Victors

rop16
Victor ID	5218
Gene Name	rop16
NCBI Protein GI	296280509
Other Database IDs	CDD:259376 CDD:249558 CDD:263920 CDD:173623
Taxonomy ID	5811
Gene Strand (Orientation)	?
Protein Name	rhoptry protein 16
Protein Length	707
Protein Note	Family of FAM53; pfam15242
Protein Sequence	>gi\|296280509\|gb\|ADH04606.1\| rhoptry protein 16 [Toxoplasma gondii] MKVTTKGLAFALALLFCTRCATARDMSFEEAQKASEAAKRQIATLPSPDSTLSNPGSKHRNRGGSPAAGQ PSQSALQPEQAAAEVGLGAGGSTQGQGRTGGSAGAREERRSPSPQSAYPATSSASLRGYQTQLSPSHLPP RSSGPGGWFPTESIFTPWSSPPQPLTQRKPSLSGVVVTEFQEPQEQYGAASSLASSPKRYVSGASSSALS GKAVPTPASLGQENPLFPVQSATLDSGIQSPAQERRGSPQRQIAMSTENPADSGASQLASSVSSYVAVQT PHVKRSERIRRVRLSEEGLEEVQQLKAAAAQLLVAVPDYEAMRAVLQEAVLSEQRVATRKRKRKQPPGAV ESAVDEVFPPNERVMMINANGVPIALYNRGHLGSGHFGAVIKASLDDGTLYAAKVPYSQIVPNADATSAE LEAEISSARAELVKTIRQELDVRDKLVAKGLTLTETAEQYGLPLCQMTLTLPENKATVVRRGSRLVVVSK EVMLLPLIDGSALNSLVQSQPPFLFQRAVAREAIIALAKLHELGFAHGDVKLNNMMIDVHGFGHMLDMGS VRPVDSCVSEEDKYYLRLWAPELAKSQHTSQQTCLKRGALDVWALGLAIFEFVCFNRLPYSLSNLPSSLW SRVEHLSRLRLSDFSAKDCNESDPAVMGIVAQFLNPNPEERPELPKFVSSYTFFRQAPGVTSHLTRIPTT ELSSHRM
Molecule Role	Virulence factor
Molecule Role Annotation	Here we use genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16. Upon invasion by the parasite, this polymorphic protein is released from the apical organelles known as rhoptries and injected into the host cell, where it ultimately affects the activation of signal transducer and activator of transcription (STAT) signalling pathways and consequent downstream effects on a key host cytokine, interleukin (IL)-12.(Saeij et al., 2007)
References


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rop16