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Cj0415 |
| Victor ID |
808 |
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Gene Name |
Cj0415 |
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Sequence Strain (Species/Organism) |
Campylobacter jejuni subsp. jejuni NCTC 11168 |
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NCBI Gene ID |
904739
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NCBI Protein GI |
218562073
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Locus Tag |
Cj0415 |
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Genbank Accession |
AL111168 |
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Protein Accession |
YP_002343852 |
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Other Database IDs |
UniProtKB-ID: Q0PB95_CAMJE
UniRef100: UniRef100_A3YJ47
UniRef90: UniRef90_A1VYD5
UniRef50: UniRef50_A8FKK2
UniParc: UPI00000C2114
EMBL: AL111168
EMBL-CDS: CAL34565.1
RefSeq_NT: NC_002163.1
GenomeReviews: AL111168_GR
KEGG: cje:Cj0415
HOGENOM: HBG691754
OMA: YCERFGC
ProtClustDB: CLSK867131
BioCyc: CJEJ192222:CJ0415-MONOMER
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Taxonomy ID |
192222
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Gene Starting Position |
381666 |
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Gene Ending Position |
383387 |
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Gene Strand (Orientation) |
+ |
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Protein Name |
putative GMC oxidoreductase subunit |
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Protein pI |
8.8 |
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Protein Weight |
60608.64 |
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Protein Length |
573 |
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Protein Note |
Original (2000) note: Cj0415, possible oxidoreductase subunit, len: 573 aa; similar to e.g. TR:O34214 (EMBL: U97665) Erwinia cypripedii gluconate dehydrogenase subunit precursor (615 aa), fasta scores; opt: 1025 z-score: 1674.4 E(): 0, 40.8% identity in 583 aa overlap. No Hp match~Updated (2006) note: Pfam domain PF00732 GMC (glucose-methanol-choline) oxidoreductase was identified within CDS when carrying out own Pfam search. This family is a member of the FAD/NAD(P)-binding Rossmann fold Superfamily clan. These proteins bind FAD as a cofactor. Product modified to more specific family member due to motif match. Literature search identified paper giving further related functional clues. No specific characterisaion with acceptable identity score has been carried out yet, so putative kept within product function. Literature search identified paper linking protein to glycoprotein (Young et al., 2002). Functional classification -Misc~PMID:15231804, PMID:12186869 |
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DNA Sequence |
>gi|15791399:381666-383387 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
AATGGCTGAAGTATTAAAAAAAGTAGATGTAGTAACAGTTGGAGCAGGATGGACTGGAGGTATAGTGGCT
GCAGAGCTTACTAAAGCAGGTTTGAATGTACTTAGTTTAGAACGCGGACATATGCAAAGTACTGAAAATT
TTAATTATATCCATGATGAGTGGAGATATGGGATTAATTATGGTTTGATGCAAGATTGCTCAAAAGACAC
TGTGACTTTTCGCCATGATCCTAGTGGTTTAGCCTTACCTTATCGTAAAATGGGTTCGTTTTTATTGGGT
AATAATGTTGGCGGTGCAGGGGTGCATTGGAATGGTTGGACTTTTAGGTTTATGCCTTATGACTTTGAAA
TTCAAACCCTAAGCAAACAAAGATATGGTAATAAATTAGGTAATGATTATACCTTGCAAGATTGGGGCGT
GACTTATAAGGATATGGAGCCTTATTATGATAGATTTGAAAAAACCTGTGGGGTATCAGGTGAACCAAAT
CCTTTAGCGGAAAAAATGGGAGCTTTTAGATCCAGTCCTTATCCACAAGAACCTCTTGAAAATACTAAAA
TGCTTAAACGATTTGAAAGTGCAGCAAAAAGTTCAAATTTACACACTTATCGTTTGCCAGCTTCAAATTC
TAAAGGTGGCTATACAAACCCTGATGGTCAAGATTTAGCTCCTTGTCAATACTGTGCGTATTGTGAGCGT
TTTGGTTGTGAGTATGGTGCAAAAGCAAGTCCTTTAAACACAGTAATTCCAAAGGCTATGAGCACAGGTA
AATACACCATACGCACTTATAGTAATGTAACGCAAATTCTTAAAAAAGACGGAAAAGTAACGGGGGTAAA
ATTTGTCGATACTAGAACGATGAAAGAGTATATCCAGCCTGCTGATATAGTTGTACTTACAAGTTATATG
TTTAACAATGCTAAGCTTTTAATGGTAAGCAACATAGGTGAGCAATACGATCCAAAAACAGGTAAAGGAA
CTTTAGGTAGAAATTATTGTTACCAAATGAACATGGGCACAACAGCTTTCTTTGATGAGCAATTTAACAC
CTTTATGGGTTCAGGTGCTTTAGGAACTACGAGTGATGATTTTAACGGAGATAATTTTGATCATTCTAAG
GAAAAATTCCTTCATGGAGCTATGATTTATAGCGTTCAGCTTGGAACTCGCCCTATACAATCAGCCCCAC
TTCCAGCAGGAGCTCCAACTTGGGGTGCCGAATTTAAAAAAGCATTAAACTATAATTTCACAAGAGCTAT
TACCGTAGGAGGGCAAGGTGCTTCTTTGCCTCATAAGAATAATTATTTAAGTCTTGATCCAACTTATAAA
GATGCTTTTGGTATGCCACTTTTACGCTTAACTTATAATTTCACTGATCAAGATAGAGCTTTGCATAAAT
TTATCACAGATAAAACAGCTGAGGTAGCAAAAAGAATGCAAGGAGTAAAATCAATCAAAAAAGGTGCTTA
TCTTAAGGATTATAGCGTTGTGCCTTATCAATCTACTCATAACACAGGTGGAACAACCATGGGCGCAGAT
AGAGAAACTAGTGTGGTTAATACTTATTTACAACACTGGGATGCGGATAATCTTTTTGTTGTAGGAGCAG
GAAATTTCCAACATAATAGTGGATATAATCCAACTGATACTGTGGGAGCTTTGGCTTATCGCTGTGCTGA
AGGTATTTTAAAATATCATAAAAGTGGAAAAAGCTTAGCTTG
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Protein Sequence |
>gi|218562073|ref|YP_002343852.1| putative GMC oxidoreductase subunit [Campylobacter jejuni subsp. jejuni NCTC 11168]
MAEVLKKVDVVTVGAGWTGGIVAAELTKAGLNVLSLERGHMQSTENFNYIHDEWRYGINYGLMQDCSKDT
VTFRHDPSGLALPYRKMGSFLLGNNVGGAGVHWNGWTFRFMPYDFEIQTLSKQRYGNKLGNDYTLQDWGV
TYKDMEPYYDRFEKTCGVSGEPNPLAEKMGAFRSSPYPQEPLENTKMLKRFESAAKSSNLHTYRLPASNS
KGGYTNPDGQDLAPCQYCAYCERFGCEYGAKASPLNTVIPKAMSTGKYTIRTYSNVTQILKKDGKVTGVK
FVDTRTMKEYIQPADIVVLTSYMFNNAKLLMVSNIGEQYDPKTGKGTLGRNYCYQMNMGTTAFFDEQFNT
FMGSGALGTTSDDFNGDNFDHSKEKFLHGAMIYSVQLGTRPIQSAPLPAGAPTWGAEFKKALNYNFTRAI
TVGGQGASLPHKNNYLSLDPTYKDAFGMPLLRLTYNFTDQDRALHKFITDKTAEVAKRMQGVKSIKKGAY
LKDYSVVPYQSTHNTGGTTMGADRETSVVNTYLQHWDADNLFVVGAGNFQHNSGYNPTDTVGALAYRCAE
GILKYHKSGKSLA
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Molecule Role |
Virulence factor |
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Molecule Role Annotation |
MUTATION: a cj0415 mutant was impaired in establishing chicken colonization (Pajaniappan et al., 2008) |
| References |
Pajaniappan et al., 2008: Pajaniappan M, Hall JE, Cawthraw SA, Newell DG, Gaynor EC, Fields JA, Rathbun KM, Agee WA, Burns CM, Hall SJ, Kelly DJ, Thompson SA. A temperature-regulated Campylobacter jejuni gluconate dehydrogenase is involved in respiration-dependent energy conservation and chicken colonization. Molecular microbiology. 2008; 68(2); 474-491. [PubMed: 18284594].
Young et al., 2002: Young NM, Brisson JR, Kelly J, Watson DC, Tessier L, Lanthier PH, Jarrell HC, Cadotte N, St Michael F, Aberg E, Szymanski CM. Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni. The Journal of biological chemistry. 2002; 277(45); 42530-42539. [PubMed: 12186869].
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