| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
M2AP |
Toxoplasma gondii ME49 |
7900755
|
|
237843035
|
TGME49_014940 |
DS984747 |
XP_002370815 |
|
Virulence factor |
MUTATION: M2AP mutant is attenuated for cell invasion and virulence in mice [Ref7011:Huynh et al., 2006].
|
16385407
|
|
|
MyoA |
Toxoplasma gondii |
|
|
50400802
|
|
|
|
Myosin-A |
Virulence factor |
MUTATION: myoA mutant has severe impairment in host cell invasion and parasite spreading in cultured cells [Ref7012:Meissner et al., 2002].
|
12399593
|
|
|
MIC8 |
Toxoplasma gondii |
|
13346486
|
13346487
|
|
|
AAK19757.1 |
microneme protein 8 |
Virulence factor |
MUTATION: MIC8 mutant is deficient for invasion in HFF, HeLa, and other cell types [Ref7013:Kessler et al., 2008].
|
18319299
|
|
|
ROP18 |
Toxoplasma gondii ME49 |
7894256
|
|
237840093
|
TGME49_052360 |
DS984739 |
XP_002369344 |
|
Virulence factor |
MUTATION: Transfection of the virulent ROP18 allele into a nonpathogenic type III strain increased growth and enhanced mortality by 4 to 5 logs [Ref7014:Taylor et al., 2006].
|
17170305
|
|
|
ROP2 |
Toxoplasma gondii |
|
|
563627
|
|
|
|
ROP 2 |
Virulence factor |
MUTATION: Targeted depletion of ROP2 using a ribozyme-modified antisense RNA strategy resulted in multiple effects on parasite morphology because of a disruption in the formation of mature rhoptries, and an arrest in cytokinesis. The association of host cell mitochondria with the parasitophorous vacuole membrane was abolished and the ROP2-deficient parasites had a reduced uptake of sterol from the host cell. Furthermore, these parasites invaded human fibroblasts poorly and had markedly attenuated virulence in mice [Ref7015:Nakaar et al., 2003]. |
12711703
|
|
|
SAG1 |
Toxoplasma gondii ME49 |
7900172
|
|
237839159
|
TGME49_034370 |
DS984737 |
XP_002368877 |
|
Virulence factor |
MUTATION: a SAG1 mutant is attenuated in mice in an oral model of infection [Ref7016:Rachinel et al., 2004].
|
15294991
|
|
|
MIC2 |
Toxoplasma gondii |
|
|
1923217
|
|
|
|
micronemal protein MIC2 |
Virulence factor |
MUTATION:A mic2 mutant is attenuated in mice [Ref7331:Huynh and Carruthers, 2006]. |
16933991
|
|
|
OMPDC |
Toxoplasma gondii ME49 |
7899615
|
|
237831731
|
TGME49_059690 |
DS984728 |
XP_002365163 |
|
Virulence factor |
MUTATION: An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice [Ref7356:Fox and Bzik, 2010]. |
20605980
|
|
|
UP |
Toxoplasma gondii ME49 |
7900273
|
|
237830025
|
TGME49_110640 |
DS984727 |
XP_002364310 |
|
Virulence factor |
MUTATION: A UP mutant, in combination with an OMPDC mutation, is attenuated in mice [Ref7356:Fox and Bzik, 2010]. |
20605980
|
|
|
hsp70 |
|
|
|
12248795
|
|
|
|
|
Virulence factor |
Virulent parasites with reduced HSP70 expression displayed reduced proliferation in vivo, as measured by the number of tachyzoites present in spleens of infected mice.
[Ref7558:Dobbin et al., 2002] |
12097402
|
|
|
SAG3 |
|
|
|
323650767
|
|
|
|
surface antigen 3 |
Virulence factor |
the null SAG3 mutants show attenuated infectivity, with a markedly reduced capacity to cause mortality in mice, whereas both wild-type and complemented mutants that re-expressed SAG3 were lethal at the same doses. [Ref7557:Dzierszinski et al., 2000]
|
10931351
|
|
|
MIC1 |
Toxoplasma gondii ME49 |
7896467
|
|
237838467
|
TGME49_091890 |
DS984735 |
XP_002368531 |
|
Virulence factor |
Individual disruption of MIC1 or MIC3 genes slightly reduced virulence in the mouse, whereas doubly depleted parasites were severely impaired in virulence and conferred protection against subsequent challenge. [Ref7559:Cérède et al., 2005]
|
15684324
|
|
|
MIC3 |
Toxoplasma gondii ME49 |
7901253
|
|
237841071
|
TGME49_119560 |
DS984741 |
XP_002369833 |
|
Virulence factor |
Individual disruption of MIC1 or MIC3 genes slightly reduced virulence in the mouse, whereas doubly depleted parasites were severely impaired in virulence and conferred protection against subsequent challenge. [Ref7559:Cérède et al., 2005]
|
15684324
|
|
|
NF3 |
|
|
|
672577341
|
|
|
|
nuclear factor NF3 |
Virulence factor |
TgNF3 has a direct role in transcriptional control of genes involved in parasite metabolism, transcription and translation. The ectopic expression of TgNF3 in the tachyzoites revealed dynamic changes in the size of the nucleolus, leading to a severe attenuation of virulence in vivo. [Ref7560:Olguin-Lamas et al., 2011]
|
21483487
|
|
|
GRA3 |
Toxoplasma gondii ME49 |
7895127
|
|
237834147
|
TGME49_027280 |
DS984730 |
XP_002366371 |
|
Virulence factor |
Dense granule protein3 (GRA3), which was found to have a higher expression in low virulent TgCtwh6 (Wh6) strain than that in high virulent TgCtwh3 (Wh3) strain.
[Ref7561:Li et al., 2014] |
24678633
|
|
|
GRA25 |
|
|
|
527311405
|
|
|
|
hypothetical protein |
Virulence factor |
In vitro experiments with a type II Δgra25 strain showed that macrophages infected with this strain secrete lower levels of CCL2 and CXCL1 than those infected with the wild-type or complemented control parasites. In vivo experiments showed that mice infected with a type II Δgra25 strain are able to survive an otherwise lethal dose of Toxoplasma tachyzoites and that complementation of the mutant with an ectopic copy of GRA25 largely rescues this phenotype.[Ref7563:Shastri et al., 2014]
|
24711568
|
|
|
TGME49_050770 |
Toxoplasma gondii ME49 |
7901351
|
|
237836123
|
TGME49_050770 |
DS984732 |
XP_002367359 |
|
Virulence factor |
The T. gondii eukaryotic translation initiation factor 4A (eIF4A) protein is expressed in the tachyzoite, but its expression is markedly downregulated in the bradyzoite, and it is therefore considered to be associated with tachyzoite virulence.[Ref7564:Chen et al., 2014]
|
24841780
|
|
|
Rop5 |
|
|
|
134035971
|
|
|
|
rhoptry protein 5 |
Virulence factor |
it is striking that deletion of the ROP5 cluster in a highly virulent strain caused a complete loss of virulence, showing that ROP5 proteins are, in fact, indispensable for Toxoplasma to cause disease in mice.[Ref7596:Reese et al., 2011]
|
21436047
|
|
|
eIF4A |
Toxoplasma gondii ME49 |
7901351
|
|
237836123
|
TGME49_050770 |
DS984732 |
XP_002367359 |
|
Virulence factor |
Eukaryotic translation initiation factor (eIF4A) is a newly identified protein associated with tachyzoite virulence.
[Ref7597:Chen et al., 2013] |
23370151
|
|
|
GRA7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
ROP5 |
Toxoplasma gondii strain GT1 |
|
|
334848096
|
|
BK008051 |
|
type I rhoptry protein 5 |
Virulence factor |
a family of serine/threonine protein kinases found in rhoptries (ROPs) play an important role in mediating Toxoplasma gondii virulence. Deletion of ROP5 greatly reduces virulence. [Ref7605:Behnke et al., 2011] |
21586633
|
|
|
MIC5 |
|
|
|
527308770
|
|
|
|
microneme protein MIC5 |
Virulence factor |
genetic ablation of the micronemal protein MIC5 enhances the normal proteolytic processing of several micronemal proteins secreted by Toxoplasma tachyzoites.
[Ref7607:Brydges et al., 2006] |
16980407
|
|
|
GRA6 |
|
|
|
37538307
|
|
|
|
Dense granule protein 6 |
Virulence factor |
the dense granule proteins GRA4 and GRA6 in cyst development since brain tissue cyst burdens were drastically reduced specifically in mutant strains with GRA4 and/or GRA6 deleted. Complementation of the Δgra4 and Δgra6 mutant strains using a functional allele of the deleted GRA coding region placed under the control of the endogenous UPRT locus was found to significantly restore brain cyst burdens.[Ref7608:Fox et al., 2011]
|
21531875
|
|
|
GRA4 |
|
|
|
527309516
|
|
|
|
dense granule protein GRA4 |
Virulence factor |
the dense granule proteins GRA4 and GRA6 in cyst development since brain tissue cyst burdens were drastically reduced specifically in mutant strains with GRA4 and/or GRA6 deleted. Complementation of the Δgra4 and Δgra6 mutant strains using a functional allele of the deleted GRA coding region placed under the control of the endogenous UPRT locus was found to significantly restore brain cyst burdens.[Ref7608:Fox et al., 2011]
|
21531875
|
|
|
GRA2 |
|
|
|
2506908
|
|
|
|
Dense granule protein 2 |
Virulence factor |
The survival rate of mice inoculated with Deltagra2 was significantly higher; some infected mice survived the acute infection, whereas all mice infected with the wild-type strain RH succumbed to early death. absence of GRA2 partially attenuates the virulence of T. gondii during the acute phase of infection and allows for establishment of chronic infection by the otherwise highly virulent RH strain.[Ref7609:Mercier et al., 1998]
|
9712765
|
|
|
rop16 |
|
|
|
296280509
|
|
|
|
rhoptry protein 16 |
Virulence factor |
Here we use genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16. Upon invasion by the parasite, this polymorphic protein is released from the apical organelles known as rhoptries and injected into the host cell, where it ultimately affects the activation of signal transducer and activator of transcription (STAT) signalling pathways and consequent downstream effects on a key host cytokine, interleukin (IL)-12.[Ref7612:Saeij et al., 2007]
|
17183270
|
