Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

UP

Victor ID 4936
Gene Name UP
Sequence Strain (Species/Organism) Toxoplasma gondii ME49
NCBI Gene ID 7900273
NCBI Protein GI 237830025
Locus Tag TGME49_110640
Genbank Accession DS984727
Protein Accession XP_002364310
Taxonomy ID 508771
Gene Starting Position 1252500
Gene Ending Position 1256433
Gene Strand (Orientation) -
Protein pI 7.12
Protein Weight 31157.07
Protein Length 303
DNA Sequence 
>gi|212659389:1252500-1256433 Toxoplasma gondii ME49 scf_1112359874864, whole genome shotgun sequence
GCGTCCCCCGCATTTCGGCAATCCGCGTTTGAACGAAACAATTGCTTGAGCAGCACGGAACTGCGTTGGC
TCTAAAGGCCGCCTGGTTGTACATATACTTTGTGAAAGCCTTCCTTTCCGCCGACCGTCCACTCGAGGCA
AAAACATGGGGGCGGAGAAAACCTGGAGAGGCACGGAAACGTGTGTACGTCGCCCCACTCATCTCCAGAA
TCTCTATCCCACATCTGAAACCCGCTGACGGTGCCTTTGTTGCGTTTTTGTAGGCCGGCCGCAGACGTCA
GTTTCCAGTGCGGCACGTGGACTGCGAAGCGCTCGGCGGTCCAGTGAACATTTCCAAGCAGACAGCCTCT
GTGTGGACTGCTCTGGACCGGGAGGAGAAATTTACGCTCTCTGTGCACGTAACTAATGACGAAGAACCCC
TAAAACGCTCACACGCAGTCTCGCGGTGCTTTTTTCGGGAGCAGCTCTCCTGCGTGGGAATGAAACCCAT
CATTTGAATTCATGACACGAGGGCCCAAGGCAAATATGGAACCCCAGAACCACCGTTCCGTTCTCTCTGG
TAACGTGGTACTGTGTGCATCATCTGGTTACAGTCCTAGAGTGCGCAGCGAGGACGACGTCTGCGCGAGG
GCGCTGGATTTGCTCCGTTCGTCTTTGTGCGCCGCGTATCCACAGTACTTTCATCACCGGCCTTGATGCC
TCCGAAGTTGCTGCTCATGACCTGCTCAGTTGCTTTACGCCGCAGGCTTGATGATGCCTTCGGAAACAAG
TGTCACAAGGGCATCAAAGGCAGCTTCGCCCGCTGCCAAAGTAGCCTTATCTTGGTCTTCCGCCTAAACG
CGACACACACACACAAAAAAAAAACAAGAAAAGTACAGAGTGACACAGCGTGGAAAGTCACTCCATCACC
TAGTTTGCGCTTCGTTTTCGTTGACACAGGCGTCGGCGCCTGTTTGCGGCGGAGTCTGTTTTGTCGTATC
TCCATGACACAACACTGTCTTTTCTTCTCTACCGAGGCAACCCAGAAGGAGAGTGTGACCTCACTCCTTG
ACATTTCTCCCCTCCTCCTGTTTCCGCTCACCGTCACGTGAGCTGTCAAGTTCGGATTGCTCCGGTTCAC
AAGGCCGATCATGAGAGAGGCGGCGTACGACTTGGGTCCGTTTGGGATGCTGTGCTGTCTCTGGTGCATG
AGATGGAAGATTTGGTGCGTCTCCATCTCCAGACTCACGACCCCCAGGTCTGTCATGTCCTTCAGGAGGT
TCGCGTTATTGTCGTTCCACAGCGGCAACTCTCTGCCCTGAATCGCATGCACACAAGAAACACGGCATGA
CCACACATTCACCTTCTCATCCTCTTACCGGCAATCTTTCGAGGTTCCCTTTACCTACGCGTCAAGCGCA
CTGGTGCGATCACGCGTGCGATAGCGCGAAGGAAAACACGAATCCAGCAAGCCTCGACAAGTGGTGAGGT
ATGTGTACCTGCGCCAGGCATCGCCGATGCAAAAGGGATGAGGAGGACCCTCGGGTCCCTCCTCAATCGG
TGTATGTGAAAAGACACTGTCCCTCCCTTTCGGCTAAGGTTCCACGCCTTCGGTGACTAGACTATATGCG
CTATACACACAAGGTCAACAAGTGTCAAAGTTTGGCCATCAACAGCCAGTGCCAAAAGCACATACCCGCG
TACCGCAGGCGGGGCAGCCGGTAGGCGCTGGTCGTTACCGCCCCCCCCTTGTGTGCCACCTTGGTCCCCC
CTTTCGGAGAGCGCACACGAGTCAGTACAGTCTTCGAAATCACCTTATTTGATTAACGTAACAGCGCAGA
CGCCTACGGTGCACCGCATGTAAACTGTACATTGGATACGTTTCAGCACTTCAGGGTTGCGAGAACCTTA
TAAATGAGAGAAGAGATGTTCGGTCTAGTGTTCCGTTATCCTACATAGATGACGTGGCTTGTAGCACGTT
TTTGTATCGTGTTTGTAGAAACGGATTACTGCTCACCTGACAAGCGAAGAAAGTCTCCGCCGAGCAGTTG
AGGCCTCGTTTGACTGCTGCACCCTGCGCATTCAAGTTGGCTTCGATAAGATCGGTCAAACGCTTGTCTG
CCTTGACCGGCGCTGTCAGCAAGTAGGGTCGCGGGTCGCGCCCGCACTCCCGTTTGTTTCCCAAAGCTGC
TTCGCCGTCAAAGTGACAGTAGTTCCTAGAAACACAAGCCGAAGCAAACCACCCCCTAGGTTTGTAGATC
CGCGAGAGAGTGCGTGGATTCGACAGCGCACGGACACTTCCGGAGATGCGTGTGCACAACCCGCCCCGCA
GCAGAGCACATGAACGACCAAGCCGAACCCGCTGCGGGTGCACAACACAGCAACTACACAATCAGTCAAG
AGTTCCCGGCCAAAATGCCCGATCAACAATCTACGGCCACACATCAGCTGGGGGTACTTCGTCGTCGTAC
GAGCAGTACCGTGGACACAGCCCATGTAGGGCTTTCTGCCTCTTTACAACCGTGAAATGCCCTTGTCAGT
GAACCGGGTCGCAACTACGAGGTGACAAAAAAAACAGAACTGCACGCCTTTACCTCTGCCCTCACCTGTA
GCAGTACATGCTCTCGTCGCTGAGCATGAGAGTACCCGGCCGGGTCGCGTAGTCGACGATTCCACAACTG
CCAATGCGAACGACGGCCAAGGGTTCTCCTTCCAAAACAAAAGAGGCTTCACGAATGAAAAAATCTGCCA
TCGGAGCACCCATGCCAATGCAGACGATCGACATGCGCTGTCCGCCTTTGATGTATTTGCCTGAAAACAA
GCAGAGAAAAACGAATACTAGAGAGTTGTGAACGCCAAAAAACAATCCGAAGAAAGCCACCGCCGACCAG
CAGGAGTTGCCACGAGCTGGAGGTCCTCGGGTTTGTCGAAGCACTATCATGCTATGACACCCCGAAGCAC
ACGACTTAAAAGATCGTTCAAAGCTCCCTCACCCTGTTCGGGTGCTCCCCATACACAAGATCTACGTGGG
GGTGCTCACGCGTCCAGTTCGGTCTATCATCAGTCTGTGGGTTTTCTAAACTCCCAAAAACGGTAAAGGC
AACCGATACGCGTTTTTTCAGTCGATTCACTGCCTCTGTGCAGGTGTGGAAAGGGTCTTCCAACTGACGT
CGCCAGGTCATCTGCCACCGTTCGCTCTCCCATGTTGTAGAATGCAAATCGCTACTTACCCGTGAAGGTG
TAGAATTGTCGCGAAGAGGAAACCTCCGTGACATCCGTAAGGAATTTCGCTGCGAGAACCCGCGCGCGCT
GTTCGCAGCCGACCGTCACGATCAGTGATGCCAAGTCTCCCTTCTTGACGCCCAGATGGTACGTGCGACC
ATCCGGGGTAAGGAAGATATTCTTTCCTTTGAGTTCCGACTGTCAGCGACAAACACACAACCACAGGACA
CGTCGTCATGCCCCCGTGCATAAGCTAGAAGTTTAGATAGCTAAATACCAGGTAAGCTCATGTTGAAAAC
AGGCTAGAGGCAGAAAAAAAAGCCGGAAAAAGATGTGATCTGCAACTGGTAAAGATGCCACTCTTGAACT
GGCAGGCACTACGCTCGTGTCCTGCACCACTGTATACGTCGTCATTGCTGCAAGAGAATCAACTACATAC
TAGGCAAATCTACGGCAAAACCCCTCGTCAAGAACTGTGAGGGAATGGGGCGGAAGCGCCCGCCCTTTTA
AATGCGACAAAGCCAGAAAGAGAAGCCCCGCTGCGTCAGACAAGAGGGGGAACGCAGGCGGACGCAGCCC
CCCGTGAATCAACGCAGAGCGTAGATGCGTGCCCTATCTTGCTGAAACTCACCATTGTACGCAAAAACAG
AGGCACTATATACACGACCTAAAGGATGGCGAAACGTTTCTTCACTTTTGTTTGGAAGACAAAAGGGAAT
GTTCAGGCAGCAGC
Protein Sequence 
>gi|237830025|ref|XP_002364310.1| uridine phosphorylase, putative [Toxoplasma gondii ME49]
MSELKGKNIFLTPDGRTYHLGVKKGDLASLIVTVGCEQRARVLAAKFLTDVTEVSSSRQFYTFTGKYIKG
GQRMSIVCIGMGAPMADFFIREASFVLEGEPLAVVRIGSCGIVDYATRPGTLMLSDESMYCYRNYCHFDG
EAALGNKRECGRDPRPYLLTAPVKADKRLTDLIEANLNAQGAAVKRGLNCSAETFFACQGRELPLWNDNN
ANLLKDMTDLGVVSLEMETHQIFHLMHQRQHSIPNGPKSYAASLMIGLVNRSNPNLTAHVTAEDQDKATL
AAGEAAFDALVTLVSEGIIKPAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A UP mutant, in combination with an OMPDC mutation, is attenuated in mice (Fox and Bzik, 2010).
References
Fox and Bzik, 2010: Fox BA, Bzik DJ. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infection and immunity. 2010; 78(9); 3744-3752. [PubMed: 20605980].