, Jin S, Louie H, Ng D, Lau R, Zhang Y, Weerasekera R, Al Rashid S, Ward LA, Der SD, Chan VL. FlaC, a protein of Campylobacter jejuni TGH9011 (ATCC43431) secreted through the flagellar apparatus, binds epithelial cells and influences cell invasion. Molecular microbiology. 2004; 53(2); 541-553. [PubMed: 15228533].