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Cj1325

Victor ID 835
Gene Name Cj1325
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni NCTC 11168
NCBI Gene ID 905617
NCBI Protein GI 218562936
Locus Tag Cj1325
Genbank Accession AL111168
Protein Accession YP_002344715
Other Database IDs UniProtKB-ID: Q0P8T2_CAMJE
UniRef100: UniRef100_E0QBH7
UniRef90: UniRef90_E0QBH7
UniRef50: UniRef50_Q7X524
UniParc: UPI0000DBEB22
EMBL: AL111168
EMBL-CDS: CAL35439.1
RefSeq_NT: NC_002163.1
GenomeReviews: AL111168_GR
KEGG: cje:Cj1325
HOGENOM: HBG391627
ProtClustDB: CLSK878669
BioCyc: CJEJ192222:CJ1325-MONOMER
Taxonomy ID 192222
Gene Starting Position 1253416
Gene Ending Position 1254091
Gene Strand (Orientation) +
Protein Name putative methyltransferase
Protein pI 5.95
Protein Weight 25432.08
Protein Length 224
Protein Note Original (2000) note: Cj1326, unknown, len: 140 aa; no Hp match. Contains polyporphic sequence G(9-10) at N-terminus; G(9) allows translation from the upstream CDS Cj1325, G(10) (consensus) would only allow this CDS to start at aa 22. Similar to Cj0171 (51.9% identity in 135 aa overlap), which also contains a polymorphic sequence allowing possible translation from Cj0170~Original (2000) note: Cj1325, unknown, len: 89 aa; no Hp match. Contains polyporphic sequence G(9-10) at C-terminus; G(10) (consensus) gives this translation stop,G(9) allows translation into the downstream CDS Cj1326. Similar to Cj0170 (73.8% identity in 61 aa overlap), which also contains a polymorphic sequence allowing possible translation into Cj0171~Updated (2006) note: Pfam domains PF08241 and PPF08242 both Methyltransferase domains were identified within CDS. Product function modified to more specific family member. No specific characterisation has been carried out yet. Putative kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (Champion et al., 2005). Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj1325 and Cj1326 as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Misc~PMID:16230626, PMID:14985343
DNA Sequence 
>gi|15791399:1253416-1254091 Campylobacter jejuni subsp. jejuni NCTC 11168 chromosome, complete genome
AATGCAAAACTCATTAGAAGCTTATACAATGAAATATAATGAAAATGGATACGGATTACTTTTTCCAGAT
GGTCATGTAGTACGTTTTTATGAAAGAATTTTAAAATACAAACTAAATAAAATAAATGGAAATTTACTTG
ATTTTGGTTGTGGCAATGGTGTACATTCAGCGTATTTTCAAAGCAAAGGGTTTAAAACTTTTGGAATAGA
TATAGTTCCAAGTTTAAAAGAAATTTGGGAGCAAAATATTAGCGGGGGGGGGGTATTGTAAAATTATAGA
ACCAAATTCTAGCATCAAAGGACTTTTTGATGAAAATATGGATATTATCTTTGCAAATCAAAGTCTTTAC
TACATACCTCTAAAAGAACTTAAACAAAATATTTTAGAATTTTACGAACTTTTGAACACAGGTGGAATAC
TTTTTGCTACAATGATGAGCAAGAAAAATTATTATTTTTCCCACAGTCAAAAAGAAGAAAAAAATGGCTT
GAGTAAAGTTGAAATTAATGGAAGATTAAATGAAACAAGCTTTATACATTTCATCGATAAAGCCGAAGAT
CTAGAAAATCTTTTTCAACCTTTTGAAACTTTATTTCTAGGAGATTATGATCCTATTAATTTTTATAATT
TTGAAGGATCGGCACACCATTATATTTATATAGGTATTAAAAAATA
Protein Sequence 
>gi|218562936|ref|YP_002344715.1| putative methyltransferase [Campylobacter jejuni subsp. jejuni NCTC 11168]
MQNSLEAYTMKYNENGYGLLFPDGHVVRFYERILKYKLNKINGNLLDFGCGNGVHSAYFQSKGFKTFGID
IVPSLKEIWEQNISGGGYCKIIEPNSSIKGLFDENMDIIFANQSLYYIPLKELKQNILEFYELLNTGGIL
FATMMSKKNYYFSHSQKEEKNGLSKVEINGRLNETSFIHFIDKAEDLENLFQPFETLFLGDYDPINFYNF
EGSAHHYIYIGIKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: colonization of chick ceca by a Ãâ(Cj1321-Cj1325/6) mutant was reduced (<a href="#reference11121">Howard et al., 2009</a>)
References
Champion et al., 2005: Champion OL, Gaunt MW, Gundogdu O, Elmi A, Witney AA, Hinds J, Dorrell N, Wren BW. Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(44); 16043-16048. [PubMed: 16230626].