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sdaA

Victor ID 844
Gene Name sdaA
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905896
NCBI Protein GI 218563213
Locus Tag Cj1624c
Genbank Accession AL111168
Protein Accession YP_002344993
Other Database IDs UniProtKB-ID: Q0P804_CAMJE
UniRef100: UniRef100_A3YJW6
UniRef90: UniRef90_A1W1M6
UniRef50: UniRef50_Q9ZMU7
UniParc: UPI00000C1F9F
EMBL: AL111168
EMBL-CDS: CAL35721.1
RefSeq_NT: NC_002163.1
GenomeReviews: AL111168_GR
KEGG: cje:Cj1624c
HOGENOM: HBG304565
OMA: WKAQEEL
ProtClustDB: CLSK872274
BioCyc: CJEJ192222:CJ1624C-MONOMER
Taxonomy ID 192222
Gene Starting Position 1551754
Gene Ending Position 1553118
Gene Strand (Orientation) -
Protein Name L-serine dehydratase
Protein pI 6.26
Protein Weight 47223.46
Protein Length 454
Protein Note Original (2000) note: Cj1624c, sdaA, probable L-serine dehydratase, len: 454 aa; similar to many e.g. SDHL_ECOLI L-serine dehydratase 1 (EC 4.2.1.13) (454 aa),fasta scores; opt: 1316 z-score: 1553.3 E(): 0, 46.0% identity in 465 aa overlap. 53.4% identity to HP0132~Updated (2006) note: Pfam domains PF03313 Serine dehydratase alpha chain and PF03315 Serine dehydratase beta chain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification -Degradation - Amino acids~PMID:8436113, PMID:14688104
DNA Sequence 
>gi|15791399:1551754-1553118 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
TTTAGCATACTGTTTTTAAATTTGTAGCAAGACCACCTAAAGAAGTTTCTTTATATTTATAATTCATATC
TTTTCCTGTTTCATACATGGTTTCTATAACCTCATCAAGGCTTACCATAGGAGTGGATTTGCGTGTCATT
GCCATTCTAGCAGCACTTATGGCCTTAATGGCTCCAAAGGCATTTCTTTCTATGCAAGGAATTTGCACAA
GTCCTGCAACTGGATCGCAAGTTAGACCTAGATGATGTTCCATTGCCATTTCAGCAGCATTACATGCTTT
AAAAGCATTAGCTCCTAAAACTGTTGCCATAGCCGCAGCTGCCATAGAACTAGCACTACCAATTTCTGCT
TGACAACCTGCTTCTGCTCCGCTAATACTTGCATTTTTCTTATAAAAAGAACCTATAAGCATTGCTGTTA
ATAAAAACTCTATAACCTTTTCATCACTAAAACCTATAGTATGATTTTTAAGATAAAGCATAACAGCAGG
GATAACAGCACATGCTCCATTTGTTGGTGCGGTTACGACTTTTGCTCCGCTAGCATTTTCTTCAGCAATC
GCAATAGCATATAAAGAAATAAAATCGATAATACCCATAGGATCAGCTGTCATCGCTACTCTTTCTTTAA
GTCCTTTAGCTCTACGCTTTAAATGAAGTTTTCCAGGCAAATAATCTTCATTCGGGTGCGTACCATTATA
ATACACTTCTTGCATCACTTCCCAAATTTCAAGACAATAAGCACAAATTTCCTCTTTAGTGTGAAATTGC
AATTCATAACGATAAGAAAGCTCTGCCAAATCCCAATCTCTTTTATCGCAAAGCTCTAAAGCTTCTTTAG
CGTTATTAAGCTCTATATCTAGTTTTTTCTTTTTATTTTGGTTAGAATTTTTACCTTTTTTTTCTAATTC
CGCAGCTGTTAAAACAAAGCCTCCACCTACAGAATAATAAGTTTCCTCATCAACTAACCCACCTTTACAA
TCATAAGCTTTAATTTTCATACCATTCTCATGTAAAGGTAAAAAATCTTTAGAAAATATCAAATCTTTTT
CATAATTAAAACTAAGTTTTTTCTCGCCACAAAAATCAATTTGAGCATTTTCAATAGCATTTTTATTTAC
TTCATCTTGTATTGCCGCACTTAAATTTTTAGCTTCTAAGCCATTTAACCCCCAAATCACAGCCTTATCA
CTCAAGTGTCCTTTGCCTGTTAACGACAAAGAACCATAAAGAGTAACCTCAACTCTATCAATTTCATCAA
GCTTTTTAGCAACTTTTTTACAAAATAAATTTCCAGCAAGCATAGGCCCTAAAGTATGAGAAGAAGAAGG
GCCAACACCTATTTTAAAAATGCTTAAATTACTCA
Protein Sequence 
>gi|218563213|ref|YP_002344993.1| L-serine dehydratase [Campylobacter jejuni subsp. jejuni NCTC 11168]
MSNLSIFKIGVGPSSSHTLGPMLAGNLFCKKVAKKLDEIDRVEVTLYGSLSLTGKGHLSDKAVIWGLNGL
EAKNLSAAIQDEVNKNAIENAQIDFCGEKKLSFNYEKDLIFSKDFLPLHENGMKIKAYDCKGGLVDEETY
YSVGGGFVLTAAELEKKGKNSNQNKKKKLDIELNNAKEALELCDKRDWDLAELSYRYELQFHTKEEICAY
CLEIWEVMQEVYYNGTHPNEDYLPGKLHLKRRAKGLKERVAMTADPMGIIDFISLYAIAIAEENASGAKV
VTAPTNGACAVIPAVMLYLKNHTIGFSDEKVIEFLLTAMLIGSFYKKNASISGAEAGCQAEIGSASSMAA
AAMATVLGANAFKACNAAEMAMEHHLGLTCDPVAGLVQIPCIERNAFGAIKAISAARMAMTRKSTPMVSL
DEVIETMYETGKDMNYKYKETSLGGLATNLKTVC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sdaA mutants completely failed to colonize 3-week-old chickens as assayed both by cloacal swabs taken over a 6-week period and by cecal colony counts postmortem (Velayudhan et al., 2004)
References
Velayudhan et al., 2004: Velayudhan J, Jones MA, Barrow PA, Kelly DJ. L-serine catabolism via an oxygen-labile L-serine dehydratase is essential for colonization of the avian gut by Campylobacter jejuni. Infection and immunity. 2004; 72(1); 260-268. [PubMed: 14688104].