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Cj1461

Victor ID 841
Gene Name Cj1461
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905749
NCBI Protein GI 218563064
Locus Tag Cj1461
Genbank Accession AL111168
Protein Accession YP_002344843
Other Database IDs UniProtKB-ID: Q0P8F4_CAMJE
UniRef100: UniRef100_A3ZGJ6
UniRef90: UniRef90_Q5HSW9
UniRef50: UniRef50_Q5HSW9
UniParc: UPI00000C1F2B
EMBL: AL111168
EMBL-CDS: CAL35569.1
RefSeq_NT: NC_002163.1
REBASE: 16981
GenomeReviews: AL111168_GR
KEGG: cje:Cj1461
HOGENOM: HBG706795
OMA: GSASMGL
ProtClustDB: CLSK879269
Taxonomy ID 192222
Gene Starting Position 1397725
Gene Ending Position 1398408
Gene Strand (Orientation) +
Protein Name putative DNA methylase
Protein pI 9.78
Protein Weight 25705.94
Protein Length 227
Protein Note Original (2000) note: Cj1461, possible DNA methylase, len: 227 aa; similar to hypothetical proteins e.g. YHHF_ECOLI (198 aa), fasta scores; opt: 186 z-score: 224.4 E(): 3.5e-05, 27.1% identity in 181 aa overlap. 37.2% identity to HP0810. Contains PS00092 N-6 Adenine-specific DNA methylases signature~Updated (2006) note: Pfam domain PF03602 Conserved hypothetical protein identified within CDS. Specific characterisation with acceptable identity score has not been carried out yet, so putative kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair
DNA Sequence 
>gi|15791399:1397725-1398408 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
GATGAATGATGAATTTATAAGCGTTAAAGACTTTTTTAATCACAATGAAAAAAGAAAAAAATTTCTTCAA
AAACAAGAAATTAAACCTCCTAAAGAAAAAACAAAAAAAACTAAAGAAACAAAGCTTTATACAAATATAG
AAAGTGGTAAATACAAAGGGAAAAAACTACTTTTACCTAGTCTTACAACAACAAGAAGTACTAAAAGCAT
AGTCAAAAGTTGTGTTTTTAATGTAATAAGAGAAGATTTAAGAAGTAAAATTTTCATTGAAGCCTTTGGC
GGAAGTGCTTTAATAGCGGCTGAAGCACTAAGTAATTATGCTTTAAAAGCTTATGCTATAGAACTTGATA
TAAAAGCTTATAAAATTGCTTTAGAAAATGCTAAAAACATAGATCCAAATTTAGAAGTGATCCATGCAAA
TACTTTTGAAATTTTACCTAAACTCATAGAAAATTCAAAAAATGAAATCATCTTATATCTTGACCCACCT
TTTGATATCAGAGAAGGTTTTAGTGATATTTATGAAAAAATTTATCATTTTTTAGAAAATTTAGATTTAA
AGACTTTAAATTTAATCATTTTTGAATACCACTCAACCATAAAAACTCCCGAAAAAATCCAAAATTTTCA
AAAAGTTAAAGAAAAGAAATTTGGATCAACTAGCTTAAGTTTTTACTCTTCTTA
Protein Sequence 
>gi|218563064|ref|YP_002344843.1| putative DNA methylase [Campylobacter jejuni subsp. jejuni NCTC 11168]
MNDEFISVKDFFNHNEKRKKFLQKQEIKPPKEKTKKTKETKLYTNIESGKYKGKKLLLPSLTTTRSTKSI
VKSCVFNVIREDLRSKIFIEAFGGSALIAAEALSNYALKAYAIELDIKAYKIALENAKNIDPNLEVIHAN
TFEILPKLIENSKNEIILYLDPPFDIREGFSDIYEKIYHFLENLDLKTLNLIIFEYHSTIKTPEKIQNFQ
KVKEKKFGSTSLSFYSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A Deltacj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type (Kim et al., 2008)
References
Kim et al., 2008: Kim JS, Li J, Barnes IH, Baltzegar DA, Pajaniappan M, Cullen TW, Trent MS, Burns CM, Thompson SA. Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics. Journal of bacteriology. 2008; 190(19); 6524-6529. [PubMed: 18689478].