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ROP5

Victor ID 5207
Gene Name ROP5
Sequence Strain (Species/Organism) Toxoplasma gondii strain GT1
NCBI Protein GI 334848096
Genbank Accession BK008051
Other Database IDs CDD:258671
CDD:223589
CDD:173623
Taxonomy ID 5811
Gene Strand (Orientation) ?
Protein Name type I rhoptry protein 5
Protein Length 549
Protein Note Kinase-like; pfam14531
DNA Sequence 
>gi|334848095|tpg|BK008051.1| TPA_exp: Toxoplasma gondii strain GT1 type I rhoptry protein 5 (ROP5) gene, ROP5-major allele, complete cds
ATGGCGACGAAGCTCGCTAGACTAGCCACGTGGCTTGTCTTGGTAGGTTGCCTGTTGTGGCGGGCGGGGG
CAGTTCAGCTCTCTCCGCCAAACTCCAGGACGAATGATCTGGCTTCGGGAACCCCGCATGTGGCTCGTGG
GGACACTGAGGCGCAGTCAGGAACTGGAGACGATTCAGATTTTCCGCAGGCCGTGGCCGAAGAGGTGGCA
GATATGAGCGGCGGCAGAGTTCCCCGAGTGCCAGCATCGTCTACCACCACATCTGCGTCCGAGGGGATTT
TCAGAAGATTAGTTCGCAGACTTCGTCGGGGAAGAGGAACCGCAGATGGCGCAGGAGTTGCTGACGAAAC
CCATCAGGAGCCGCGCCCGCCACTTCGGAAGAGACTTGCTCAGCACTTCCGTAGGCTGAGGGGCTTCTTC
GGACGCCTTACGCCGAGGTGGCTCTCCGGTCTCGGCCGCCGGGCGCAAAGATGGTGGAGAGGGAGACAGA
GACCGCTGCTGGACCCTTCGTTTCATGGGTTGGAAGCTGGAGATTCGTTCATGCGCGACCTGCTGAAACG
TGAAGAAGAGCTGATTGGATACTGTCGCGAAGAAGCGTTGAAAGAACCTGCAGCGATGGTTGAGGCTGTC
ACGGCAACTGTATGGCCGCAAAATGCTGAAACAACCGTGGATTCGCTTTTGAGTCAGGGAGAGCGGAAGT
TGAAATTGGTGGAGCCTCTTCGAGTCGGTGACCGATCTGTCGTATTTTTAGTAAGGGATGTAGAGCGCCT
GGAGGATTTCGCTCTGAAGGTCTTCACTATGGGTGCCGAGAATTCCCGATCAGAGCTGGAGCGGTTGCAT
GAAGCGACTTTTGCGGCAGCGAGGTTGCTTGGGGAGAGTCCAGAGGAGGCACGGGACAGACGCAGGCTTT
TACTTCCCTCCGATGCTGTGGCAGTTCAGTCTCAGCCCCCTTTCGCTCAGCTGAGTCCAGGACAGAGCGA
CTATGCAGTCGCGAACTACTTGCTTCTCATGCCCGCTGCGTCGGTGGATCTTGAATTGCTCTTTAGGACA
TTGGATTTCCTGTATGTACTCAGGAGTACAGAAGATTTTTTAGCGCTTCACATACTAACGGCACAGCTGA
TCCGTCTGGCAGCCAACCTGCAGAGCAAAGGACTTGTGCATGGACATTTCACACCGGATAACCTTTTCAT
TATGCCCGATGGCCGCCTGATGCTGGGGGATGTATCCGTGTTGAGGAAGGTCGGAACCCGAGGACCGGCA
TCAAGCGTCCCGGTTACCTATGCGCCTCGCGAGTTCTTGAATGCAAGCACGGCAACATTTACACACGCGC
TGGATGCGTGGCAACTGGGTCTTAGCATATACCGGGTTTGGTGCCTATTCTTGCCTTTCGGACTCGTGAC
ACCTGGGATCAAAGGGTCATGGAAAAGACCAAGTCTACGAGTTCCAGGGACTGACAGTCTGGCATTCGGC
TCATGTACACCTCTGCCTGACTTCGTGCAGACACTTATTGGACGGTTCCTCAACTTCGATAGGCGTCGAC
GCCTGCTTCCCTTGGAGGCCATGGAGACGCCAGAGTTCCTCCAGCTCCAAAACGAAATATCGAGCAGCCT
ATCAACAGGACAACCCATTGCTGCGCCCTCAGTCGCTTGA
Protein Sequence 
>gi|334848096|tpg|DAA34828.1| TPA_exp: type I rhoptry protein 5 [Toxoplasma gondii]
MATKLARLATWLVLVGCLLWRAGAVQLSPPNSRTNDLASGTPHVARGDTEAQSGTGDDSDFPQAVAEEVA
DMSGGRVPRVPASSTTTSASEGIFRRLVRRLRRGRGTADGAGVADETHQEPRPPLRKRLAQHFRRLRGFF
GRLTPRWLSGLGRRAQRWWRGRQRPLLDPSFHGLEAGDSFMRDLLKREEELIGYCREEALKEPAAMVEAV
TATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLH
EATFAAARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQSDYAVANYLLLMPAASVDLELLFRT
LDFLYVLRSTEDFLALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSVLRKVGTRGPA
SSVPVTYAPREFLNASTATFTHALDAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDSLAFG
SCTPLPDFVQTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLSTGQPIAAPSVA
Molecule Role Virulence factor
Molecule Role Annotation a family of serine/threonine protein kinases found in rhoptries (ROPs) play an important role in mediating Toxoplasma gondii virulence. Deletion of ROP5 greatly reduces virulence. (Behnke et al., 2011)
References