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GRA25

Victor ID 5164
Gene Name GRA25
NCBI Protein GI 527311405
Taxonomy ID 508771
Gene Strand (Orientation) ?
Protein Name hypothetical protein
Protein Length 315
Protein Note encoded by transcript TGME49_290700; Signal peptide predicted by SignalP 2.0 HMM (probability 0.999) with cleavage site probability 0.504 at residue 21
Protein Sequence 
>gi|527311405|gb|EPT28036.1| hypothetical protein TGME49_290700 [Toxoplasma gondii ME49]
MKRFWLCALLSLLEFSWGCNSLGPSLPSFQVAEGAFFGRLRNWFGKNAEQKPEVPVAPVADDDAGSEEES
SSHYGVKTLTASTTTTTTTTTTTTVTSTKPEGVWEEEYDSMEVPYTPLPPLRGIGLLGGAIFVSLAFNLG
KLPLLMGGIGVVQYINSVVQRMHARRAADAALRRFEDRRELVRARRRRRWIQTFYSHNALQQDRATRKGE
TQNEESNATLANSSTGKGDGGTAGSEAPPRGIHADAASERTWNTGGKKGSLHDSGLHAEGSDKRTNPSET
REVPKTRLRKPTERNTKAQVKKKTPRENLPEFDRN
Molecule Role Virulence factor
Molecule Role Annotation In vitro experiments with a type II Ãˇâ€¯gra25 strain showed that macrophages infected with this strain secrete lower levels of CCL2 and CXCL1 than those infected with the wild-type or complemented control parasites. In vivo experiments showed that mice infected with a type II Ãˇâ€¯gra25 strain are able to survive an otherwise lethal dose of Toxoplasma tachyzoites and that complementation of the mutant with an ectopic copy of GRA25 largely rescues this phenotype.(Shastri et al., 2014)
References